Grin2c glutamate ionotropic receptor NMDA type subunit 2C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grin2cprovided by RGD
Official Full Name: glutamate ionotropic receptor NMDA type subunit 2Cprovided by RGD
Primary source: RGD:2739
See related: Ensembl:ENSRNOG00000003280 AllianceGenome:RGD:2739
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NR2C; GluN2C; NMDAR2C
Summary: Enables PDZ domain binding activity; glutamate binding activity; and monoatomic ion channel activity. Involved in ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and regulation of monoatomic cation transmembrane transport. Located in postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Orthologous to human GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 107.2), Lung (RPKM 14.0) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 10q32.1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (100987410..101006064, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (100488430..100507083, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBP791 ((2S*,3R*)-1-(7-(2-carboxyethyl)phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selectivity over GluN2A-containing receptors, and that a methionine and a lysine residue in the ligand binding pocket are the critical molecular elements for the subtype-specific binding.
Title: Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors.
a neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to promote neuronal survival following ischemia.
Title: Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia.
these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface
Title: Identification of Novel 14-3-3 Residues That Are Critical for Isoform-specific Interaction with GluN2C to Regulate N-Methyl-D-aspartate (NMDA) Receptor Trafficking.
These results support a critical role for GluN2C receptors in the amygdala in the consolidation of learned fear responses.
Title: Potentiation of GluN2C/D NMDA receptor subtypes in the amygdala facilitates the retention of fear and extinction learning in mice.
Data indicate that tetrahydroisoquinolines showed subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits.
Title: Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.
NR2C expression has an initial rise from postnatal day P2 to P3, but remains relatively constant thereafter until P21, except for a significant fall at P12 in the pre-Botzinger complex.
Title: Postnatal development of N-methyl-D-aspartate receptor subunits 2A, 2B, 2C, 2D, and 3B immunoreactivity in brain stem respiratory nuclei of the rat.
PKB/Akt directly phosphorylates NR2C on serine 1096
Title: Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C.
Hindbrain injection of competitive NMDA antagonists with selectivity or preference for the NMDA receptor NR2B or NR2C subunits increases food intake.
Title: Blockade of hindbrain NMDA receptors containing NR2 subunits increases sucrose intake.
NMDA2C and NMDA2D subunits are in the rat striatum
Title: Cholinergic neurons of the adult rat striatum are immunoreactive for glutamatergic N-methyl-d-aspartate 2D but not N-methyl-d-aspartate 2C receptor subunits.
the basal levels of activated NF-kappaB in cortical neurons are maintained partially by synaptic activity involving N-methyl- D-aspartate (NMDA) and AMPA/kainate glutamate receptors
Title: Involvement of NMDA receptors and a p21Ras-like guanosine triphosphatase in the constitutive activation of nuclear factor-kappa-B in cortical neurons.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94563 (e-PCR)
- UniSTS:119811

RH132419 (e-PCR)
- UniSTS:215702

Grin2c (e-PCR), detects polymorphism
- UniSTS:143263

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NMDA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables NMDA glutamate receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate binding	IEA Inferred from Electronic Annotation more info
enables glutamate-gated receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within directional locomotion	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	NAS Non-traceable Author Statement more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of NMDA selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	EXP Inferred from Experiment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 2C

Names: N-methyl D-aspartate receptor subtype 2C; NMDA glutamate receptor; glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001439449.1 → NP_001426378.1 glutamate receptor ionotropic, NMDA 2C precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q00961

UniProtKB/TrEMBL

Q62644
NM_012575.4 → NP_036707.4 glutamate receptor ionotropic, NMDA 2C precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q00961

UniProtKB/TrEMBL

Q62644

Related

ENSRNOP00000004477.3, ENSRNOT00000004477.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

100987410..101006064 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268392.1 → XP_063124462.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644
XM_039085182.2 → XP_038941110.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644

Conserved Domains (3) summary

cd13718
Location:413 → 813

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 397

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:850 → 925

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_039085184.2 → XP_038941112.1 glutamate receptor ionotropic, NMDA 2C isoform X2

UniProtKB/Swiss-Prot

Q00961

UniProtKB/TrEMBL

Q62644

Conserved Domains (3) summary

cd13718
Location:400 → 800

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:837 → 912

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_017596990.3 → XP_017452479.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644

Conserved Domains (3) summary

cd13718
Location:413 → 813

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 397

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:850 → 925

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_063268394.1 → XP_063124464.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644
XM_063268395.1 → XP_063124465.1 glutamate receptor ionotropic, NMDA 2C isoform X2

UniProtKB/Swiss-Prot

Q00961

UniProtKB/TrEMBL

Q62644
XM_017596989.3 → XP_017452478.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644

Conserved Domains (3) summary

cd13718
Location:413 → 813

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 397

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:850 → 925

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_063268393.1 → XP_063124463.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644
XM_063268390.1 → XP_063124460.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644
XM_006247709.5 → XP_006247771.1 glutamate receptor ionotropic, NMDA 2C isoform X2

See identical proteins and their annotated locations for XP_006247771.1

UniProtKB/Swiss-Prot

Q00961

UniProtKB/TrEMBL

Q62644

Conserved Domains (3) summary

cd13718
Location:400 → 800

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:837 → 912

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_039085181.2 → XP_038941109.1

Conserved Domains (3) summary

cd13718
Location:413 → 813

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 397

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:850 → 925

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_017596992.3 → XP_017452481.1 glutamate receptor ionotropic, NMDA 2C isoform X2

UniProtKB/Swiss-Prot

Q00961

UniProtKB/TrEMBL

Q62644

Conserved Domains (3) summary

cd13718
Location:400 → 800

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:837 → 912

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_017596988.3 → XP_017452477.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644

Conserved Domains (3) summary

cd13718
Location:413 → 813

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:41 → 397

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:850 → 925

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_063268391.1 → XP_063124461.1 glutamate receptor ionotropic, NMDA 2C isoform X1

UniProtKB/TrEMBL

A0A0G2JSH8, Q62644
XM_063268396.1 → XP_063124466.1 glutamate receptor ionotropic, NMDA 2C isoform X2

UniProtKB/Swiss-Prot

Q00961

UniProtKB/TrEMBL

Q62644
XM_063268397.1 → XP_063124467.1 glutamate receptor ionotropic, NMDA 2C isoform X3