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Wasf2 WAS protein family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 242687, updated on 12-Aug-2019

Summary

Official Symbol
Wasf2provided by MGI
Official Full Name
WAS protein family, member 2provided by MGI
Primary source
MGI:MGI:1098641
See related
Ensembl:ENSMUSG00000028868
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WAVE2; AW742646; D4Ertd13e
Expression
Ubiquitous expression in thymus adult (RPKM 47.2), lung adult (RPKM 40.4) and 28 other tissues See more
Orthologs

Genomic context

See Wasf2 in Genome Data Viewer
Location:
4 D2.3; 4 66.22 cM
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133130531..133199748)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (132686548..132754245)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 26615 Neighboring gene nuclear encoded tRNA glycine 1 (anticodon GCC) Neighboring gene microRNA 7017 Neighboring gene G-protein coupled receptor 3 Neighboring gene CD164 sialomucin-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament-based movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
ameboidal-type cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
movement of cell or subcellular component IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
SCAR complex ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ISO
Inferred from Sequence Orthology
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
synapse EXP
Inferred from Experiment
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
wiskott-Aldrich syndrome protein family member 2
Names
WASP family protein member 2
protein WAVE-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153423.6NP_700472.1  wiskott-Aldrich syndrome protein family member 2

    See identical proteins and their annotated locations for NP_700472.1

    Status: PROVISIONAL

    Source sequence(s)
    AL671858
    Consensus CDS
    CCDS18742.1
    UniProtKB/Swiss-Prot
    Q8BH43
    Related
    ENSMUSP00000081263.5, ENSMUST00000084241.11
    Conserved Domains (1) summary
    pfam02205
    Location:433459
    WH2; WH2 motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p6 C57BL/6J

    Range
    133130531..133199748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538849.4XP_006538912.1  wiskott-Aldrich syndrome protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_006538912.1

    UniProtKB/Swiss-Prot
    Q8BH43
    Conserved Domains (1) summary
    pfam02205
    Location:433459
    WH2; WH2 motif
  2. XM_006538850.4XP_006538913.1  wiskott-Aldrich syndrome protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_006538913.1

    UniProtKB/Swiss-Prot
    Q8BH43
    Conserved Domains (1) summary
    pfam02205
    Location:433459
    WH2; WH2 motif
  3. XM_006538848.4XP_006538911.1  wiskott-Aldrich syndrome protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_006538911.1

    UniProtKB/Swiss-Prot
    Q8BH43
    Conserved Domains (1) summary
    pfam02205
    Location:433459
    WH2; WH2 motif
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