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Edn1 endothelin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24323, updated on 27-Nov-2024

Summary

Official Symbol
Edn1provided by RGD
Official Full Name
endothelin 1provided by RGD
Primary source
RGD:2532
See related
EnsemblRapid:ENSRNOG00000014361 AllianceGenome:RGD:2532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Et1
Summary
Enables endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of secretion by cell; and response to corticosteroid. Located in several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 116.5), Uterus (RPKM 28.1) and 6 other tissues See more
Orthologs
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Genomic context

See Edn1 in Genome Data Viewer
Location:
17p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (22660799..22666687, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (22454924..22460812, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (22136814..22143745, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482770 Neighboring gene uncharacterized LOC120097835 Neighboring gene Jupiter microtubule associated 1, pseudogene 2 Neighboring gene uncharacterized LOC102548003 Neighboring gene HIVEP zinc finger 1 Neighboring gene uncharacterized LOC120097876

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables endothelin A receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endothelin A receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endothelin A receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables endothelin B receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endothelin B receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endothelin B receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in artery smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in artery smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in axonogenesis involved in innervation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within body fluid secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP/PKA signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to human chorionic gonadotropin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to luteinizing hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mineralocorticoid stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to type II interferon IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endothelin receptor signaling pathway involved in heart process ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial fluid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerular endothelium development ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart process ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maternal process involved in parturition IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in meiotic cell cycle process involved in oocyte maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within middle ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in neural crest cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neural crest cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide transport ISO
Inferred from Sequence Orthology
more info
 
involved_in noradrenergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipase D-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in podocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of odontogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of prostaglandin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of prostaglandin-endoperoxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sarcomere organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C deactivation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of D-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of pH ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of systemic arterial blood pressure by endothelin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of systemic arterial blood pressure by endothelin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
involved_in renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to amphetamine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to leptin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to muscle stretch IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ozone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to prostaglandin F IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to salt IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to transforming growth factor beta IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within rhythmic excitation ISO
Inferred from Sequence Orthology
more info
 
involved_in semaphorin-plexin signaling pathway involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sympathetic neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in vein smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vein smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Weibel-Palade body IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endothelin-1
Names
ET-1
PPET1
preproendothelin-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012548.2NP_036680.1  endothelin-1 preproprotein

    See identical proteins and their annotated locations for NP_036680.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    P22388
    UniProtKB/TrEMBL
    A6J756
    Related
    ENSRNOP00000019361.1, ENSRNOT00000019361.4
    Conserved Domains (2) summary
    smart00272
    Location:109130
    END; Endothelin
    pfam00322
    Location:4977
    Endothelin; Endothelin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    22660799..22666687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)