U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sspo SCO-spondin [ Mus musculus (house mouse) ]

Gene ID: 243369, updated on 5-Mar-2024

Summary

Official Symbol
Sspoprovided by MGI
Official Full Name
SCO-spondinprovided by MGI
Primary source
MGI:MGI:2674311
See related
Ensembl:ENSMUSG00000029797 AllianceGenome:MGI:2674311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scospondin
Summary
Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell differentiation and nervous system development. Predicted to act upstream of or within cell adhesion. Located in cytoplasm. Is expressed in several structures, including central nervous system. Orthologous to human SSPOP (SCO-spondin, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 4.1), colon adult (RPKM 1.4) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
6 B2.3; 6 23.42 cM
Exon count:
106
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48423164..48478196)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48446230..48501262)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38803 Neighboring gene predicted gene, 57777 Neighboring gene zinc finger protein 467 Neighboring gene STARR-positive B cell enhancer mm9_chr6:48394046-48394347 Neighboring gene zinc finger protein 862, pseudogene Neighboring gene ribosomal protein L35a pseudogene Neighboring gene PEST proteolytic signal containing nuclear protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
SCO-spondin
Names
subcommissural organ spondin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173428.4NP_775604.3  SCO-spondin precursor

    Status: VALIDATED

    Source sequence(s)
    AC153815
    Consensus CDS
    CCDS57420.1
    UniProtKB/TrEMBL
    A0A1D5RLZ9, E9Q0I4
    Related
    ENSMUSP00000131401.3, ENSMUST00000169350.9
    Conserved Domains (14) summary
    smart00192
    Location:14951526
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25392591
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29282975
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:556716
    VWD; von Willebrand factor (vWF) type D domain
    smart00231
    Location:20702225
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    smart00832
    Location:754826
    C8; This domain contains 8 conserved cysteine residues
    cd00057
    Location:21052225
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00112
    Location:14191453
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:15661602
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28152863
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10171166
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:472527
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12041274
    C8; C8 domain
    cl17735
    Location:49805035
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48423164..48478196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506069.4XP_006506132.1  SCO-spondin isoform X5

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:14951526
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25282580
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29172964
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:556716
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:754826
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14191453
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:49715026
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21052225
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:15661602
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28042852
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10171164
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:472527
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12081274
    C8; C8 domain
  2. XM_017321577.1XP_017177066.1  SCO-spondin isoform X5

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:14951526
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25282580
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29172964
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:556716
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:754826
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14191453
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:49715026
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21052225
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:15661602
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28042852
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10171164
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:472527
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12081274
    C8; C8 domain
  3. XM_036166109.1XP_036022002.1  SCO-spondin isoform X16

    Conserved Domains (14) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:20072063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00094
    Location:10541203
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12441311
    C8; C8 domain
    pfam19028
    Location:25082559
    TSP1_spondin; Spondin-like TSP1 domain
    cd19941
    Location:866919
    TIL; trypsin inhibitor-like cysteine rich domain
  4. XM_017321581.2XP_017177070.1  SCO-spondin isoform X14

    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:20072063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam03154
    Location:23132423
    Atrophin-1; Atrophin-1 family
    pfam08742
    Location:12451311
    C8; C8 domain
  5. XM_017321582.2XP_017177071.1  SCO-spondin isoform X15

    Conserved Domains (14) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:20072063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam03154
    Location:23132423
    Atrophin-1; Atrophin-1 family
    pfam08742
    Location:12451311
    C8; C8 domain
  6. XM_036166108.1XP_036022001.1  SCO-spondin isoform X11

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (15) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:48824937
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541203
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12441311
    C8; C8 domain
    pfam19028
    Location:34123458
    TSP1_spondin; Spondin-like TSP1 domain
    cd19941
    Location:866919
    TIL; trypsin inhibitor-like cysteine rich domain
  7. XM_017321574.3XP_017177063.1  SCO-spondin isoform X1

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:50085063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12451311
    C8; C8 domain
  8. XM_006506068.5XP_006506131.1  SCO-spondin isoform X3

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Related
    ENSMUSP00000148570.2, ENSMUST00000212740.2
    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:50085063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12451311
    C8; C8 domain
  9. XM_017321580.3XP_017177069.1  SCO-spondin isoform X9

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:50085063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12451311
    C8; C8 domain
  10. XM_017321575.3XP_017177064.1  SCO-spondin isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:50085063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12451311
    C8; C8 domain
  11. XM_030255369.2XP_030111229.1  SCO-spondin isoform X10

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:50085063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12451311
    C8; C8 domain
  12. XM_017321578.2XP_017177067.1  SCO-spondin isoform X6

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:49695024
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12451311
    C8; C8 domain
  13. XM_030255368.2XP_030111228.1  SCO-spondin isoform X7

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:49695024
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12451311
    C8; C8 domain
  14. XM_017321579.3XP_017177068.1  SCO-spondin isoform X8

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (14) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25172569
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29062953
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:49605015
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:27932841
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam03154
    Location:23132424
    Atrophin-1; Atrophin-1 family
    pfam08742
    Location:12451311
    C8; C8 domain
  15. XM_017321576.2XP_017177065.1  SCO-spondin isoform X4

    UniProtKB/TrEMBL
    A0A1D5RLZ9
    Conserved Domains (13) summary
    smart00192
    Location:15321563
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:25652617
    TSP1; Thrombospondin type 1 repeats
    smart00215
    Location:29543001
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:593753
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:791863
    C8; This domain contains 8 conserved cysteine residues
    cd00112
    Location:14561490
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:50085063
    VWC; von Willebrand factor type C domain
    cl25480
    Location:21422262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:16031639
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:28412889
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:10541201
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:509564
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12451311
    C8; C8 domain
  16. XM_006506070.3XP_006506133.1  SCO-spondin isoform X12

    UniProtKB/Swiss-Prot
    E9QMN0, Q8CG65
    Conserved Domains (10) summary
    smart00192
    Location:667698
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:17001752
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:591625
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:20892136
    VWC; von Willebrand factor type C domain
    cl25480
    Location:12771397
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:738774
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:19762024
    TSP_1; Thrombospondin type 1 domain
    pfam00094
    Location:189336
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:450506
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:380446
    C8; C8 domain
  17. XM_006506071.1XP_006506134.1  SCO-spondin isoform X13

    UniProtKB/Swiss-Prot
    E9QMN0, Q8CG65
    Conserved Domains (10) summary
    smart00192
    Location:470501
    LDLa; Low-density lipoprotein receptor domain class A
    smart00209
    Location:15031555
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:394428
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl17735
    Location:18921939
    VWC; von Willebrand factor type C domain
    cl25480
    Location:10801200
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00057
    Location:541577
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00090
    Location:17791827
    TSP_1; Thrombospondin type 1 domain
    pfam01826
    Location:253309
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:183249
    C8; C8 domain
    cl02516
    Location:60139
    VWD; von Willebrand factor type D domain

RNA

  1. XR_001785128.3 RNA Sequence

  2. XR_003956195.2 RNA Sequence