Meiosin meiosis initiator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Meiosinprovided by MGI
Official Full Name: meiosis initiatorprovided by MGI
Primary source: MGI:MGI:3647482
See related: Ensembl:ENSMUSG00000085601 AllianceGenome:MGI:3647482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bhmg1; Gm4969; EG243866; 9330180I18
Summary: Predicted to enable DNA binding activity and protein dimerization activity. Involved in several processes, including activation of meiosis; cellular response to retinoic acid; and gamete generation. Located in nucleus. Is expressed in genitourinary system. Orthologous to human MEIOSIN (meiosis initiator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 6.2), CNS E18 (RPKM 4.0) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 A3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18832196..18852456, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19098271..19118531, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Switching defective/sucrose non-fermenting chromatin remodeling complex coordinates meiotic gene activation via promoter remodeling and Meiosin activation in female germline.
Title: Switching defective/sucrose non-fermenting chromatin remodeling complex coordinates meiotic gene activation via promoter remodeling and Meiosin activation in female germline.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Homology

Homologs of the Meiosin gene: The Meiosin gene is conserved in chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 228 organisms have orthologs with human gene Meiosin
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: meiosis initiator protein; basic helix-loop-helix and HMG box domain-containing protein 1

Names: basic helix-loop-helix and HMG-box containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370811.1 → NP_001357740.1 meiosis initiator protein isoform 1

Status: VALIDATED

Source sequence(s)

AC145199

UniProtKB/Swiss-Prot

D3YZT1

Conserved Domains (3) summary

COG5648
Location:416 → 539

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:484 → 539

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00081
Location:24 → 73

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
NM_001370812.1 → NP_001357741.1 meiosis initiator protein isoform 2

Status: VALIDATED

Source sequence(s)

AC145199

Conserved Domains (3) summary

COG5648
Location:395 → 512

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:457 → 512

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00081
Location:24 → 73

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

18832196..18852456 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153082.1 → XP_036008975.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X9

Conserved Domains (2) summary

COG5648
Location:156 → 279

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:224 → 279

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_030242562.2 → XP_030098422.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X8

Conserved Domains (2) summary

COG5648
Location:215 → 338

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:283 → 338

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_006540472.3 → XP_006540535.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X9

See identical proteins and their annotated locations for XP_006540535.1

Conserved Domains (2) summary

COG5648
Location:156 → 279

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:224 → 279

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_006540471.3 → XP_006540534.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X7

See identical proteins and their annotated locations for XP_006540534.1

Conserved Domains (2) summary

COG5648
Location:235 → 358

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:303 → 358

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_011250751.3 → XP_011249053.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X1

Conserved Domains (3) summary

COG5648
Location:412 → 535

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:480 → 535

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00081
Location:24 → 73

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_011250752.3 → XP_011249054.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X2

Conserved Domains (3) summary

COG5648
Location:404 → 527

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:472 → 527

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00081
Location:24 → 73

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_011250756.3 → XP_011249058.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X6

Conserved Domains (2) summary

cd00084
Location:438 → 493

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00081
Location:24 → 73

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_011250755.3 → XP_011249057.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X5

Conserved Domains (2) summary

cd00084
Location:439 → 494

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00081
Location:24 → 73

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_011250754.3 → XP_011249056.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X4

Conserved Domains (2) summary

cd00084
Location:460 → 515

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00081
Location:24 → 73

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_011250753.3 → XP_011249055.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

D3YZT1

Related

ENSMUSP00000115575.3, ENSMUST00000141380.3

Conserved Domains (3) summary

COG5648
Location:399 → 516

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:461 → 516

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00081
Location:24 → 73

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_030242563.2 → XP_030098423.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X9

Conserved Domains (2) summary

COG5648
Location:156 → 279

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:224 → 279

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_030242561.2 → XP_030098421.1 basic helix-loop-helix and HMG box domain-containing protein 1 isoform X7

Conserved Domains (2) summary

COG5648
Location:235 → 358

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:303 → 358

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...