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Styk1 serine/threonine/tyrosine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 243659, updated on 6-Jun-2024

Summary

Official Symbol
Styk1provided by MGI
Official Full Name
serine/threonine/tyrosine kinase 1provided by MGI
Primary source
MGI:MGI:2141396
See related
Ensembl:ENSMUSG00000032899 AllianceGenome:MGI:2141396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nok; 9130025L13
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within phosphorylation. Predicted to be located in plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in brain and olfactory epithelium. Orthologous to human STYK1 (serine/threonine/tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 8.7), colon adult (RPKM 6.8) and 6 other tissues See more
Orthologs
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Genomic context

See Styk1 in Genome Data Viewer
Location:
6 F3; 6 63.44 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (131276096..131330532, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (131299133..131353836, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5582 Neighboring gene STARR-positive B cell enhancer ABC_E9280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131243245-131243354 Neighboring gene mago homolog B, exon junction complex core component Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131303559-131303777 Neighboring gene STARR-seq mESC enhancer starr_17494 Neighboring gene Y box protein 3 Neighboring gene STARR-positive B cell enhancer mm9_chr6:131338351-131338652 Neighboring gene STARR-seq mESC enhancer starr_17495 Neighboring gene predicted gene, 22362 Neighboring gene STARR-seq mESC enhancer starr_17496 Neighboring gene ring finger and WD repeat domain 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein kinase STYK1
Names
NOK kinase
mNOK
novel oncogene with kinase domain
NP_001398609.1
NP_001398610.1
NP_001398611.1
NP_001398612.1
NP_001398613.1
NP_001398614.1
NP_766479.1
XP_006506194.1
XP_006506195.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411680.1NP_001398609.1  tyrosine-protein kinase STYK1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
  2. NM_001411681.1NP_001398610.1  tyrosine-protein kinase STYK1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
  3. NM_001411682.1NP_001398611.1  tyrosine-protein kinase STYK1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
  4. NM_001411683.1NP_001398612.1  tyrosine-protein kinase STYK1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
  5. NM_001411684.1NP_001398613.1  tyrosine-protein kinase STYK1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    Related
    ENSMUSP00000112900.2, ENSMUST00000121078.2
  6. NM_001411685.1NP_001398614.1  tyrosine-protein kinase STYK1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
  7. NM_172891.3NP_766479.1  tyrosine-protein kinase STYK1 isoform a

    See identical proteins and their annotated locations for NP_766479.1

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    Consensus CDS
    CCDS20604.1
    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
    Related
    ENSMUSP00000044098.2, ENSMUST00000049150.8
    Conserved Domains (1) summary
    cl21453
    Location:123388
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    131276096..131330532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506131.4XP_006506194.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_006506194.1

    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
    Conserved Domains (1) summary
    cl21453
    Location:123388
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006506132.4XP_006506195.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_006506195.1

    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
    Conserved Domains (1) summary
    cl21453
    Location:123388
    PKc_like; Protein Kinases, catalytic domain