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Grm5 glutamate metabotropic receptor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24418, updated on 6-Sep-2021

Summary

Official Symbol
Grm5provided by RGD
Official Full Name
glutamate metabotropic receptor 5provided by RGD
Primary source
RGD:2746
See related
Ensembl:ENSRNOG00000016429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
mGluR5; mGlur5
Summary
may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 246.3) See more
Orthologs
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Genomic context

See Grm5 in Genome Data Viewer
Location:
1q32
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (141310069..141884980)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (151207846..151785038)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene U7 small nuclear RNA Neighboring gene tyrosinase Neighboring gene splicing factor 3A subunit 1-like Neighboring gene eukaryotic translation initiation factor 5-like Neighboring gene uncharacterized LOC102554680 Neighboring gene cathepsin C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables A2A adenosine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding TAS
Traceable Author Statement
more info
PubMed 
enables PLC activating G protein-coupled glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding TAS
Traceable Author Statement
more info
PubMed 
enables glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling using intracellular calcium source IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in learning IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within learning ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of age-related behavioral decline IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of age-related behavioral decline ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of locomotion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of long-term neuronal synaptic plasticity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of intracellular calcium activated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular calcium activated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
metabotropic glutamate receptor 5
Names
glutamate receptor, metabotropic 5
metabotropic glutamate receptor (mGluR5)
metabotropic glutamate receptor 5b

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017012.2NP_058708.1  metabotropic glutamate receptor 5 precursor

    See identical proteins and their annotated locations for NP_058708.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000041
    UniProtKB/Swiss-Prot
    P31424
    Related
    ENSRNOP00000040016.2, ENSRNOT00000050639.2
    Conserved Domains (5) summary
    cd06374
    Location:26496
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:590823
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67471
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:507556
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11211171
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    141310069..141884980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096032.1XP_038951960.1  metabotropic glutamate receptor 5 isoform X1

    Conserved Domains (5) summary
    pfam05109
    Location:10131171
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. XM_017588778.2XP_017444267.1  metabotropic glutamate receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    P31424
    UniProtKB/TrEMBL
    B2CZC8
    Conserved Domains (5) summary
    pfam05109
    Location:10131171
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  3. XM_006229659.4XP_006229721.1  metabotropic glutamate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006229721.1

    UniProtKB/Swiss-Prot
    P31424
    UniProtKB/TrEMBL
    B2CZC8
    Related
    ENSRNOP00000022059.4
    Conserved Domains (5) summary
    pfam05109
    Location:10131171
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  4. XM_017588781.2XP_017444270.1  metabotropic glutamate receptor 5 isoform X2

    UniProtKB/Swiss-Prot
    P31424
  5. XM_017588779.2XP_017444268.1  metabotropic glutamate receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    P31424
    UniProtKB/TrEMBL
    B2CZC8
    Conserved Domains (5) summary
    pfam05109
    Location:10131171
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  6. XM_017588780.2XP_017444269.1  metabotropic glutamate receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    P31424
    UniProtKB/TrEMBL
    B2CZC8
    Conserved Domains (5) summary
    pfam05109
    Location:10131171
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
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