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Plxna4 plexin A4 [ Mus musculus (house mouse) ]

Gene ID: 243743, updated on 15-Nov-2022

Summary

Official Symbol
Plxna4provided by MGI
Official Full Name
plexin A4provided by MGI
Primary source
MGI:MGI:2179061
See related
Ensembl:ENSMUSG00000029765 AllianceGenome:MGI:2179061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plxa4; mKIAA1550; 9330117B14
Summary
Enables semaphorin receptor activity. Involved in axon guidance; cranial nerve structural organization; and embryonic heart tube development. Acts upstream of or within several processes, including nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; nervous system; and sensory organ. Orthologous to human PLXNA4 (plexin A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 7.4), CNS E14 (RPKM 6.4) and 16 other tissues See more
Orthologs
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Genomic context

See Plxna4 in Genome Data Viewer
Location:
6; 6 A3.3
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (32121478..32565127, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (32144543..32588192, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012A03 gene Neighboring gene predicted gene 13850 Neighboring gene plexin A4, opposite strand 1 Neighboring gene predicted gene, 46956 Neighboring gene predicted gene, 32007

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1550

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior commissure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branchiomotor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemorepulsion of branchiomotor axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cranial nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic heart tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within facial nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in facial nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glossopharyngeal nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of synapse structure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maintenance of synapse structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within postganglionic parasympathetic fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of negative chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within semaphorin-plexin signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic neuron axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within trigeminal nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trigeminal nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vagus nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cerebellar climbing fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cerebellar climbing fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175750.3NP_786926.2  plexin-A4 precursor

    See identical proteins and their annotated locations for NP_786926.2

    Status: VALIDATED

    Source sequence(s)
    AB073228, AC153629, AC158678, BF456700
    Consensus CDS
    CCDS19985.2
    UniProtKB/Swiss-Prot
    Q80UG2, Q8BKK9
    Related
    ENSMUSP00000110748.3, ENSMUST00000115096.4
    Conserved Domains (8) summary
    cd11274
    Location:38510
    Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4
    smart00423
    Location:509547
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00603
    Location:11411221
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9541037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:857952
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10391139
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:803855
    PSI; Plexin repeat
    pfam08337
    Location:13101863
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    32121478..32565127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)