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Kirrel2 kirre like nephrin family adhesion molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 243911, updated on 5-Mar-2024

Summary

Official Symbol
Kirrel2provided by MGI
Official Full Name
kirre like nephrin family adhesion molecule 2provided by MGI
Primary source
MGI:MGI:2442334
See related
Ensembl:ENSMUSG00000036915 AllianceGenome:MGI:2442334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NLG1; NEPH3; C330019F22Rik
Summary
Enables identical protein binding activity. Acts upstream of or within cell-cell adhesion and negative regulation of protein phosphorylation. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including central nervous system; genitourinary system; nasal epithelium; pancreas; and retina. Orthologous to human KIRREL2 (kirre like nephrin family adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 1.4), CNS E11.5 (RPKM 1.2) and 6 other tissues See more
Orthologs
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Genomic context

See Kirrel2 in Genome Data Viewer
Location:
7 B1; 7 18.36 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30146955..30160105, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30447766..30457515, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18519 Neighboring gene predicted gene, 30646 Neighboring gene amyloid beta precursor like protein 1 Neighboring gene predicted gene, 45979 Neighboring gene nephrosis 1, nephrin Neighboring gene nephrosis 1 homolog, nephrin, opposite strand Neighboring gene ribosomal protein S12, pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in slit diaphragm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kin of IRRE-like protein 2
Names
X kin of IRRE like 2
kin of IRRE like 2
kin of irregular chiasm-like 2
kin of irregular chiasm-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172898.3NP_766486.1  kin of IRRE-like protein 2 precursor

    See identical proteins and their annotated locations for NP_766486.1

    Status: PROVISIONAL

    Source sequence(s)
    AC149067
    Consensus CDS
    CCDS39883.1
    UniProtKB/Swiss-Prot
    Q7TQ98, Q7TSU7
    UniProtKB/TrEMBL
    A0A4X8, B2RXY2
    Related
    ENSMUSP00000039395.8, ENSMUST00000045817.14
    Conserved Domains (4) summary
    smart00409
    Location:27116
    IG; Immunoglobulin
    pfam13927
    Location:223292
    Ig_3; Immunoglobulin domain
    cd00096
    Location:395399
    Ig; Ig strand A [structural motif]
    cl11960
    Location:394498
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30146955..30160105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153095.1XP_036008988.1  kin of IRRE-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7TQ98, Q7TSU7
    UniProtKB/TrEMBL
    A0A4X8, B2RXY2
    Conserved Domains (4) summary
    smart00409
    Location:27116
    IG; Immunoglobulin
    pfam13927
    Location:223292
    Ig_3; Immunoglobulin domain
    cd00096
    Location:395399
    Ig; Ig strand A [structural motif]
    cl11960
    Location:394498
    Ig; Immunoglobulin domain