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Cfap100 cilia and flagella associated protein 100 [ Mus musculus (house mouse) ]

Gene ID: 243538, updated on 8-Apr-2026
Official Symbol
Cfap100provided by MGI
Official Full Name
cilia and flagella associated protein 100provided by MGI
Primary source
MGI:MGI:2141635
See related
Ensembl:ENSMUSG00000048794 AllianceGenome:MGI:2141635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc37; C030041G11Rik; C230069K22Rik
Summary
Predicted to enable dynein complex binding activity. Predicted to be involved in cilium movement and inner dynein arm assembly. Predicted to be located in axonemal doublet microtubule and motile cilium. Predicted to be active in ciliary basal body. Is expressed in central nervous system and nose. Orthologous to human CFAP100 (cilia and flagella associated protein 100). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in testis adult (RPKM 13.0), CNS E18 (RPKM 2.8) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Cfap100 in Genome Data Viewer
Location:
6 D1; 6 40.16 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90380713..90412379, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90403731..90429768, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene urocanase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10392 Neighboring gene STARR-seq mESC enhancer starr_16614 Neighboring gene STARR-seq mESC enhancer starr_16615 Neighboring gene ZXD family zinc finger C Neighboring gene predicted gene, 53295 Neighboring gene STARR-seq mESC enhancer starr_16619 Neighboring gene Kruppel-like transcription factor 15 Neighboring gene STARR-seq mESC enhancer starr_16625 Neighboring gene STARR-seq mESC enhancer starr_16627 Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene predicted gene 15756

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development. Sun S, et al. Nat Commun, 2025 Jul 1. PMID 40593606, Free PMC Article
  2. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
  3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inner dynein arm assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skin epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axonemal doublet microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
cilia- and flagella-associated protein 100
Names
coiled-coil domain containing 37
coiled-coil domain-containing protein 37

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173775.3 → NP_776136.2  cilia- and flagella-associated protein 100

    Status: VALIDATED

    Source sequence(s)
    AC163346
    Consensus CDS
    CCDS51849.1
    UniProtKB/Swiss-Prot
    E9PYA2, Q6AXD6, Q80VN0
    Related
    ENSMUSP00000126515.2, ENSMUST00000165673.5
    Conserved Domains (1) summary
    pfam13863
    Location:154 → 272
    DUF4200; Domain of unknown function (DUF4200)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    90380713..90412379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241338.4 → XP_011239640.1  cilia- and flagella-associated protein 100 isoform X1

    See identical proteins and their annotated locations for XP_011239640.1

    Conserved Domains (1) summary
    pfam13863
    Location:154 → 272
    DUF4200; Domain of unknown function (DUF4200)

  2. XM_030255376.2 → XP_030111236.1  cilia- and flagella-associated protein 100 isoform X7

    Conserved Domains (1) summary
    pfam13863
    Location:1 → 118
    DUF4200; Domain of unknown function (DUF4200)

  3. XM_017321584.3 → XP_017177073.1  cilia- and flagella-associated protein 100 isoform X1

    Conserved Domains (1) summary
    pfam13863
    Location:154 → 272
    DUF4200; Domain of unknown function (DUF4200)

  4. XM_030255375.2 → XP_030111235.1  cilia- and flagella-associated protein 100 isoform X6

    Conserved Domains (1) summary
    pfam13863
    Location:92 → 210
    DUF4200; Domain of unknown function (DUF4200)

  5. XM_006506095.5 → XP_006506158.1  cilia- and flagella-associated protein 100 isoform X5

    See identical proteins and their annotated locations for XP_006506158.1

    Conserved Domains (1) summary
    pfam13863
    Location:92 → 210
    DUF4200; Domain of unknown function (DUF4200)

  6. XM_030255377.2 → XP_030111237.1  cilia- and flagella-associated protein 100 isoform X8

    UniProtKB/TrEMBL
    A0A171EBL0
    Conserved Domains (1) summary
    pfam13863
    Location:1 → 118
    DUF4200; Domain of unknown function (DUF4200)

  7. XM_030255373.2 → XP_030111233.1  cilia- and flagella-associated protein 100 isoform X4

    Conserved Domains (1) summary
    pfam13863
    Location:127 → 245
    DUF4200; Domain of unknown function (DUF4200)

  8. XM_011241340.3 → XP_011239642.1  cilia- and flagella-associated protein 100 isoform X3

    Conserved Domains (1) summary
    pfam13863
    Location:127 → 245
    DUF4200; Domain of unknown function (DUF4200)

  9. XM_011241339.4 → XP_011239641.1  cilia- and flagella-associated protein 100 isoform X2

    Conserved Domains (1) summary
    pfam13863
    Location:153 → 271
    DUF4200; Domain of unknown function (DUF4200)

  10. XM_030255374.2 → XP_030111234.1  cilia- and flagella-associated protein 100 isoform X6

    Conserved Domains (1) summary
    pfam13863
    Location:92 → 210
    DUF4200; Domain of unknown function (DUF4200)

  11. XM_030255378.2 → XP_030111238.1  cilia- and flagella-associated protein 100 isoform X8

    UniProtKB/TrEMBL
    A0A171EBL0
    Related
    ENSMUSP00000059976.6, ENSMUST00000062750.12
    Conserved Domains (1) summary
    pfam13863
    Location:1 → 118
    DUF4200; Domain of unknown function (DUF4200)

  12. XM_030255372.2 → XP_030111232.1  cilia- and flagella-associated protein 100 isoform X1

    Conserved Domains (1) summary
    pfam13863
    Location:154 → 272
    DUF4200; Domain of unknown function (DUF4200)

  13. XM_036166116.1 → XP_036022009.1  cilia- and flagella-associated protein 100 isoform X9

    Conserved Domains (1) summary
    pfam13863
    Location:14 → 66
    DUF4200; Domain of unknown function (DUF4200)

  14. XM_030255384.2 → XP_030111244.1  cilia- and flagella-associated protein 100 isoform X10

    Conserved Domains (1) summary
    pfam13863
    Location:14 → 66
    DUF4200; Domain of unknown function (DUF4200)

  15. XM_011241341.4 → XP_011239643.1  cilia- and flagella-associated protein 100 isoform X5

    See identical proteins and their annotated locations for XP_011239643.1

    Conserved Domains (1) summary
    pfam13863
    Location:92 → 210
    DUF4200; Domain of unknown function (DUF4200)

  16. XM_036166115.1 → XP_036022008.1  cilia- and flagella-associated protein 100 isoform X8

    UniProtKB/TrEMBL
    A0A171EBL0
    Conserved Domains (1) summary
    pfam13863
    Location:1 → 118
    DUF4200; Domain of unknown function (DUF4200)

  17. XM_011241342.4 → XP_011239644.1  cilia- and flagella-associated protein 100 isoform X5

    See identical proteins and their annotated locations for XP_011239644.1

    Conserved Domains (1) summary
    pfam13863
    Location:92 → 210
    DUF4200; Domain of unknown function (DUF4200)

  18. XM_036166113.1 → XP_036022006.1  cilia- and flagella-associated protein 100 isoform X7

    Conserved Domains (1) summary
    pfam13863
    Location:1 → 118
    DUF4200; Domain of unknown function (DUF4200)

  19. XM_036166112.1 → XP_036022005.1  cilia- and flagella-associated protein 100 isoform X5

    Conserved Domains (1) summary
    pfam13863
    Location:92 → 210
    DUF4200; Domain of unknown function (DUF4200)

  20. XM_036166117.1 → XP_036022010.1  cilia- and flagella-associated protein 100 isoform X9

    Conserved Domains (1) summary
    pfam13863
    Location:14 → 66
    DUF4200; Domain of unknown function (DUF4200)

  21. XM_011241348.1 → XP_011239650.1  cilia- and flagella-associated protein 100 isoform X9

    See identical proteins and their annotated locations for XP_011239650.1

    Conserved Domains (1) summary
    pfam13863
    Location:14 → 66
    DUF4200; Domain of unknown function (DUF4200)

  22. XM_036166118.1 → XP_036022011.1  cilia- and flagella-associated protein 100 isoform X9

    Conserved Domains (1) summary
    pfam13863
    Location:14 → 66
    DUF4200; Domain of unknown function (DUF4200)

  23. XM_036166114.1 → XP_036022007.1  cilia- and flagella-associated protein 100 isoform X7

    Conserved Domains (1) summary
    pfam13863
    Location:1 → 118
    DUF4200; Domain of unknown function (DUF4200)

RNA

  1. XR_003956196.2 RNA Sequence

  2. XR_001785131.3 RNA Sequence

  3. XR_001785132.3 RNA Sequence

  4. XR_001785130.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VN0.2 GenPept UniProtKB/Swiss-Prot:Q80VN0

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