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Eno2 enolase 2, gamma, neuronal [ Rattus norvegicus (Norway rat) ]

Gene ID: 24334, updated on 29-Apr-2018
Official Symbol
Eno2provided by RGD
Official Full Name
enolase 2, gamma, neuronalprovided by RGD
Primary source
RGD:2554
See related
Ensembl:ENSRNOG00000013141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NSE; RNEN3
Summary
catalyzes the interconversion of 2-phosphoglycerate to phosphoenolpyruvate; may play a role in glycolysis [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 1706.0) and Uterus (RPKM 89.6) See more
Orthologs
See Eno2 in Genome Data Viewer
Location:
4q42
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157285192..157294090, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (224302788..224311673, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene gene rich cluster, C10 gene Neighboring gene uncharacterized LOC102553919 Neighboring gene atrophin 1 Neighboring gene leucine rich repeat containing 23 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphopyruvate hydratase activity TAS
Traceable Author Statement
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
canonical glycolysis IDA
Inferred from Direct Assay
more info
PubMed 
gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organismal reproductive process IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell cortex region IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
phosphopyruvate hydratase complex IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
gamma-enolase
Names
2-phospho-D-glycerate hydro-lyase
neural enolase
neuron-specific enolase
NP_647541.1
XP_006237392.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139325.4NP_647541.1  gamma-enolase

    See identical proteins and their annotated locations for NP_647541.1

    Status: VALIDATED

    Source sequence(s)
    AC129138, CB615520
    UniProtKB/Swiss-Prot
    P07323
    Related
    ENSRNOP00000005601.3, ENSRNOT00000005601.4
    Conserved Domains (2) summary
    PLN00191
    Location:2432
    PLN00191; enolase
    cd03313
    Location:5416
    enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    157285192..157294090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237330.3XP_006237392.1  gamma-enolase isoform X1

    See identical proteins and their annotated locations for XP_006237392.1

    UniProtKB/Swiss-Prot
    P07323
    Conserved Domains (2) summary
    PLN00191
    Location:2432
    PLN00191; enolase
    cd03313
    Location:5416
    enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    146310173..146318990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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