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Eno2 enolase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24334, updated on 5-Sep-2021

Summary

Symbol
Eno2provided by RGD
Full Name
enolase 2provided by RGD
Primary source
RGD:2554
See related
Ensembl:ENSRNOG00000013141 Ensembl:ENSRNOG00000048365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NSE; RNEN3
Summary
catalyzes the interconversion of 2-phosphoglycerate to phosphoenolpyruvate; may play a role in glycolysis [RGD, Feb 2006]
Annotation information
Note: LOC100911625 appears to be a duplicate placement of Eno2 (GeneID: 24334) on Rnor_6.0 (Annot. Release 105) that is absent from Rn_Celera and is not supported by syntenic regions in mouse and human. BLAST analysis of the underlying component AABR07066868.1 against the rat genome shows high sequence identity (88% coverage, 99% identity) with part of NC_005103.4 on which Eno2 is annotated. Annotation of Eno2 at this location on Rnor_6.0 is supported by annotation on Rn_Celera and synteny with mouse and human. [14 Apr 2021]
Expression
Biased expression in Brain (RPKM 1706.0) and Uterus (RPKM 89.6) See more
Orthologs
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Genomic context

See Eno2 in Genome Data Viewer
Location:
4q42
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157572085..157580971, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157285192..157294090, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene gene rich cluster, C10 gene Neighboring gene uncharacterized LOC102549865 Neighboring gene atrophin 1 Neighboring gene uncharacterized LOC120102384 Neighboring gene leucine rich repeat containing 23 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphopyruvate hydratase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in multicellular organismal reproductive process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphopyruvate hydratase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
gamma-enolase
Names
2-phospho-D-glycerate hydro-lyase
enolase 2, gamma, neuronal
gamma-enolase-like
neural enolase
neuron-specific enolase
NP_647541.1
XP_006237392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139325.4NP_647541.1  gamma-enolase

    See identical proteins and their annotated locations for NP_647541.1

    Status: VALIDATED

    Source sequence(s)
    CB615520, JACYVU010000150
    UniProtKB/Swiss-Prot
    P07323
    Related
    ENSRNOP00000005601.3, ENSRNOT00000005601.4
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    157572085..157580971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237330.4XP_006237392.1  gamma-enolase isoform X1

    See identical proteins and their annotated locations for XP_006237392.1

    UniProtKB/Swiss-Prot
    P07323
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
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