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Gpx1 glutathione peroxidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24404, updated on 21-Jul-2018

Summary

Official Symbol
Gpx1provided by RGD
Official Full Name
glutathione peroxidase 1provided by RGD
Primary source
RGD:2729
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GSHPx; GSHPx-1
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016]
Expression
Biased expression in Liver (RPKM 6858.1), Heart (RPKM 3806.1) and 7 other tissues See more
Orthologs

Genomic context

See Gpx1 in Genome Data Viewer
Location:
8q32
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117117430..117118528)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (116466118..116467216)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm3 pseudogene Neighboring gene T-cell leukemia translocation altered Neighboring gene ras homolog family member A Neighboring gene ubiquitin specific peptidase 4 Neighboring gene hypothetical LOC498675 Neighboring gene coiled-coil domain containing 36 Neighboring gene hypothetical protein LOC680045

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
UV protection IEA
Inferred from Electronic Annotation
more info
 
UV protection ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiogenesis involved in wound healing IEA
Inferred from Electronic Annotation
more info
 
angiogenesis involved in wound healing ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell development IEA
Inferred from Electronic Annotation
more info
 
endothelial cell development ISO
Inferred from Sequence Orthology
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
heart contraction IEA
Inferred from Electronic Annotation
more info
 
heart contraction ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
interaction with symbiont IEA
Inferred from Electronic Annotation
more info
 
interaction with symbiont ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein oxidation IEA
Inferred from Electronic Annotation
more info
 
protein oxidation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression, epigenetic IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
regulation of mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to folic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
 
response to hydroperoxide ISO
Inferred from Sequence Orthology
more info
 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
response to selenium ion IEA
Inferred from Electronic Annotation
more info
 
response to selenium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to selenium ion ISO
Inferred from Sequence Orthology
more info
 
response to symbiotic bacterium IEA
Inferred from Electronic Annotation
more info
 
response to symbiotic bacterium ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
 
temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
temperature homeostasis ISO
Inferred from Sequence Orthology
more info
 
triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
vasodilation IEA
Inferred from Electronic Annotation
more info
 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Lewy body IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with Lewy body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutathione peroxidase 1
Names
GPx-1
cellular glutathione peroxidase
NP_110453.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030826.4NP_110453.3  glutathione peroxidase 1

    See identical proteins and their annotated locations for NP_110453.3

    Status: REVIEWED

    Source sequence(s)
    FQ139913, FQ231953
    UniProtKB/Swiss-Prot
    P04041
    Conserved Domains (1) summary
    cd00340
    Location:13190
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    117117430..117118528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    108329847..108330945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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