U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppp1r9a protein phosphatase 1, regulatory subunit 9A [ Mus musculus (house mouse) ]

Gene ID: 243725, updated on 5-Jan-2023

Summary

Official Symbol
Ppp1r9aprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 9Aprovided by MGI
Primary source
MGI:MGI:2442401
See related
Ensembl:ENSMUSG00000032827 AllianceGenome:MGI:2442401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NRB; 5330407E15; neurabin-I; 2810430P21Rik; 4930518N04Rik; A230094E16Rik
Summary
Predicted to enable several functions, including enzyme binding activity; protein C-terminus binding activity; and transmembrane transporter binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within actin filament organization and calcium-mediated signaling. Located in cortical actin cytoskeleton; dendritic spine; and filopodium. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; hemolymphoid system gland; and skeletal muscle. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 12.5), frontal lobe adult (RPKM 11.0) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ppp1r9a in Genome Data Viewer
Location:
6 A1; 6 1.86 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (4902702..5165661)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (4902872..5165661)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20714 Neighboring gene glia maturation factor, gamma, pseudogene Neighboring gene predicted gene, 52886 Neighboring gene predicted gene, 46949 Neighboring gene paraoxonase 1 Neighboring gene paraoxonase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1222

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin filament organization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine neck ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in growth cone lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neurabin-1
Names
neural tissue-specific F-actin binding protein
protein phosphatase 1, regulatory (inhibitor) subunit 9A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363809.1NP_001350738.1  neurabin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC068500, AC074225
    Consensus CDS
    CCDS19897.1
    UniProtKB/TrEMBL
    Q7TN74
    Related
    ENSMUSP00000135629.2, ENSMUST00000175889.8
    Conserved Domains (4) summary
    cd09512
    Location:9831052
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659927
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  2. NM_001401494.1NP_001388423.1  neurabin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068500, AC074225
  3. NM_001401496.1NP_001388425.1  neurabin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068500, AC074225
  4. NM_181595.4NP_853626.1  neurabin-1 isoform 1

    See identical proteins and their annotated locations for NP_853626.1

    Status: VALIDATED

    Source sequence(s)
    AC068500, AC074225
    Consensus CDS
    CCDS19897.1
    UniProtKB/TrEMBL
    Q7TN74
    Related
    ENSMUSP00000046906.3, ENSMUST00000035813.9
    Conserved Domains (4) summary
    cd09512
    Location:9831052
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659927
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain

RNA

  1. NR_156747.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068500, AC074225
    Related
    ENSMUST00000164110.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    4902702..5165661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505071.5XP_006505134.1  neurabin-1 isoform X1

    Conserved Domains (4) summary
    cd09512
    Location:12101279
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681926
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  2. XM_036166122.1XP_036022015.1  neurabin-1 isoform X3

    Conserved Domains (4) summary
    cd09512
    Location:11881257
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659904
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  3. XM_036166126.1XP_036022019.1  neurabin-1 isoform X9

    Conserved Domains (4) summary
    cd09512
    Location:9311000
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:606875
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  4. XM_006505070.3XP_006505133.1  neurabin-1 isoform X1

    See identical proteins and their annotated locations for XP_006505133.1

    Conserved Domains (4) summary
    cd09512
    Location:12101279
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681926
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  5. XM_006505073.4XP_006505136.1  neurabin-1 isoform X2

    See identical proteins and their annotated locations for XP_006505136.1

    Conserved Domains (4) summary
    cd09512
    Location:12021271
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681926
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  6. XM_006505078.4XP_006505141.1  neurabin-1 isoform X6

    Related
    ENSMUSP00000134937.2, ENSMUST00000176263.8
    Conserved Domains (4) summary
    cd09512
    Location:10051074
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681949
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  7. XM_006505075.3XP_006505138.1  neurabin-1 isoform X3

    Conserved Domains (4) summary
    cd09512
    Location:11881257
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659904
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  8. XM_006505076.3XP_006505139.1  neurabin-1 isoform X4

    UniProtKB/TrEMBL
    H3BJD6
    Related
    ENSMUSP00000134943.2, ENSMUST00000177456.8
    Conserved Domains (4) summary
    cd09512
    Location:11801249
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659904
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  9. XM_006505080.3XP_006505143.1  neurabin-1 isoform X8

    Conserved Domains (4) summary
    cd09512
    Location:9751044
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659927
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  10. XM_036166124.1XP_036022017.1  neurabin-1 isoform X5

    Conserved Domains (4) summary
    cd09512
    Location:11361205
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:606852
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  11. XM_006505082.4XP_006505145.1  neurabin-1 isoform X10

    Conserved Domains (3) summary
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681843
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  12. XM_017321591.3XP_017177080.1  neurabin-1 isoform X11

    Related
    ENSMUSP00000135485.2, ENSMUST00000177153.8
    Conserved Domains (3) summary
    cd00992
    Location:506589
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02168
    Location:659821
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  13. XM_006505072.4XP_006505135.1  neurabin-1 isoform X1

    See identical proteins and their annotated locations for XP_006505135.1

    Conserved Domains (4) summary
    cd09512
    Location:12101279
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681926
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  14. XM_036166123.1XP_036022016.1  neurabin-1 isoform X3

    Conserved Domains (4) summary
    cd09512
    Location:11881257
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659904
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  15. XM_036166125.1XP_036022018.1  neurabin-1 isoform X7

    UniProtKB/TrEMBL
    Q7TN74
    Conserved Domains (4) summary
    cd09512
    Location:9831052
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659927
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  16. XM_036166127.1XP_036022020.1  neurabin-1 isoform X12

    Conserved Domains (3) summary
    cd09512
    Location:667736
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    cd00992
    Location:1068
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02168
    Location:138383
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_003956199.2 RNA Sequence

  2. XR_004942955.1 RNA Sequence