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Grm1 glutamate metabotropic receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24414, updated on 18-Sep-2024

Summary

Official Symbol
Grm1provided by RGD
Official Full Name
glutamate metabotropic receptor 1provided by RGD
Primary source
RGD:2742
See related
EnsemblRapid:ENSRNOG00000014290 AllianceGenome:RGD:2742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gprc1a
Summary
Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and estrogen receptor binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; calcium-mediated signaling; and regulation of glutamatergic synaptic transmission. Located in axon; dendritic spine; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 90.5) See more
Orthologs
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Genomic context

See Grm1 in Genome Data Viewer
Location:
1p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (6878542..7273447, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (5058285..5453170, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (4753141..5165859, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAB32, member RAS oncogene family Neighboring gene small nucleolar RNA SNORA17 Neighboring gene dynactin 3-like 1 Neighboring gene SNF2 histone linker PHD RING helicase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
enables PLC activating G protein-coupled glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization TAS
Traceable Author Statement
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glutamate secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synaptic transmission, glutamatergic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, GABAergic TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of G protein-coupled receptor dimeric complex ISO
Inferred from Sequence Orthology
more info
 
part_of G protein-coupled receptor homodimeric complex IEA
Inferred from Electronic Annotation
more info
 
part_of G protein-coupled receptor homodimeric complex ISO
Inferred from Sequence Orthology
more info
 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metabotropic glutamate receptor 1
Names
G protein coupled receptor family C group 1 member A
glutamate receptor, metabotropic 1
mGluR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114330.2NP_001107802.1  metabotropic glutamate receptor 1 isoform beta precursor

    Status: VALIDATED

    Description
    Transcript Variant: his variant (2) encodes the shorter isoform (beta). Isoform beta has a different subcellular distribution than isoform alpha and may be functionally distinct due to differential G-protein coupling of its novel C-terminal sequence.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P23385
    UniProtKB/TrEMBL
    Q9WTJ1
    Related
    ENSRNOP00000047790.3, ENSRNOT00000044325.5
    Conserved Domains (4) summary
    cd06374
    Location:36510
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:604837
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:77485
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:521570
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. NM_017011.2NP_058707.2  metabotropic glutamate receptor 1 isoform alpha precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (alpha).
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P23385
    UniProtKB/TrEMBL
    A6JP39, G3V7U1
    Related
    ENSRNOP00000019319.1, ENSRNOT00000019319.5
    Conserved Domains (4) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11501199
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    6878542..7273447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588777.3XP_017444266.1  metabotropic glutamate receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P23385
    UniProtKB/TrEMBL
    A6JP39, G3V7U1
    Conserved Domains (4) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11501199
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. XM_063280712.1XP_063136782.1  metabotropic glutamate receptor 1 isoform X2