Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp1a2provided by RGD
Official Full Name: cytochrome P450, family 1, subfamily a, polypeptide 2provided by RGD
Primary source: RGD:2459
See related: Ensembl:ENSRNOG00000016173 AllianceGenome:RGD:2459
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CYPD45; P-450d; RATCYPD45
Summary: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including cellular response to copper ion; response to estradiol; and response to lipopolysaccharide. Located in intracellular membrane-bounded organelle. Biomarker of mental depression. Human ortholog(s) of this gene implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda. Orthologous to human CYP1A2 (cytochrome P450 family 1 subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1573.8) See more
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Genomic context

Location:: 8q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58075367..58082255, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (62451360..62458244, complement)

Chromosome 8 - NC_051343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-kappaB-mediated signaling pathway in vitro and in vivo.
Title: Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-κB-mediated signaling pathway in vitro and in vivo.
findings provide evidences that miR-320 might inhibit the development of Steroid-induced avascular necrosis of femoral head by targeting CYP1A2.
Title: Upregulation of microRNA-320 decreases the risk of developing steroid-induced avascular necrosis of femoral head by inhibiting CYP1A2 both in vivo and in vitro.
acute Formaldehyde (FA) poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats. And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways.
Title: The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats.
Blast-induced traumatic brain injury has a significant impact on the expression of CYP1A2 in liver.
Title: Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats.
CYP1A2 activity was reduced in rats after acute exposure to high altitude of 4300m and metronidazole.
Title: The effects of metronidazole on Cytochrome P450 Activity and Expression in rats after acute exposure to high altitude of 4300m.
drugs acting as D2-dopamine receptor antagonists can modify several hormone systems that regulate the expression of CYP1A1, CYP1A2 and CYP1B1, and may affect the toxicity and carcinogenicity outcome of numerous toxicants and pre-carcinogenic substances
Title: Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver.
Intragastric administration of suberoylanilide hydroxamic acid inhibited CYP1A2 activity.
Title: Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities.
As for CYP1A2 and CYP3A4, the negligible inhibitions were observed.
Title: Inhibitory effects of cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots.
Incense smoke exposure significantly induced the expression of CYP1A1, CYP1A2, and CYP1B1 mRNAs in both lung and liver tissues.
Title: Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke.
Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs
Title: Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Arb11 (e-PCR)
- UniSTS:240428

PMC291882P1 (e-PCR)
- UniSTS:272440

D8Wox5 (e-PCR)
- UniSTS:239944

RH141189 (e-PCR)
- UniSTS:223185

d8mgh13 (e-PCR)
- UniSTS:120529

D8Wox33 (e-PCR)
- UniSTS:518880

Homology

Homologs of the Cyp1a2 gene: The Cyp1a2 gene is conserved in human, chimpanzee, dog, cow, mouse, A.thaliana, and rice.
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables caffeine oxidase activity	ISO Inferred from Sequence Orthology more info
enables demethylase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 2-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alkaloid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular aromatic compound metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular respiration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dibenzo-p-dioxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterocycle metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hydrogen peroxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in monocarboxylic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoterpenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxidative demethylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within porphyrin-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in toxin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 1A2

Names: CYPIA2; Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); P-448; P450-D; cholesterol 25-hydroxylase; cytochrome P-448; cytochrome P-450d; cytochrome P450, 1a2; cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450-D; hydroperoxy icosatetraenoate dehydratase

NP_036673.3

EC 1.14.14.1

EC 4.2.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.