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Fbxl5 F-box and leucine-rich repeat protein 5 [ Mus musculus (house mouse) ]

Gene ID: 242960, updated on 6-Jun-2024

Summary

Official Symbol
Fbxl5provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 5provided by MGI
Primary source
MGI:MGI:2152883
See related
Ensembl:ENSMUSG00000039753 AllianceGenome:MGI:2152883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbl4; Fir4
Summary
Predicted to enable iron ion binding activity. Acts upstream of or within iron ion homeostasis and positive regulation of cellular protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human FBXL5 (F-box and leucine rich repeat protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 17.0), placenta adult (RPKM 16.2) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxl5 in Genome Data Viewer
Location:
5 B3; 5 23.81 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (43901958..43939529, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43744618..43782149, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related protein 7 Neighboring gene STARR-seq mESC enhancer starr_12973 Neighboring gene predicted gene 15866 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene predicted gene, 35762 Neighboring gene STARR-seq mESC enhancer starr_12974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:44215949-44216168 Neighboring gene STARR-positive B cell enhancer ABC_E8052 Neighboring gene STARR-seq mESC enhancer starr_12977 Neighboring gene STARR-seq mESC enhancer starr_12978 Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene predicted gene, 54296

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159963.2NP_001153435.1  F-box/LRR-repeat protein 5 isoform A

    See identical proteins and their annotated locations for NP_001153435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AC140277
    Consensus CDS
    CCDS51489.1
    UniProtKB/Swiss-Prot
    Q14CG1, Q3TAK6, Q3TWC9, Q3UC66, Q80XI5, Q8BGF5, Q8BNL3, Q8C2S5, Q8C3Q8
    UniProtKB/TrEMBL
    F7BZC4
    Related
    ENSMUSP00000045792.10, ENSMUST00000047857.16
    Conserved Domains (4) summary
    cd09293
    Location:340404
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:358384
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:205249
    F-box-like; F-box-like
  2. NM_001424600.1NP_001411529.1  F-box/LRR-repeat protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  3. NM_001424602.1NP_001411531.1  F-box/LRR-repeat protein 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  4. NM_001424604.1NP_001411533.1  F-box/LRR-repeat protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
    Related
    ENSMUSP00000143703.2, ENSMUST00000196483.5
  5. NM_001424605.1NP_001411534.1  F-box/LRR-repeat protein 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  6. NM_001424606.1NP_001411535.1  F-box/LRR-repeat protein 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  7. NM_001424607.1NP_001411536.1  F-box/LRR-repeat protein 5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
    Related
    ENSMUSP00000109681.4, ENSMUST00000114047.10
  8. NM_001424608.1NP_001411537.1  F-box/LRR-repeat protein 5 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    D3Z584, F7BZC4
    Related
    ENSMUSP00000113557.2, ENSMUST00000119523.8
  9. NM_001424609.1NP_001411538.1  F-box/LRR-repeat protein 5 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  10. NM_001424610.1NP_001411539.1  F-box/LRR-repeat protein 5 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  11. NM_001424611.1NP_001411540.1  F-box/LRR-repeat protein 5 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  12. NM_001424612.1NP_001411541.1  F-box/LRR-repeat protein 5 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  13. NM_001424613.1NP_001411542.1  F-box/LRR-repeat protein 5 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  14. NM_001424614.1NP_001411543.1  F-box/LRR-repeat protein 5 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC140277
    UniProtKB/TrEMBL
    F7BZC4
  15. NM_001424615.1NP_001411544.1  F-box/LRR-repeat protein 5 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC140277
  16. NM_001424616.1NP_001411545.1  F-box/LRR-repeat protein 5 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC140277
  17. NM_001424617.1NP_001411546.1  F-box/LRR-repeat protein 5 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC140277
  18. NM_001424618.1NP_001411547.1  F-box/LRR-repeat protein 5 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC140277
  19. NM_178729.5NP_848844.1  F-box/LRR-repeat protein 5 isoform B

    See identical proteins and their annotated locations for NP_848844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 3' terminus, compared to variant 1, which results in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC140277
    Consensus CDS
    CCDS19263.1
    UniProtKB/TrEMBL
    F7BZC4
    Related
    ENSMUSP00000084733.5, ENSMUST00000087465.11
    Conserved Domains (4) summary
    cd09293
    Location:340404
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:333357
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:205249
    F-box-like; F-box-like

RNA

  1. NR_188801.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140277
  2. NR_188802.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140277
  3. NR_188803.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140277

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    43901958..43939529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165123.1XP_036021016.1  F-box/LRR-repeat protein 5 isoform X1

    UniProtKB/TrEMBL
    F7BZC4
    Conserved Domains (4) summary
    cd09293
    Location:340404
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:358384
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:205249
    F-box-like

RNA

  1. XR_004942514.1 RNA Sequence