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Gh1 growth hormone 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24391, updated on 9-Dec-2024

Summary

Official Symbol
Gh1provided by RGD
Official Full Name
growth hormone 1provided by RGD
Primary source
RGD:2686
See related
EnsemblRapid:ENSRNOG00000011207 AllianceGenome:RGD:2686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gh; Ghb1; RNGHGP
Summary
Enables hormone activity. Involved in several processes, including cellular response to alkaline pH; cellular response to thyroid hormone stimulus; and positive regulation of steroid hormone biosynthetic process. Located in collagen-containing extracellular matrix; extracellular space; and secretory granule. Used to study isolated growth hormone deficiency and type 1 diabetes mellitus. Biomarker of congenital hypothyroidism; osteoporosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Gh1 in Genome Data Viewer
Location:
10q32.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91727883..91729860, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91228102..91230079, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94486204..94488181, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D2 Neighboring gene testicular cell adhesion molecule 1 Neighboring gene CD79b molecule Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC108352146

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables growth hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables prolactin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in bone maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to alkaline pH IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to thyroid hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in growth hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in growth hormone receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of D-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid hormone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to food ISO
Inferred from Sequence Orthology
more info
 
involved_in response to light stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of growth hormone receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
somatotropin
Names
growth hormone b1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034848.2NP_001030020.2  somatotropin precursor

    See identical proteins and their annotated locations for NP_001030020.2

    Status: VALIDATED

    Source sequence(s)
    BC166872, BI278832, CB316202
    UniProtKB/Swiss-Prot
    P01244
    UniProtKB/TrEMBL
    A0A0M6L0P3, A6HK30, B2RYR2
    Related
    ENSRNOP00000015818.4, ENSRNOT00000015818.7
    Conserved Domains (1) summary
    cd10285
    Location:35214
    somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    91727883..91729860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)