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Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 [ Mus musculus (house mouse) ]

Gene ID: 243168, updated on 13-Nov-2022

Summary

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Official Symbol
Hsd17b13provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 13provided by MGI
Primary source
MGI:MGI:2140804
See related
Ensembl:ENSMUSG00000034528 AllianceGenome:MGI:2140804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pan1b; PAN1B-like
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Predicted to act upstream of or within positive regulation of lipid biosynthetic process. Located in lipid droplet. Orthologous to human HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 99.4) and liver adult (RPKM 46.5) See more
Orthologs
human all
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Genomic context

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See Hsd17b13 in Genome Data Viewer
Location:
5; 5 E5
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104103308..104125254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (103955442..103977388, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene kelch-like 8 Neighboring gene predicted gene, 42139 Neighboring gene predicted gene, 24897 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11 Neighboring gene microRNA 5619 Neighboring gene nudix hydrolase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice. Su W, et al. Nat Commun, 2022 Nov 2. PMID 36323699, Free PMC Article
  2. Hydroxysteroid (17β) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice. Adam M, et al. FASEB J, 2018 Jun. PMID 29401633
  3. Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. Su W, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25028495, Free PMC Article
  4. 17beta-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein. Horiguchi Y, et al. Biochem Biophys Res Commun, 2008 May 30. PMID 18359291
  5. A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse. Isaacs AM, et al. J Neurosci, 2003 Mar 1. PMID 12629167, Free PMC Article

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of 17beta-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice.
    Title: Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice.
  2. data indicate that disruption of Hsd17b13 impairs hepatic-lipid metabolism in mice, resulting in liver steatosis and inflammation, but the enzyme does not play a major role in the regulation of reproductive functions.
    Title: Hydroxysteroid (17β) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice.
  3. 17beta-HSD13 as a pathogenic protein in the development of nonalcoholic fatty liver disease.
    Title: Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.
  4. 17betaHSD type 13 may have a distinct physiological role as a lipid droplet-associated protein in the liver.
    Title: 17beta-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
17-beta-hydroxysteroid dehydrogenase 13
Names
17-beta-HSD 13
short-chain dehydrogenase/reductase 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163486.1 → NP_001156958.1  17-beta-hydroxysteroid dehydrogenase 13 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001156958.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (2).
    Source sequence(s)
    AI048624, AI573700, DV660487
    Consensus CDS
    CCDS51576.1
    UniProtKB/Swiss-Prot
    Q8VCR2
    Related
    ENSMUSP00000108422.3, ENSMUST00000112803.3
    Conserved Domains (2) summary
    cd05339
    Location:38 → 277
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    pfam00106
    Location:37 → 228
    adh_short; short chain dehydrogenase

  2. NM_198030.2 → NP_932147.2  17-beta-hydroxysteroid dehydrogenase 13 isoform 2 precursor

    See identical proteins and their annotated locations for NP_932147.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at its 3' terminus, compared to variant 1, which results in a protein (isoform 2) with a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI048624, AI573700, AL714024, DV660487
    Consensus CDS
    CCDS19480.1
    UniProtKB/Swiss-Prot
    Q8CIU2, Q8VCR2
    Related
    ENSMUSP00000046772.9, ENSMUST00000048118.15
    Conserved Domains (2) summary
    cd05339
    Location:38 → 269
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    pfam00106
    Location:37 → 228
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    104103308..104125254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCR2.2 GenPept UniProtKB/Swiss-Prot:Q8VCR2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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