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Ets1 ETS proto-oncogene 1, transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24356, updated on 3-Apr-2018
Official Symbol
Ets1provided by RGD
Official Full Name
ETS proto-oncogene 1, transcription factorprovided by RGD
Primary source
RGD:2583
See related
Ensembl:ENSRNOG00000008941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tpl1; Ets-1; Etsoncb
Summary
activates transcription of cyclin-dependent kinase inhibitor p21WAF1/Cip1; plays a role in inhibition of apoptosis [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 966.3), Spleen (RPKM 625.2) and 7 other tissues See more
Orthologs
Location:
8q21
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33756634..33879625)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (33798598..33921593)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily J member 1 Neighboring gene uncharacterized LOC108351670 Neighboring gene Fli-1 proto-oncogene, ETS transcription factor Neighboring gene uncharacterized LOC102552230 Neighboring gene uncharacterized LOC102552355 Neighboring gene similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC124638

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
PML body organization IEA
Inferred from Electronic Annotation
more info
 
PML body organization ISO
Inferred from Sequence Orthology
more info
 
angiogenesis involved in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
cell motility IEA
Inferred from Electronic Annotation
more info
 
cell motility ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
estrous cycle IEP
Inferred from Expression Pattern
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
hypothalamus development IEP
Inferred from Expression Pattern
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular component movement ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte adhesion to vascular endothelial cell IEA
Inferred from Electronic Annotation
more info
 
positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
pri-miRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
response to laminar fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein C-ets-1
Names
Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1)
p54
v-ets avian erythroblastosis virus E26 oncogene homolog 1
v-ets erythroblastosis virus E26 oncogene homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012555.2NP_036687.1  protein C-ets-1

    See identical proteins and their annotated locations for NP_036687.1

    Status: VALIDATED

    Source sequence(s)
    AABR07069611, BC101927, L20681
    UniProtKB/Swiss-Prot
    P41156
    Related
    ENSRNOP00000011925.4, ENSRNOT00000011925.4
    Conserved Domains (2) summary
    cd08542
    Location:51138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:334418
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    33756634..33879625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595451.1XP_017450940.1  protein C-ets-1 isoform X1

  2. XM_017595452.1XP_017450941.1  protein C-ets-1 isoform X2

  3. XM_017595453.1XP_017450942.1  protein C-ets-1 isoform X3

  4. XM_006242752.1XP_006242814.1  protein C-ets-1 isoform X4

    See identical proteins and their annotated locations for XP_006242814.1

    Conserved Domains (2) summary
    cd08542
    Location:51138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:247331
    ETS; erythroblast transformation specific domain

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    32555513..32617691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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