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Cryaa crystallin, alpha A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24273, updated on 27-Nov-2024

Summary

Official Symbol
Cryaaprovided by RGD
Official Full Name
crystallin, alpha Aprovided by RGD
Primary source
RGD:2413
See related
EnsemblRapid:ENSRNOG00000047175 AllianceGenome:RGD:2413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Crya1; Acry-1
Summary
This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in Spleen (RPKM 26.6) and Thymus (RPKM 5.1) See more
Orthologs
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Genomic context

See Cryaa in Genome Data Viewer
Location:
20p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9784872..9788656)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9783605..9787351)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10438444..10442189)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene cystathionine beta synthase Neighboring gene U2 small nuclear RNA auxiliary factor 1 Neighboring gene uncharacterized LOC103694395 Neighboring gene uncharacterized LOC134483882

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of eye lens TAS
Traceable Author Statement
more info
PubMed 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lens development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lens fiber cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lens morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intracellular transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to UV-A ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within tubulin complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-crystallin A chain
Names
Crystallin, alpha polypeptide A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289737.2NP_001276666.1  alpha-crystallin A chain isoform 2

    See identical proteins and their annotated locations for NP_001276666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as alpha Ains-crystallin) is longer, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    P24623
    UniProtKB/TrEMBL
    A6JK11
    Conserved Domains (2) summary
    pfam00525
    Location:151
    Crystallin; Alpha crystallin A chain, N terminal
    cl00175
    Location:86168
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  2. NM_012534.5NP_036666.2  alpha-crystallin A chain isoform 1

    See identical proteins and their annotated locations for NP_036666.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0JN13
    Related
    ENSRNOP00000108761.1, ENSRNOT00000150532.1
    Conserved Domains (2) summary
    cd06497
    Location:60145
    ACD_alphaA-crystallin_HspB4; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaA-crystallin (HspB4, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:151
    Crystallin; Alpha crystallin A chain, N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    9784872..9788656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278950.1XP_063135020.1  alpha-crystallin A chain isoform X1

    Related
    ENSRNOP00000112676.1, ENSRNOT00000071248.4