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Grin1 glutamate ionotropic receptor NMDA type subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24408, updated on 5-Jan-2023

Summary

Official Symbol
Grin1provided by RGD
Official Full Name
glutamate ionotropic receptor NMDA type subunit 1provided by RGD
Primary source
RGD:2736
See related
Ensembl:ENSRNOG00000011726 AllianceGenome:RGD:2736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NR1; GluN1; NMDAR1
Summary
Enables several functions, including amino acid binding activity; amyloid-beta binding activity; and ligand-gated ion channel activity. Involved in several processes, including positive regulation of dendritic spine maintenance; protein heterotetramerization; and response to fungicide. Located in several cellular components, including dendrite; postsynaptic density; and synaptic cleft. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Biomarker of cognitive disorder; middle cerebral artery infarction; placental insufficiency; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 191.9) See more
Orthologs
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Genomic context

See Grin1 in Genome Data Viewer
Location:
3p13
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8103680..8130603, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2507745..2534664, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 2 Neighboring gene transmembrane protein 210 Neighboring gene leucine rich repeat containing 26 Neighboring gene mannosidase, alpha, class 1B, member 1 Neighboring gene dipeptidylpeptidase 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to NMDA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NMDA glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NMDA glutamate receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables NMDA glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to NMDA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables NMDA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables NMDA glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables glutamate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables glutamate-gated calcium ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glycine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glycine binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ionotropic glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within associative learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transmembrane import into cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within conditioned taste aversion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in ionotropic glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ionotropic glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within long-term memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male mating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within memory ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic cation transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within olfactory learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pons maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Schwann cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prepulse inhibition ISO
Inferred from Sequence Orthology
more info
 
involved_in propylene metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein heterotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein localization to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell communication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of monoatomic cation transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal synaptic plasticity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of respiratory gaseous exchange ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amine IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to amphetamine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to fungicide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glycine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to morphine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in rhythmic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within social behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within startle response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within suckling behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NMDA selective glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NMDA selective glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of NMDA selective glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of NMDA selective glutamate receptor complex TAS
Traceable Author Statement
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic branch IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane IPI
Inferred from Physical Interaction
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 1
Names
N-methyl-D-aspartate glutamate receptor
N-methyl-D-aspartate receptor subunit NR1
NMD-R1
NMDA R1 receptor C1 cassette
glutamate [NMDA] receptor subunit zeta-1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
neurotransmitter receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270602.1NP_001257531.1  glutamate receptor ionotropic, NMDA 1 isoform 1b precursor

    See identical proteins and their annotated locations for NP_001257531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1b).
    Source sequence(s)
    FM039130, JACYVU010000115, U08263
    UniProtKB/Swiss-Prot
    P35439
    Related
    ENSRNOP00000029227.5, ENSRNOT00000037725.6
    Conserved Domains (3) summary
    cd13719
    Location:416820
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06379
    Location:25404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    pfam10562
    Location:856884
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
  2. NM_001270603.1NP_001257532.1  glutamate receptor ionotropic, NMDA 1 isoform 2b precursor

    See identical proteins and their annotated locations for NP_001257532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2b) has the same N- and C-termini but is shorter compared to isoform 1b.
    Source sequence(s)
    FM039130, JACYVU010000115, U08264
    UniProtKB/Swiss-Prot
    P35439
    Related
    ENSRNOP00000043301.3, ENSRNOT00000044246.5
    Conserved Domains (3) summary
    cd13719
    Location:416820
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06379
    Location:25404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    pfam10562
    Location:856884
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
  3. NM_001270605.1NP_001257534.1  glutamate receptor ionotropic, NMDA 1 isoform 2a precursor

    See identical proteins and their annotated locations for NP_001257534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2a) has the same N- and C-termini but is shorter compared to isoform 1b.
    Source sequence(s)
    FM039130, JACYVU010000115, U08262
    UniProtKB/Swiss-Prot
    P35439
    Conserved Domains (3) summary
    cd13719
    Location:395799
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06379
    Location:25383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    pfam10562
    Location:835863
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
  4. NM_001270606.1NP_001257535.1  glutamate receptor ionotropic, NMDA 1 isoform 3b precursor

    See identical proteins and their annotated locations for NP_001257535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3b) has a shorter and distinct C-terminus compared to variant 1b.
    Source sequence(s)
    FM039130, JACYVU010000115, U08266
    UniProtKB/TrEMBL
    Q62648
    Conserved Domains (3) summary
    cd13719
    Location:416820
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06379
    Location:25404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    pfam10562
    Location:856884
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
  5. NM_001270608.1NP_001257537.1  glutamate receptor ionotropic, NMDA 1 isoform 4b precursor

    See identical proteins and their annotated locations for NP_001257537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (4b) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1b.
    Source sequence(s)
    FM039130, JACYVU010000115, U08268
    UniProtKB/Swiss-Prot
    P35439
    Conserved Domains (3) summary
    cd13719
    Location:416820
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06379
    Location:25404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    pfam10562
    Location:856884
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
  6. NM_001270610.1NP_001257539.1  glutamate receptor ionotropic, NMDA 1 isoform 4a precursor

    See identical proteins and their annotated locations for NP_001257539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate in-frame exons and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (4a) lacks two alternate internal segments and has a shorter and distinct C-terminus compared to isoform 1b.
    Source sequence(s)
    FM039130, JACYVU010000115, U08267
    UniProtKB/Swiss-Prot
    P35439
    Conserved Domains (3) summary
    cd13719
    Location:395799
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06379
    Location:25383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    pfam10562
    Location:835863
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
  7. NM_001287423.1NP_001274352.1  glutamate receptor ionotropic, NMDA 1 isoform 3a precursor

    See identical proteins and their annotated locations for NP_001274352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3a) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1b.
    Source sequence(s)
    FM039130, JACYVU010000115, U08265
    UniProtKB/Swiss-Prot
    P35439
    Conserved Domains (3) summary
    cd13719
    Location:395799
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06379
    Location:25383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    pfam10562
    Location:835863
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
  8. NM_017010.2NP_058706.1  glutamate receptor ionotropic, NMDA 1 isoform 1a precursor

    See identical proteins and their annotated locations for NP_058706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (1a) has the same N- and C-termini but is shorter compared to isoform 1b.
    Source sequence(s)
    FM039130, JACYVU010000115, U08261
    UniProtKB/Swiss-Prot
    P35439, Q62646
    Related
    ENSRNOP00000049198.1, ENSRNOT00000049297.4
    Conserved Domains (3) summary
    cd13719
    Location:395799
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06379
    Location:25383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    pfam10562
    Location:835863
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    8103680..8130603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)