Gfap glial fibrillary acidic protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gfapprovided by RGD
Official Full Name: glial fibrillary acidic proteinprovided by RGD
Primary source: RGD:2679
See related: Ensembl:ENSRNOG00000002919
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: intermediate filament protein specific for astrocytes [RGD, Feb 2006]
Expression: Restricted expression toward (RPKM 849.3) See more
Orthologs: human mouse all

Genomic context

Location:: 10q32.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90990762..90999435, complement)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	10	NC_005109.3 (90763150..90771823, complement)

Chromosome 10 - NC_005109.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Results show that clustered regularly interspaced short palindromic repeats/Cas9-mediated SOX9 knockout not only inhibitedglial fibrillary acidic protein expression in rat Muller cells but also attenuated cell migration ability. These results suggest that inhibition of SOX9 activity may be a novel therapeutic strategy for reduction of glial cell activity.
Title: CRISPR-mediated SOX9 knockout inhibits GFAP expression in retinal glial (Müller) cells.
demonstrate increased DNA methylation coupled with decreased histone acetylation at the Gfap promoter leading to suppression of Gfap expression under maternal hypothyroidism
Title: Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism.
The present study found that social isolation during adolescence resulted in abnormal locomotor, emotional and cognitive behaviors and increased the expression of GFAP, ANXA2 and VIM in PFC of adult rats
Title: Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats.
GFAP-positive structures were present and exhibited a tendency to become linear on both sides, with an increased density on the left. NFAP-positive expression was present in the left treated limb with a disorganized pattern
Title: Adipose Tissue Graft Improves Early but not Late Stages of Nerve Regeneration.
We found that GFAP exhibited enhanced stability upon the addition of two equivalents of each ligands with ceftriaxone imparting a more spontaneous interactions and a more ordered complex system than phenytoin
Title: Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation.
reduction of GFAP+ cell density was in agreement with a lower expression of GFAP protein
Title: Anorexia Reduces GFAP+ Cell Density in the Rat Hippocampus.
Astrocyte expression of GLAST/GFAP was reduced via JAK1/JAK2/STAT3 signaling pathway after exposure to sevoflurane.
Title: Sevoflurane Inhibits Glutamate-Aspartate Transporter and Glial Fibrillary Acidic Protein Expression in Hippocampal Astrocytes of Neonatal Rats Through the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) Pathway.
Upon ependymal stem cells differentiation, Cx50 expression favors glial cell fate, since higher expression levels, endogenous or by over-expression of Cx50, augmented the expression of the astrocyte marker GFAP and impaired the neuronal marker Tuj1.
Title: Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation.
It is likely that a plastic change in GFAP expression in astrocytes selectively occurs around Oxytocin (OXT) neurons at proestrus and facilitates OXT release.
Title: Expression of glial fibrillary acidic protein in astrocytes of rat supraoptic nucleus throughout estrous cycle.
investigated temporal profile of astrocytic and neuronal injury markers after TBI; different mechanisms underlie clearance of UCH-L1 and GFAP in CSF and serum
Title: Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Variation

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Pathways from BioSystems

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Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
Nuclear signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142195 (e-PCR)
- UniSTS:231445

Gfap (e-PCR), detects polymorphism
- UniSTS:255288

RH131871 (e-PCR)
- UniSTS:215154

Gfap (e-PCR), detects polymorphism
- UniSTS:275866

PMC125376P2 (e-PCR)
- UniSTS:270497

D10Wox35 (e-PCR)
- UniSTS:518591

D10Wox54 (e-PCR)
- UniSTS:518907

Homology

Homologs of the Gfap gene: The Gfap gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 196 organisms have orthologs with human gene Gfap
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
identical protein binding	ISO Inferred from Sequence Orthology more info	PubMed
integrin binding	IDA Inferred from Direct Assay more info	PubMed
kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
structural molecule activity	IEA Inferred from Electronic Annotation more info
structural molecule activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
Bergmann glial cell differentiation	IEA Inferred from Electronic Annotation more info
Bergmann glial cell differentiation	ISO Inferred from Sequence Orthology more info	PubMed
astrocyte development	IEA Inferred from Electronic Annotation more info
astrocyte development	ISO Inferred from Sequence Orthology more info	PubMed
extracellular matrix organization	IEA Inferred from Electronic Annotation more info
extracellular matrix organization	ISO Inferred from Sequence Orthology more info	PubMed
intermediate filament organization	ISO Inferred from Sequence Orthology more info	PubMed
intermediate filament organization	ISS Inferred from Sequence or Structural Similarity more info
intermediate filament-based process	ISO Inferred from Sequence Orthology more info	PubMed
long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info	PubMed
negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info	PubMed
neuron projection regeneration	IEA Inferred from Electronic Annotation more info
neuron projection regeneration	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of Schwann cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of chaperone-mediated autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info	PubMed
regulation of neurotransmitter uptake	IEA Inferred from Electronic Annotation more info
regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info	PubMed
response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
astrocyte end-foot	IEA Inferred from Electronic Annotation more info
astrocyte end-foot	ISO Inferred from Sequence Orthology more info	PubMed
astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
astrocyte projection	ISO Inferred from Sequence Orthology more info	PubMed
cell body	IEA Inferred from Electronic Annotation more info
cell body	ISO Inferred from Sequence Orthology more info	PubMed
cell projection	ISO Inferred from Sequence Orthology more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
cytoplasmic side of lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	ISO Inferred from Sequence Orthology more info	PubMed
glial cell projection	ISO Inferred from Sequence Orthology more info	PubMed
intermediate filament	IEA Inferred from Electronic Annotation more info
intermediate filament	ISO Inferred from Sequence Orthology more info	PubMed
intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
colocalizes_with lysosome	ISO Inferred from Sequence Orthology more info	PubMed
membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: glial fibrillary acidic protein

Names: glial fibrillary acidic protein alpha; glial fibrillary acidic protein delta; intermediate filament

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017009.2 → NP_058705.2 glial fibrillary acidic protein

See identical proteins and their annotated locations for NP_058705.2

Status: PROVISIONAL

Source sequence(s)

BC088851

UniProtKB/Swiss-Prot

P47819

Related

ENSRNOP00000032389.2, ENSRNOT00000034401.5

Conserved Domains (2) summary

pfam00038
Location:66 → 374

Filament; Intermediate filament protein

pfam04732
Location:4 → 64

Filament_head; Intermediate filament head (DNA binding) region