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Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24303, updated on 27-Nov-2024

Summary

Official Symbol
Cyp2d3provided by RGD
Official Full Name
cytochrome P450, family 2, subfamily d, polypeptide 3provided by RGD
Primary source
RGD:2472
See related
EnsemblRapid:ENSRNOG00000080638 AllianceGenome:RGD:2472
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp2d6; Cyp2d13
Summary
Enables monooxygenase activity. Involved in liver development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 1691.9) See more
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Genomic context

See Cyp2d3 in Genome Data Viewer
Location:
7q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115797785..115802142, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113917711..113922068, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123634400..123638757, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 5 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 1 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 2 Neighboring gene transcription factor 20 Neighboring gene uncharacterized LOC134479801

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Clone Names

  • MGC108561

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cytochrome P450 2D3
Names
CYPIID3
Cytochrome P450, subfamily IID3
P450-DB3
cytochrome P450, family 2, subfamily d, polypeptide 13
cytochrome P450, family 2, subfamily d, polypeptide 6
cytochrome P450-DB3
debrisoquine 4-hydroxylase
NP_775116.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173093.1NP_775116.1  cytochrome P450 2D3

    See identical proteins and their annotated locations for NP_775116.1

    Status: PROVISIONAL

    Source sequence(s)
    AB008424
    UniProtKB/Swiss-Prot
    O35106, P12938, Q5FVU3
    UniProtKB/TrEMBL
    A0A8L2QP93, A6HT75
    Related
    ENSRNOP00000048711.6, ENSRNOT00000044470.7
    Conserved Domains (1) summary
    pfam00067
    Location:37496
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115797785..115802142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)