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Fst follistatin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24373, updated on 22-May-2018
Symbol
Fstprovided by RGD
Full Name
follistatinprovided by RGD
Primary source
RGD:2633
See related
Ensembl:ENSRNOG00000011631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FS; FOL1; Fst-288; RATFOL1
Summary
binds activin and inhibits activin-mediated signaling pathways [RGD, Feb 2006]
Expression
Biased expression in Uterus (RPKM 36.4), Muscle (RPKM 32.2) and 8 other tissues See more
Orthologs
See Fst in Genome Data Viewer
Location:
2q14
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (46537589..46544813, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (65576721..65583918, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene olfactory receptor 147-like Neighboring gene NADH:ubiquinone oxidoreductase subunit S4 Neighboring gene uncharacterized LOC103691459 Neighboring gene molybdenum cofactor synthesis 2

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
activin binding ISO
Inferred from Sequence Orthology
more info
 
activin binding TAS
Traceable Author Statement
more info
PubMed 
heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
female gonad development ISO
Inferred from Sequence Orthology
more info
 
gamete generation ISO
Inferred from Sequence Orthology
more info
 
hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of follicle-stimulating hormone secretion TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
pattern specification process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
 
skeletal system development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
follistatin
Names
activin-binding protein
follistatin-A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012561.2NP_036693.1  follistatin precursor

    See identical proteins and their annotated locations for NP_036693.1

    Status: VALIDATED

    Source sequence(s)
    AC133021
    UniProtKB/Swiss-Prot
    P21674
    Related
    ENSRNOP00000015680.1, ENSRNOT00000015680.4
    Conserved Domains (2) summary
    smart00274
    Location:94117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    46537589..46544813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231953.3XP_006232015.1  follistatin isoform X1

    Conserved Domains (2) summary
    smart00274
    Location:94117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
  2. XM_006231954.3XP_006232016.1  follistatin isoform X2

    Conserved Domains (2) summary
    smart00274
    Location:94117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    41883386..41889989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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