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Zfp14 zinc finger protein 14 [ Mus musculus (house mouse) ]

Gene ID: 243906, updated on 11-Jun-2025
Official Symbol
Zfp14provided by MGI
Official Full Name
zinc finger protein 14provided by MGI
Primary source
MGI:MGI:99160
See related
Ensembl:ENSMUSG00000053985 AllianceGenome:MGI:99160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Krox-9; Zfp-14; mKIAA1559; 4732429I09Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within blastocyst hatching. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cranial ganglion; dorsal root ganglion; genitourinary system; and hemolymphoid system gland. Orthologous to human ZFP14 (ZFP14 zinc finger protein). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in bladder adult (RPKM 3.1), CNS E18 (RPKM 2.8) and 26 other tissues See more
Orthologs
human all
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See Zfp14 in Genome Data Viewer
Location:
7 B1; 7 17.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29735782..29751664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30036357..30051396, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31735 Neighboring gene STARR-seq mESC enhancer starr_18498 Neighboring gene zinc finger protein 568 Neighboring gene STARR-seq mESC enhancer starr_18501 Neighboring gene STARR-positive B cell enhancer ABC_E8161 Neighboring gene zinc finger protein 82 Neighboring gene STARR-seq mESC enhancer starr_18504 Neighboring gene zinc finger protein 566 Neighboring gene STARR-positive B cell enhancer ABC_E869

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster. Mohibi S, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jan 1. PMID 36349645, Free PMC Article
  2. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
  3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster.
    Title: Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Homology

Clone Names

  • KIAA1559

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 14
Names
zinc finger protein Krox-9

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358860.1 → NP_001345789.1  zinc finger protein 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple segments in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC149283
    Consensus CDS
    CCDS39875.1
    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Related
    ENSMUSP00000076960.8, ENSMUST00000077787.8
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  2. NM_011748.2 → NP_035878.1  zinc finger protein 14

    See identical proteins and their annotated locations for NP_035878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK030632, AK032214, AK045631, BY128777
    Consensus CDS
    CCDS39875.1
    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  3. NM_178733.5 → NP_848848.1  zinc finger protein 14

    See identical proteins and their annotated locations for NP_848848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK030632, AK032214, BY128777
    Consensus CDS
    CCDS39875.1
    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Related
    ENSMUSP00000146824.2, ENSMUST00000207873.2
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29735782..29751664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153086.1 → XP_036008979.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036153092.1 → XP_036008985.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036153085.1 → XP_036008978.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  4. XM_036153093.1 → XP_036008986.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Related
    ENSMUSP00000146913.2, ENSMUST00000207072.2
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  5. XM_030242567.2 → XP_030098427.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  6. XM_036153088.1 → XP_036008981.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  7. XM_036153090.1 → XP_036008983.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  8. XM_036153094.1 → XP_036008987.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  9. XM_036153089.1 → XP_036008982.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain

  10. XM_036153091.1 → XP_036008984.1  zinc finger protein 14 isoform X1

    UniProtKB/Swiss-Prot
    P10755, Q5DTW6, Q8BFZ5
    Conserved Domains (4) summary
    COG5048
    Location:222 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198 → 218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:182 → 206
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10755.2 GenPept UniProtKB/Swiss-Prot:P10755

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