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Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24300, updated on 30-Sep-2021

Summary

Symbol
Cyp2b1provided by RGD
Full Name
cytochrome P450, family 2, subfamily b, polypeptide 1provided by RGD
Primary source
RGD:2466
See related
EnsemblRapid:ENSRNOG00000063855
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cypbe; Cyp2b-1
Summary
phenobarbitol-inducible member of the p450 xenobiotic-inducible superfamily involved in hydroxylation of decanoic and other fatty acids [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 886.2) and Liver (RPKM 326.0) See more
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Genomic context

See Cyp2b1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (81518387..81544999)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (99142431..99183540)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096896 Neighboring gene Cyp2s1 protein-like Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 2 Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC188065

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp70 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables steroid hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to sulfur dioxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in xenobiotic catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 2B1
Names
CYPIIB1
Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e)
P450-B
P450-LM2
P450-PB1 and P450-PB2
P450b
cytochrome P450-B
cytochrome P450-LM2
cytochrome P450-PB1
cytochrome P450-PB2
cytochrome P450b
NP_001128316.1
XP_038950984.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134844.1NP_001128316.1  cytochrome P450 2B1 precursor

    See identical proteins and their annotated locations for NP_001128316.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166502
    UniProtKB/TrEMBL
    B2GV28
    Related
    ENSRNOP00000045196.5, ENSRNOT00000047540.6
    Conserved Domains (1) summary
    pfam00067
    Location:48488
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    81518387..81544999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095056.1XP_038950984.1  cytochrome P450 2B1 isoform X1

    Conserved Domains (1) summary
    cd20672
    Location:88512
    CYP2B; cytochrome P450 family 2, subfamily B
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