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Fbxl5 F-box and leucine-rich repeat protein 5 [ Mus musculus (house mouse) ]

Gene ID: 242960, updated on 5-Jan-2023

Summary

Official Symbol
Fbxl5provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 5provided by MGI
Primary source
MGI:MGI:2152883
See related
Ensembl:ENSMUSG00000039753 AllianceGenome:MGI:2152883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbl4; Fir4
Summary
Predicted to enable iron ion binding activity. Acts upstream of or within iron ion homeostasis and positive regulation of cellular protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human FBXL5 (F-box and leucine rich repeat protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 17.0), placenta adult (RPKM 16.2) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxl5 in Genome Data Viewer
Location:
5; 5 B3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (43901958..43939529, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43744618..43782149, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related protein 7 Neighboring gene predicted gene 15866 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene predicted gene, 35762 Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene predicted gene, 54296

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159963.1NP_001153435.1  F-box/LRR-repeat protein 5 isoform A

    See identical proteins and their annotated locations for NP_001153435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AK150664, AK159744, BY245949
    Consensus CDS
    CCDS51489.1
    UniProtKB/Swiss-Prot
    Q8C2S5, Q8C3Q8
    Related
    ENSMUSP00000045792.10, ENSMUST00000047857.16
    Conserved Domains (4) summary
    cd09293
    Location:340404
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:358384
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:205249
    F-box-like; F-box-like
  2. NM_178729.4NP_848844.1  F-box/LRR-repeat protein 5 isoform B

    See identical proteins and their annotated locations for NP_848844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 3' terminus, compared to variant 1, which results in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK041497, BC113798, BY245949
    Consensus CDS
    CCDS19263.1
    UniProtKB/Swiss-Prot
    Q8C2S5
    Related
    ENSMUSP00000084733.5, ENSMUST00000087465.11
    Conserved Domains (4) summary
    cd09293
    Location:340404
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:333357
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:205249
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    43901958..43939529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165123.1XP_036021016.1  F-box/LRR-repeat protein 5 isoform X1

    Conserved Domains (4) summary
    cd09293
    Location:340404
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:358384
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:205249
    F-box-like

RNA

  1. XR_004942514.1 RNA Sequence