Gfap glial fibrillary acidic protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gfapprovided by RGD
Official Full Name: glial fibrillary acidic proteinprovided by RGD
Primary source: RGD:2679
See related: Ensembl:ENSRNOG00000002919
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables integrin binding activity and kinase binding activity. A structural constituent of cytoskeleton. Involved in positive regulation of glial cell proliferation; regulation of chaperone-mediated autophagy; and response to wounding. Located in astrocyte projection and cytoplasmic side of lysosomal membrane. Biomarker of brain edema and retinal disease. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein). [provided by Alliance of Genome Resources, Nov 2021]
Expression: Restricted expression toward (RPKM 849.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87852891..87861631, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90990762..90999435, complement)

Chromosome 10 - NC_051345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats.
Title: Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats.
Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain.
Title: Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain.
Reduced astrocytic expression of GFAP in the offspring of female rats that received hypercaloric diet.
Title: Reduced astrocytic expression of GFAP in the offspring of female rats that received hypercaloric diet.
Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity.
Title: Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity.
Results show that clustered regularly interspaced short palindromic repeats/Cas9-mediated SOX9 knockout not only inhibitedglial fibrillary acidic protein expression in rat Muller cells but also attenuated cell migration ability. These results suggest that inhibition of SOX9 activity may be a novel therapeutic strategy for reduction of glial cell activity.
Title: CRISPR-mediated SOX9 knockout inhibits GFAP expression in retinal glial (Müller) cells.
demonstrate increased DNA methylation coupled with decreased histone acetylation at the Gfap promoter leading to suppression of Gfap expression under maternal hypothyroidism
Title: Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism.
The present study found that social isolation during adolescence resulted in abnormal locomotor, emotional and cognitive behaviors and increased the expression of GFAP, ANXA2 and VIM in PFC of adult rats
Title: Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats.
GFAP-positive structures were present and exhibited a tendency to become linear on both sides, with an increased density on the left. NFAP-positive expression was present in the left treated limb with a disorganized pattern
Title: Adipose Tissue Graft Improves Early but not Late Stages of Nerve Regeneration.
We found that GFAP exhibited enhanced stability upon the addition of two equivalents of each ligands with ceftriaxone imparting a more spontaneous interactions and a more ordered complex system than phenytoin
Title: Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation.
reduction of GFAP+ cell density was in agreement with a lower expression of GFAP protein
Title: Anorexia Reduces GFAP+ Cell Density in the Rat Hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142195 (e-PCR)
- UniSTS:231445

Gfap (e-PCR), detects polymorphism
- UniSTS:255288

RH131871 (e-PCR)
- UniSTS:215154

Gfap (e-PCR), detects polymorphism
- UniSTS:275866

PMC125376P2 (e-PCR)
- UniSTS:270497

D10Wox35 (e-PCR)
- UniSTS:518591

D10Wox54 (e-PCR)
- UniSTS:518907

Homology

Homologs of the Gfap gene: The Gfap gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 381 organisms have orthologs with human gene Gfap
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect D-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within astrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intermediate filament-based process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chaperone-mediated autophagy	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of chaperone-mediated autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in astrocyte end-foot	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	TAS Traceable Author Statement more info
colocalizes_with lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glial fibrillary acidic protein

Names: glial fibrillary acidic protein alpha; glial fibrillary acidic protein delta; intermediate filament

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017009.2 → NP_058705.2 glial fibrillary acidic protein

See identical proteins and their annotated locations for NP_058705.2

Status: PROVISIONAL

Source sequence(s)

BC088851

UniProtKB/Swiss-Prot

P47819

Related

ENSRNOP00000032389.2, ENSRNOT00000034401.6

Conserved Domains (2) summary

pfam00038
Location:66 → 374

Filament; Intermediate filament protein

pfam04732
Location:4 → 64

Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

NC_051345.1 Reference mRatBN7.2 Primary Assembly

Range

87852891..87861631 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085178.1 → XP_038941106.1 glial fibrillary acidic protein isoform X1

Related

ENSRNOP00000076226.2, ENSRNOT00000093266.2

Conserved Domains (2) summary

pfam00038
Location:66 → 374

Filament; Intermediate filament protein

pfam04732
Location:4 → 64

Filament_head; Intermediate filament head (DNA binding) region