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Igk immunoglobulin kappa chain complex [ Mus musculus (house mouse) ]

Gene ID: 243469, updated on 12-May-2024

Summary

Official Symbol
Igkprovided by MGI
Official Full Name
immunoglobulin kappa chain complexprovided by MGI
Primary source
MGI:MGI:96494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kappa
Summary
Summary:Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the kappa light chain locus from the C57BL/6J inbred mouse strain. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments in this cluster are incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Jul 2008]
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Genomic context

See Igk in Genome Data Viewer
Location:
6 C1; 6 30.89 cM
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67532620..70703738)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67555636..70726754)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16185 Neighboring gene STARR-seq mESC enhancer starr_16186 Neighboring gene myc induced nuclear antigen pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:67483136-67483367 Neighboring gene STARR-seq mESC enhancer starr_16187 Neighboring gene STARR-seq mESC enhancer starr_16188 Neighboring gene STARR-seq mESC enhancer starr_16189 Neighboring gene STARR-seq mESC enhancer starr_16190 Neighboring gene STARR-positive B cell enhancer mm9_chr6:67623335-67623635 Neighboring gene STARR-seq mESC enhancer starr_16191 Neighboring gene immunoglobulin kappa chain variable 2-137 Neighboring gene immunoglobulin kappa chain variable 14-134-1 Neighboring gene immunoglobulin kappa chain variable 1-136 Neighboring gene ribosomal protein L18A, pseudogene 2 Neighboring gene interleukin 23 receptor Neighboring gene immunoglobulin kappa variable 1-135 Neighboring gene tumor-associated calcium signal transducer 2 Neighboring gene STARR-seq mESC enhancer starr_16192 Neighboring gene immunoglobulin kappa chain variable 17-134 Neighboring gene ribosomal protein L18A, pseudogene 3 Neighboring gene immunoglobulin kappa variable 1-133 Neighboring gene immunoglobulin kappa chain variable 14-126-1 Neighboring gene immunoglobulin kappa variable 14-130 Neighboring gene STARR-seq mESC enhancer starr_16194 Neighboring gene immunoglobulin kappa variable 1-132 Neighboring gene immunoglobulin kappa variable 1-131 Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_16196 Neighboring gene predicted gene, 38573 Neighboring gene immunoglobulin kappa variable 17-127 Neighboring gene immunoglobulin kappa variable 9-129 Neighboring gene immunoglobulin kappa chain variable 9-128 Neighboring gene immunoglobulin kappa variable 14-126 Neighboring gene immunoglobulin kappa variable 11-125 Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene EGF-like repeats and discoidin I-like domains 3 pseudogene Neighboring gene predicted gene, 22425 Neighboring gene predicted gene, 24911 Neighboring gene immunoglobulin kappa chain variable 14-118-2 Neighboring gene immunoglobulin kappa chain variable 9-124 Neighboring gene immunoglobulin kappa chain variable 14-118-1 Neighboring gene immunoglobulin kappa variable 9-123 Neighboring gene immunoglobulin kappa variable 17-121 Neighboring gene predicted gene, 25910 Neighboring gene immunoglobulin kappa chain variable 1-122 Neighboring gene ARP2 actin-related protein 2 homolog pseudogene Neighboring gene immunoglobulin kappa chain variable 9-120 Neighboring gene immunoglobulin kappa chain variable 9-119 Neighboring gene immunoglobulin kappa chain variable 11-118 Neighboring gene immunoglobulin kappa variable 1-117 Neighboring gene immunoglobulin kappa chain variable Neighboring gene immunoglobulin kappa variable 2-116 Neighboring gene immunoglobulin kappa variable 1-115 Neighboring gene STARR-positive B cell enhancer mm9_chr6:68252207-68252508 Neighboring gene immunoglobulin kappa chain variable 2-113 Neighboring gene STARR-seq mESC enhancer starr_16198 Neighboring gene immunoglobulin kappa variable 14-111 Neighboring gene immunoglobulin kappa variable 2-112 Neighboring gene nucleosome assembly protein 1-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16199 Neighboring gene STARR-seq mESC enhancer starr_16200 Neighboring gene immunoglobulin kappa variable 1-110 Neighboring gene immunoglobulin kappa variable 11-106 Neighboring gene immunoglobulin kappa variable 2-109 Neighboring gene immunoglobulin kappa variable 1-108 Neighboring gene immunoglobulin kappa variable 2-107 Neighboring gene immunoglobulin kappa chain variable 20-101-2 Neighboring gene immunoglobulin kappa chain variable 15-101-1 Neighboring gene immunoglobulin kappa chain variable 2-105 Neighboring gene predicted gene, 25436 Neighboring gene cortactin pseudogene Neighboring gene immunoglobulin kappa variable 16-104 Neighboring gene immunoglobulin kappa chain variable 15-103 Neighboring gene immunoglobulin kappa chain variable 15-102 Neighboring gene immunoglobulin kappa chain variable 15-101 Neighboring gene immunoglobulin kappa chain variable 14-100 Neighboring gene cortactin pseudogene Neighboring gene immunoglobulin kappa variable 12-98 Neighboring gene immunoglobulin kappa variable 1-99 Neighboring gene immunoglobulin kappa chain variable 15-97 Neighboring gene immunoglobulin kappa variable 2-95-2 Neighboring gene immunoglobulin kappa chain variable Neighboring gene predicted gene, 25833 Neighboring gene immunoglobulin kappa variable 10-96 Neighboring gene immunoglobulin kappa chain variable 2-93-1 Neighboring gene STARR-seq mESC enhancer starr_16202 Neighboring gene STARR-seq mESC enhancer starr_16201 Neighboring gene immunoglobulin kappa variable 10-95 Neighboring gene immunoglobulin kappa variable 10-94 Neighboring gene STARR-seq mESC enhancer starr_16204 Neighboring gene immunoglobulin kappa chain variable 13-89-1 Neighboring gene immunoglobulin kappa chain variable 19-93 Neighboring gene immunoglobulin kappa variable 4-92 Neighboring gene immunoglobulin kappa chain variable 4-91 Neighboring gene immunoglobulin kappa chain variable 12-89 Neighboring gene immunoglobulin kappa chain variable 4-90 Neighboring gene STARR-seq mESC enhancer starr_16205 Neighboring gene immunoglobulin kappa variable 13-87 Neighboring gene immunoglobulin kappa chain variable 1-88 Neighboring gene immunoglobulin kappa chain variable 13-80-1 Neighboring gene immunoglobulin kappa chain variable 13-85 Neighboring gene STARR-seq mESC enhancer starr_16206 Neighboring gene immunoglobulin kappa chain variable 13-84 Neighboring gene immunoglobulin kappa variable 4-86 Neighboring gene immunoglobulin kappa variable 13-78-1 Neighboring gene predicted gene, 53190 Neighboring gene immunoglobulin kappa chain variable 13-82 Neighboring gene immunoglobulin kappa chain variable 4-83 Neighboring gene STARR-seq mESC enhancer starr_16207 Neighboring gene immunoglobulin kappa variable 4-81 Neighboring gene immunoglobulin kappa variable 4-80 Neighboring gene immunoglobulin kappa chain variable 13-74-1 Neighboring gene immunoglobulin kappa chain variable 13-73-1 Neighboring gene immunoglobulin kappa variable 4-79 Neighboring gene immunoglobulin kappa variable 4-78 Neighboring gene immunoglobulin kappa chain variable 13-76 Neighboring gene immunoglobulin kappa chain variable 13-71-1 Neighboring gene STARR-seq mESC enhancer starr_16209 Neighboring gene immunoglobulin kappa variable 4-77 Neighboring gene immunoglobulin kappa chain variable 4-75 Neighboring gene STARR-seq mESC enhancer starr_16210 Neighboring gene immunoglobulin kappa variable 4-74 Neighboring gene immunoglobulin kappa variable 4-73 Neighboring gene STARR-seq mESC enhancer starr_16212 Neighboring gene STARR-seq mESC enhancer starr_16211 Neighboring gene immunoglobulin kappa chain variable 4-72 Neighboring gene immunoglobulin kappa chain variable 4-71 Neighboring gene immunoglobulin kappa chain variable 13-62-1 Neighboring gene immunoglobulin kappa chain variable 4-70 Neighboring gene immunoglobulin kappa chain variable 13-61-1 Neighboring gene immunoglobulin kappa chain variable 12-67 Neighboring gene immunoglobulin kappa variable 4-69 Neighboring gene immunoglobulin kappa chain variable 12-66 Neighboring gene STARR-seq mESC enhancer starr_16214 Neighboring gene immunoglobulin kappa variable 4-68 Neighboring gene immunoglobulin kappa chain variable 13-64 Neighboring gene immunoglobulin kappa chain variable 4-65 Neighboring gene immunoglobulin kappa variable 4-63 Neighboring gene immunoglobulin kappa variable 13-57-2 Neighboring gene immunoglobulin kappa variable 4-62 Neighboring gene immunoglobulin kappa chain variable 4-61 Neighboring gene immunoglobulin kappa chain variable 13-57-1 Neighboring gene immunoglobulin kappa chain variable 13-56-1 Neighboring gene immunoglobulin kappa variable 4-59 Neighboring gene immunoglobulin kappa variable 4-57-1 Neighboring gene immunoglobulin kappa chain variable 13-55-1 Neighboring gene immunoglobulin kappa variable 4-60 Neighboring gene ribonuclease P RNA-like 1 Neighboring gene immunoglobulin kappa chain variable 13-54-1 Neighboring gene immunoglobulin kappa variable 4-58 Neighboring gene immunoglobulin kappa variable 4-57 Neighboring gene immunoglobulin kappa chain variable 4-56 Neighboring gene immunoglobulin kappa variable 4-55 Neighboring gene immunoglobulin kappa chain variable 4-54 Neighboring gene immunoglobulin kappa variable 4-53 Neighboring gene immunoglobulin kappa chain variable 12-49 Neighboring gene immunoglobulin kappa chain variable 4-51 Neighboring gene STARR-seq mESC enhancer starr_16217 Neighboring gene immunoglobulin kappa variable 4-50 Neighboring gene immunoglobulin kappa variable 12-47 Neighboring gene immunoglobulin kappa variable 12-46 Neighboring gene immunoglobulin kappa variable 5-48 Neighboring gene STARR-seq mESC enhancer starr_16218 Neighboring gene STARR-seq mESC enhancer starr_16219 Neighboring gene STARR-seq mESC enhancer starr_16220 Neighboring gene immunoglobulin kappa variable 12-44 Neighboring gene immunoglobulin kappa chain variable 5-40-1 Neighboring gene immunoglobulin kappa chain variable 5-45 Neighboring gene immunoglobulin kappa chain variable 12-42 Neighboring gene immunoglobulin kappa chain variable 12-41 Neighboring gene immunoglobulin kappa chain variable 5-43 Neighboring gene STARR-seq mESC enhancer starr_16221 Neighboring gene immunoglobulin kappa chain variable 12-40 Neighboring gene STARR-positive B cell enhancer ABC_E6435 Neighboring gene STARR-seq mESC enhancer starr_16222 Neighboring gene immunoglobulin kappa variable 5-39 Neighboring gene immunoglobulin kappa chain variable 12-38 Neighboring gene STARR-seq mESC enhancer starr_16224 Neighboring gene STARR-seq mESC enhancer starr_16226 Neighboring gene STARR-seq mESC enhancer starr_16225 Neighboring gene immunoglobulin kappa chain variable 18-36 Neighboring gene STARR-seq mESC enhancer starr_16227 Neighboring gene STARR-seq mESC enhancer starr_16228 Neighboring gene immunoglobulin kappa variable 5-37 Neighboring gene STARR-seq mESC enhancer starr_16229 Neighboring gene STARR-seq mESC enhancer starr_16230 Neighboring gene immunoglobulin kappa variable 1-35 Neighboring gene immunoglobulin kappa variable 8-34 Neighboring gene immunoglobulin kappa chain variable 7-33 Neighboring gene immunoglobulin kappa variable 6-32 Neighboring gene immunoglobulin kappa chain variable 8-31 Neighboring gene immunoglobulin kappa chain variable 8-30 Neighboring gene STARR-seq mESC enhancer starr_16231 Neighboring gene immunoglobulin kappa chain variable 6-29 Neighboring gene immunoglobulin kappa variable 8-28 Neighboring gene immunoglobulin kappa variable 8-23-1 Neighboring gene immunoglobulin kappa chain variable 8-27 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 2 Neighboring gene immunoglobulin kappa variable 8-26 Neighboring gene STARR-seq mESC enhancer starr_16232 Neighboring gene immunoglobulin kappa chain variable 6-25 Neighboring gene immunoglobulin kappa chain variable 8-24 Neighboring gene immunoglobulin kappa variable 6-23 Neighboring gene predicted gene, 46962 Neighboring gene immunoglobulin kappa chain variable 8-22 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 8-21 Neighboring gene immunoglobulin kappa variable 6-20 Neighboring gene STARR-seq mESC enhancer starr_16234 Neighboring gene immunoglobulin kappa variable 8-19 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 8-18 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_16235 Neighboring gene immunoglobulin kappa variable 6-17 Neighboring gene immunoglobulin kappa variable 8-16 Neighboring gene immunoglobulin kappa variable 6-15 Neighboring gene immunoglobulin kappa chain variable 3-12-1 Neighboring gene immunoglobulin kappa variable 6-14 Neighboring gene immunoglobulin kappa variable 6-13 Neighboring gene STARR-seq mESC enhancer starr_16236 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 pseudogene Neighboring gene immunoglobulin kappa variable 3-12 Neighboring gene STARR-positive B cell enhancer ABC_E6436 Neighboring gene STARR-seq mESC enhancer starr_16238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70712736-70712889 Neighboring gene STARR-positive B cell enhancer mm9_chr6:70702533-70702834 Neighboring gene STARR-positive B cell enhancer mm9_chr6:70694043-70694344 Neighboring gene STARR-positive B cell enhancer ABC_E2193 Neighboring gene STARR-positive B cell enhancer ABC_E11318 Neighboring gene STARR-positive B cell enhancer ABC_E11317 Neighboring gene STARR-positive B cell enhancer ABC_E9273 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 3-11 Neighboring gene immunoglobulin kappa variable 3-10 Neighboring gene immunoglobulin kappa variable 3-9 Neighboring gene immunoglobulin kappa variable 3-8 Neighboring gene immunoglobulin kappa variable 3-7 Neighboring gene immunoglobulin kappa variable 3-6 Neighboring gene immunoglobulin kappa chain variable 3-5 Neighboring gene immunoglobulin kappa variable 3-4 Neighboring gene immunoglobulin kappa variable 3-3 Neighboring gene immunoglobulin kappa variable 3-2 Neighboring gene immunoglobulin kappa variable 3-1 Neighboring gene predicted gene, 30211 Neighboring gene predicted gene, 57753 Neighboring gene predicted gene, 46961 Neighboring gene immunoglobulin kappa joining 4 Neighboring gene immunoglobulin kappa joining 5 Neighboring gene immunoglobulin kappa joining 3 Neighboring gene immunoglobulin kappa joining 2 Neighboring gene immunoglobulin kappa joining 1 Neighboring gene immunoglobulin kappa constant Neighboring gene ribose 5-phosphate isomerase A

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • kappa light chain variable region

Clone Names

  • MGC6612, MGC28604, MGC41421, MGC102615, MGC150007

General protein information

Names
immunoglobulin kappa chain complex
kappa light chain variable region

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005612.1 

    Range
    656..3171774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    67532620..70703738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013763.1: Suppressed sequence

    Description
    NM_001013763.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.