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Nqo1 NAD(P)H quinone dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24314, updated on 30-Jun-2018
Official Symbol
Nqo1provided by RGD
Official Full Name
NAD(P)H quinone dehydrogenase 1provided by RGD
Primary source
RGD:2503
See related
Ensembl:ENSRNOG00000012772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dia4
Summary
enzyme that acts as an antioxidant; involved in increasing neuronal damage after injury [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 195.1), Liver (RPKM 132.4) and 9 other tissues See more
Orthologs
See Nqo1 in Genome Data Viewer
Location:
19q12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38422210..38437103)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (49291903..49306856)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene NEDD4-like E3 ubiquitin-protein ligase WWP2 Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene nuclear factor of activated T-cells 5 Neighboring gene zinc finger protein 90

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC93075

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD(P)H dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD(P)H dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
 
electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide dismutase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hydrogen sulfide IEP
Inferred from Expression Pattern
more info
PubMed 
response to nitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
NAD(P)H dehydrogenase [quinone] 1
Names
DT-diaphorase
DTD
Diaphorase (NADH/NADPH)
NAD(P)H dehydrogenase, quinone 1
NAD(P)H:menadione oxidoreductase
NAD(P)H:quinone oxidoreductase 1
QR1
azoreductase
menadione reductase
phylloquinone reductase
quinone reductase 1
NP_058696.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017000.3NP_058696.2  NAD(P)H dehydrogenase [quinone] 1

    See identical proteins and their annotated locations for NP_058696.2

    Status: VALIDATED

    Source sequence(s)
    BC083542
    UniProtKB/Swiss-Prot
    P05982
    Related
    ENSRNOP00000017175.4, ENSRNOT00000017174.5
    Conserved Domains (1) summary
    pfam02525
    Location:5212
    Flavodoxin_2; Flavodoxin-like fold

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    38422210..38437103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    34717059..34731947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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