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Shank1 SH3 and multiple ankyrin repeat domains 1 [ Mus musculus (house mouse) ]

Gene ID: 243961, updated on 4-Jun-2024

Summary

Official Symbol
Shank1provided by MGI
Official Full Name
SH3 and multiple ankyrin repeat domains 1provided by MGI
Primary source
MGI:MGI:3613677
See related
Ensembl:ENSMUSG00000038738 AllianceGenome:MGI:3613677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and regulation of signal transduction. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 16.9), cortex adult (RPKM 13.3) and 9 other tissues See more
Orthologs
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Genomic context

See Shank1 in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43958343..44009518)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44308916..44360094)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7238 Neighboring gene STARR-positive B cell enhancer ABC_E129 Neighboring gene C-type lectin domain family 11, member a Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene STARR-seq mESC enhancer starr_18792 Neighboring gene predicted gene, 39001 Neighboring gene synaptotagmin III

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables ankyrin repeat binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables somatostatin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of postsynaptic density IEP
Inferred from Expression Pattern
more info
PubMed 
enables structural constituent of postsynaptic density IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables synaptic receptor adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables synaptic receptor adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables synaptic receptor adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adult behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of affect ISO
Inferred from Sequence Orthology
more info
 
involved_in habituation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in olfactory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in righting reflex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in vocalization behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SH3 and multiple ankyrin repeat domains protein 1
Names
SH3/ankyrin domain gene 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034115.1NP_001029287.1  SH3 and multiple ankyrin repeat domains protein 1

    See identical proteins and their annotated locations for NP_001029287.1

    Status: VALIDATED

    Source sequence(s)
    AC152939
    Consensus CDS
    CCDS52229.1
    UniProtKB/Swiss-Prot
    D3YZU1
    Related
    ENSMUSP00000103571.2, ENSMUST00000107938.8
    Conserved Domains (8) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd09506
    Location:21002165
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9471156
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43958343..44009518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540864.5XP_006540927.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006540927.1

    UniProtKB/Swiss-Prot
    D3YZU1
    Conserved Domains (8) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd09506
    Location:21002165
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9471156
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  2. XM_006540868.5XP_006540931.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X8

    Conserved Domains (7) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9471156
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  3. XM_006540867.5XP_006540930.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X7

    Conserved Domains (7) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9471156
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  4. XM_036153110.1XP_036009003.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X5

    Conserved Domains (8) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd09506
    Location:20652130
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9121121
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  5. XM_006540865.5XP_006540928.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X2

    UniProtKB/TrEMBL
    D3YZU4
    Related
    ENSMUSP00000103568.2, ENSMUST00000107935.8
    Conserved Domains (8) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd09506
    Location:20922157
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9391148
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  6. XM_006540866.5XP_006540929.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X3

    UniProtKB/TrEMBL
    D3YZU5
    Related
    ENSMUSP00000103567.2, ENSMUST00000107934.2
    Conserved Domains (8) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd09506
    Location:20912156
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9381147
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:652745
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  7. XM_030242576.2XP_030098436.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X4

    Conserved Domains (8) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd09506
    Location:20832148
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9301139
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:652745
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  8. XM_036153111.1XP_036009004.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X6

    Conserved Domains (8) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd09506
    Location:20562121
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9031112
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:652745
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  9. XM_030242575.2XP_030098435.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3YZU1
    Conserved Domains (8) summary
    PTZ00322
    Location:333468
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd09506
    Location:21002165
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PHA03095
    Location:174392
    PHA03095; ankyrin-like protein; Provisional
    PRK07764
    Location:9471156
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:279311
    ANK; ANK repeat [structural motif]
    cd17175
    Location:70158
    FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  10. XM_006540874.3XP_006540937.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X15

    Conserved Domains (3) summary
    cd09506
    Location:14501515
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:297506
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:51104
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. XM_006540872.3XP_006540935.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X13

    Conserved Domains (3) summary
    cd09506
    Location:14861551
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:333542
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:47140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  12. XM_030242578.2XP_030098438.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X14

    Conserved Domains (3) summary
    cd09506
    Location:14781543
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:325534
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:47140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  13. XM_006540869.4XP_006540932.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X9

    Conserved Domains (3) summary
    cd09506
    Location:15781643
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:425634
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:179232
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  14. XM_036153113.1XP_036009006.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X12

    Conserved Domains (3) summary
    cd09506
    Location:15291594
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:376585
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:130183
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  15. XM_036153112.1XP_036009005.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X9

    Conserved Domains (3) summary
    cd09506
    Location:15781643
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:425634
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:179232
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  16. XM_006540870.4XP_006540933.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X10

    Conserved Domains (3) summary
    cd09506
    Location:15621627
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:409618
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:150216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  17. XM_006540871.4XP_006540934.3  SH3 and multiple ankyrin repeat domains protein 1 isoform X11

    Conserved Domains (3) summary
    cd09506
    Location:15521617
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:399608
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00992
    Location:113206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  18. XM_006540876.5XP_006540939.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X17

    Conserved Domains (2) summary
    cd09506
    Location:12081273
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:55264
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
  19. XM_006540875.5XP_006540938.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X16

    Conserved Domains (2) summary
    cd09506
    Location:12431308
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    PRK07764
    Location:90299
    PRK07764; DNA polymerase III subunits gamma and tau; Validated