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Gfap glial fibrillary acidic protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 24387, updated on 22-Sep-2022

Summary

Official Symbol
Gfapprovided by RGD
Official Full Name
glial fibrillary acidic proteinprovided by RGD
Primary source
RGD:2679
See related
Ensembl:ENSRNOG00000002919 AllianceGenome:RGD:2679
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables integrin binding activity and kinase binding activity. A structural constituent of cytoskeleton. Involved in positive regulation of glial cell proliferation; regulation of chaperone-mediated autophagy; and response to wounding. Located in astrocyte projection and cytoplasmic side of lysosomal membrane. Biomarker of brain edema and retinal disease. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 849.3) See more
Orthologs
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Genomic context

See Gfap in Genome Data Viewer
Location:
10q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87852891..87861631, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90990762..90999435, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene coiled-coil domain containing 103 Neighboring gene family with sequence similarity 187, member A Neighboring gene kinesin family member 18B Neighboring gene 60S ribosomal protein L22-like 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect D-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of Schwann cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within astrocyte development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intermediate filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in intermediate filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in intermediate filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within intermediate filament-based process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Schwann cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chaperone-mediated autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of chaperone-mediated autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neurotransmitter uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in astrocyte end-foot ISO
Inferred from Sequence Orthology
more info
 
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane TAS
Traceable Author Statement
more info
 
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glial fibrillary acidic protein
Names
glial fibrillary acidic protein alpha
glial fibrillary acidic protein delta
intermediate filament

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017009.2NP_058705.2  glial fibrillary acidic protein

    See identical proteins and their annotated locations for NP_058705.2

    Status: PROVISIONAL

    Source sequence(s)
    BC088851
    UniProtKB/Swiss-Prot
    P47819, Q9Z2S0
    Related
    ENSRNOP00000032389.2, ENSRNOT00000034401.6
    Conserved Domains (2) summary
    pfam00038
    Location:66374
    Filament; Intermediate filament protein
    pfam04732
    Location:464
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    87852891..87861631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085178.1XP_038941106.1  glial fibrillary acidic protein isoform X1

    Related
    ENSRNOP00000076226.2, ENSRNOT00000093266.2
    Conserved Domains (2) summary
    pfam00038
    Location:66374
    Filament; Intermediate filament protein
    pfam04732
    Location:464
    Filament_head; Intermediate filament head (DNA binding) region