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Meiosin meiosis initiator [ Mus musculus (house mouse) ]

Gene ID: 243866, updated on 5-Mar-2024

Summary

Official Symbol
Meiosinprovided by MGI
Official Full Name
meiosis initiatorprovided by MGI
Primary source
MGI:MGI:3647482
See related
Ensembl:ENSMUSG00000085601 AllianceGenome:MGI:3647482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bhmg1; Gm4969; EG243866; 9330180I18
Summary
Predicted to enable DNA binding activity and protein dimerization activity. Involved in several processes, including activation of meiosis; cellular response to retinoic acid; and gamete generation. Located in nucleus. Is expressed in genitourinary system. Orthologous to human MEIOSIN (meiosis initiator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 6.2), CNS E18 (RPKM 4.0) and 4 other tissues See more
Orthologs
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Genomic context

See Meiosin in Genome Data Viewer
Location:
7 A3; 7 9.46 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18832196..18852456, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19098271..19118531, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8152 Neighboring gene dystrophia myotonica-containing WD repeat motif Neighboring gene dystrophia myotonica-protein kinase Neighboring gene microRNA 3100 Neighboring gene STARR-positive B cell enhancer ABC_E9285 Neighboring gene sine oculis-related homeobox 5 Neighboring gene STARR-positive B cell enhancer ABC_E287 Neighboring gene F-box protein 46 Neighboring gene STARR-positive B cell enhancer ABC_E10426 Neighboring gene glutaminyl-peptide cyclotransferase-like Neighboring gene STARR-positive B cell enhancer ABC_E1081

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
meiosis initiator protein
Names
basic helix-loop-helix and HMG box domain-containing protein 1
basic helix-loop-helix and HMG-box containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370811.1NP_001357740.1  meiosis initiator protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC145199
    UniProtKB/Swiss-Prot
    A0A5K7RLP0, D3YZT1
    Conserved Domains (3) summary
    COG5648
    Location:416539
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:484539
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl00081
    Location:2473
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  2. NM_001370812.1NP_001357741.1  meiosis initiator protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC145199
    Conserved Domains (3) summary
    COG5648
    Location:395512
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:457512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl00081
    Location:2473
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18832196..18852456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153082.1XP_036008975.1  meiosis initiator protein isoform X9

    Conserved Domains (2) summary
    COG5648
    Location:156279
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:224279
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  2. XM_030242562.2XP_030098422.1  meiosis initiator protein isoform X8

    Conserved Domains (2) summary
    COG5648
    Location:215338
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:283338
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  3. XM_006540472.3XP_006540535.1  meiosis initiator protein isoform X9

    See identical proteins and their annotated locations for XP_006540535.1

    Conserved Domains (2) summary
    COG5648
    Location:156279
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:224279
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  4. XM_006540471.3XP_006540534.1  meiosis initiator protein isoform X7

    See identical proteins and their annotated locations for XP_006540534.1

    Conserved Domains (2) summary
    COG5648
    Location:235358
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:303358
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  5. XM_011250751.3XP_011249053.1  meiosis initiator protein isoform X1

    Conserved Domains (3) summary
    COG5648
    Location:412535
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:480535
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl00081
    Location:2473
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  6. XM_011250752.3XP_011249054.1  meiosis initiator protein isoform X2

    Conserved Domains (3) summary
    COG5648
    Location:404527
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:472527
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl00081
    Location:2473
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  7. XM_011250756.3XP_011249058.1  meiosis initiator protein isoform X6

    Conserved Domains (2) summary
    cd00084
    Location:438493
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl00081
    Location:2473
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  8. XM_011250755.3XP_011249057.1  meiosis initiator protein isoform X5

    Conserved Domains (2) summary
    cd00084
    Location:439494
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl00081
    Location:2473
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  9. XM_011250754.3XP_011249056.1  meiosis initiator protein isoform X4

    Conserved Domains (2) summary
    cd00084
    Location:460515
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl00081
    Location:2473
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  10. XM_011250753.3XP_011249055.1  meiosis initiator protein isoform X3

    UniProtKB/TrEMBL
    D3YZT1
    Related
    ENSMUSP00000115575.3, ENSMUST00000141380.3
    Conserved Domains (3) summary
    COG5648
    Location:399516
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:461516
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl00081
    Location:2473
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  11. XM_030242563.2XP_030098423.1  meiosis initiator protein isoform X9

    Conserved Domains (2) summary
    COG5648
    Location:156279
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:224279
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  12. XM_030242561.2XP_030098421.1  meiosis initiator protein isoform X7

    Conserved Domains (2) summary
    COG5648
    Location:235358
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:303358
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...