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Cp ceruloplasmin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24268, updated on 18-Aug-2021

Summary

Official Symbol
Cpprovided by RGD
Official Full Name
ceruloplasminprovided by RGD
Primary source
RGD:2387
See related
Ensembl:ENSRNOG00000011913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CERP
Summary
copper-containing ferroxidase that promotes iron incorporation into transferrin; plays a role in iron metabolism and homeostatis [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 6726.9), Spleen (RPKM 532.4) and 2 other tissues See more
Orthologs
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Genomic context

Location:
2q24
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102439433..102498075)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104744249..104803034)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial pseudogene Neighboring gene similar to homolog of yeast ribosome biogenesis regulatory protein RRS1 Neighboring gene HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene helicase-like transcription factor Neighboring gene glycogenin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding TAS
Traceable Author Statement
more info
PubMed 
enables ferroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables ferroxidase activity TAS
Traceable Author Statement
more info
PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular iron ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lactation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in lung development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mammary gland involution IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in plasma membrane copper ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in response to copper ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ceruloplasmin
Names
bilitranslocase
ceruloplasmin (ferroxidase)
NP_001257890.1
NP_036664.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270961.1NP_001257890.1  ceruloplasmin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains two alternate 3' exons compared to variant 1. The resulting protein (isoform 2), which is longer and has a distinct C-terminus compared to isoform 1, is a glycosylphosphatidylinositol-anchored form.
    Source sequence(s)
    JACYVU010000067
    UniProtKB/TrEMBL
    A0A0G2K9I6
    Related
    ENSRNOP00000075010.1, ENSRNOT00000082627.1
    Conserved Domains (5) summary
    cd04225
    Location:726896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11012
    Location:9071051
    CuRO_6_ceruloplasmin; The sixth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:369566
    Cupredoxin; Cupredoxin superfamily
  2. NM_012532.2NP_036664.2  ceruloplasmin isoform 1 precursor

    See identical proteins and their annotated locations for NP_036664.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes a secreted protein (isoform 1).
    Source sequence(s)
    JACYVU010000067
    UniProtKB/TrEMBL
    G3V7K3
    Related
    ENSRNOP00000016083.4, ENSRNOT00000016083.5
    Conserved Domains (5) summary
    cd04225
    Location:726896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11012
    Location:9071051
    CuRO_6_ceruloplasmin; The sixth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:369566
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    102439433..102498075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_590972.3 RNA Sequence

  2. XR_005500237.1 RNA Sequence

  3. XR_005500236.1 RNA Sequence

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