Edn2 endothelin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Edn2provided by RGD
Official Full Name: endothelin 2provided by RGD
Primary source: RGD:2533
See related: Ensembl:ENSRNOG00000009390 AllianceGenome:RGD:2533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Et2; VIC; ET-2; PPET2; RNEDN2S01
Summary: Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in several processes, including ovarian follicle rupture; phospholipase C-activating G protein-coupled receptor signaling pathway; and regulation of hormone secretion. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human EDN2 (endothelin 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Muscle (RPKM 1.2), Heart (RPKM 0.8) and 6 other tissues See more
Orthologs: all
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Genomic context

Location:: 5q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (139036576..139042074)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (133751316..133756814)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The HIF-1a-mediated ET-2 signaling pathway may be an important mechanism regulating polycystic ovary syndrome formation and treatment in mammalian ovaries.
Title: Expression and clinical significance of the HIF-1a/ET-2 signaling pathway during the development and treatment of polycystic ovary syndrome.
Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries.
Title: Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries.
HIF-1alpha-induced transcriptional activation may be one of the important mechanisms mediating the increase of ET-2 expression in granulosa cells during the gonadotropin-induced mammalian ovulatory process.
Title: Regulatory effect of hypoxia-inducible factor-1α on hCG-stimulated endothelin-2 expression in granulosa cells from the PMSG-treated rat ovary.
HIF-1alpha-mediated ET-2 transcriptional activation is one of the important mechanisms regulating gonadotropin-induced mammalian ovulatory precess in vivo.
Title: Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins.
ET-1 and ET-2 cause long-lasting arterial contractions with comparable sensitivities and maximal responses
Title: Endothelin-1 and -2: two amino acids matter.
endothelin peptide is produced before ovulation and the contractile action of endothelin-2 within the ovary is facilitated via endothelin receptor A in rats
Title: Production and binding of endothelin-2 (EDN2) in the rat ovary: endothelin receptor subtype A (EDNRA)-mediated contraction.
EDN2 induces follicular rupture by constricting periovulatory follicles.
Title: Endothelin-2 in ovarian follicle rupture.
expression of ET-2/VIC and ET-1 mediated by reactive oxygen species may be associated with neuronal differentiation through the regulation of IL-6
Title: Cobalt chloride induces neurite outgrowth in rat pheochromocytoma PC-12 cells through regulation of endothelin-2/vasoactive intestinal contractor.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142434 (e-PCR)
- UniSTS:231681

D5Rat55 (e-PCR)
- UniSTS:118923

d5mit19 (e-PCR)
- UniSTS:120462

d5rat86 (e-PCR)
- UniSTS:120474

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endothelin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin B receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in axon extension	ISO Inferred from Sequence Orthology more info
involved_in cell tip growth	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle rupture	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by endothelin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by endothelin	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within temperature homeostasis	ISO Inferred from Sequence Orthology more info
involved_in vasculature development	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vein smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vein smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelin-2

Names: Endothelin isopeptide 2; preproendothelin-2; vasoactive intestinal contractor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012549.3 → NP_036681.2 endothelin-2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P23943

UniProtKB/TrEMBL

G3V771

Related

ENSRNOP00000012569.1, ENSRNOT00000012569.5

Conserved Domains (2) summary

smart00272
Location:93 → 113

END; Endothelin

pfam00322
Location:43 → 70

Endothelin; Endothelin family