U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc29a4 solute carrier family 29 (nucleoside transporters), member 4 [ Mus musculus (house mouse) ]

Gene ID: 243328, updated on 9-Mar-2023

Summary

Official Symbol
Slc29a4provided by MGI
Official Full Name
solute carrier family 29 (nucleoside transporters), member 4provided by MGI
Primary source
MGI:MGI:2385330
See related
Ensembl:ENSMUSG00000050822 AllianceGenome:MGI:2385330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ENT4; mPMAT
Summary
Enables several functions, including monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including monoamine transport; toxin transport; and xenobiotic transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in brain and male reproductive gland or organ. Orthologous to human SLC29A4 (solute carrier family 29 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 34.0), CNS E14 (RPKM 29.0) and 11 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Slc29a4 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142678124..142708245)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142692478..142722490)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31274 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene predicted gene, 40352 Neighboring gene trinucleotide repeat containing 18 Neighboring gene predicted gene, 31365 Neighboring gene predicted gene 15770

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC38048

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in adenosine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenosine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in epinephrine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in epinephrine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in monoamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in organic acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in organic cation transport ISO
Inferred from Sequence Orthology
more info
 
involved_in serotonin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in serotonin uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonin uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
equilibrative nucleoside transporter 4
Names
solute carrier family 29 member 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146257.2NP_666369.1  equilibrative nucleoside transporter 4

    See identical proteins and their annotated locations for NP_666369.1

    Status: VALIDATED

    Source sequence(s)
    BC025599, BY727407
    Consensus CDS
    CCDS39364.1
    UniProtKB/Swiss-Prot
    Q8R139
    Related
    ENSMUSP00000059896.8, ENSMUST00000058418.8
    Conserved Domains (1) summary
    cl15430
    Location:75498
    Nucleoside_tran; Nucleoside transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142678124..142708245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504706.4XP_006504769.1  equilibrative nucleoside transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_006504769.1

    UniProtKB/Swiss-Prot
    Q8R139
    Conserved Domains (1) summary
    cl15430
    Location:75498
    Nucleoside_tran; Nucleoside transporter
  2. XM_036165132.1XP_036021025.1  equilibrative nucleoside transporter 4 isoform X2

    Conserved Domains (1) summary
    cl15430
    Location:29343
    Nucleoside_tran; Nucleoside transporter
  3. XM_006504707.4XP_006504770.1  equilibrative nucleoside transporter 4 isoform X2

    Conserved Domains (1) summary
    cl15430
    Location:29343
    Nucleoside_tran; Nucleoside transporter