U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Azin2 antizyme inhibitor 2 [ Mus musculus (house mouse) ]

Gene ID: 242669, updated on 26-Sep-2022

Summary

Official Symbol
Azin2provided by MGI
Official Full Name
antizyme inhibitor 2provided by MGI
Primary source
MGI:MGI:2442093
See related
Ensembl:ENSMUSG00000028789 AllianceGenome:MGI:2442093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adc; Azi2; Odcp; ODC-p; B930082O19; 4933429I20Rik
Summary
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Expression
Biased expression in testis adult (RPKM 55.5), lung adult (RPKM 9.7) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Azin2 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128824026..128856250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128930233..128962456, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene, 33901 Neighboring gene predicted gene 15904 Neighboring gene adenylate kinase 2 Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene ring finger protein 19B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables arginine decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables ornithine decarboxylase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ornithine decarboxylase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ornithine decarboxylase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables ornithine decarboxylase activator activity ISO
Inferred from Sequence Orthology
more info
 
NOT enables ornithine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables ornithine decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in granular vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
NOT located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
antizyme inhibitor 2
Names
ODC antizyme inhibitor-2
ODC-like protein
arginine decarboxylase
ornithine decarboxylase paralog
ornithine decarboxylase-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301841.1NP_001288770.1  antizyme inhibitor 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the 5' coding region (which results in translation initiation from an in-frame downstream AUG) and contains a novel 3' terminal exon compared to variant 1. The resulting isoform (2) is shorter with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC065772, CJ183131
    Consensus CDS
    CCDS80159.1
    UniProtKB/TrEMBL
    A8Y5E7, Q6P078
    Related
    ENSMUSP00000114086.2, ENSMUST00000119354.8
    Conserved Domains (1) summary
    cd00622
    Location:1312
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
  2. NM_172875.4NP_766463.1  antizyme inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_766463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK077201, AL607086, BB398156, CJ183131
    Consensus CDS
    CCDS18678.1
    UniProtKB/Swiss-Prot
    A2A823, Q8BVM4
    UniProtKB/TrEMBL
    B2RSR5
    Related
    ENSMUSP00000030581.4, ENSMUST00000030581.10
    Conserved Domains (1) summary
    cd00622
    Location:40407
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    128824026..128856250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503106.5XP_006503169.1  antizyme inhibitor 2 isoform X1

    Conserved Domains (1) summary
    cd00622
    Location:33349
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
  2. XM_011240538.4XP_011238840.1  antizyme inhibitor 2 isoform X4

    Conserved Domains (1) summary
    cd00622
    Location:1312
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
  3. XM_006503108.5XP_006503171.1  antizyme inhibitor 2 isoform X3

    Conserved Domains (1) summary
    cd00622
    Location:4318
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
  4. XM_006503107.4XP_006503170.1  antizyme inhibitor 2 isoform X2

    Conserved Domains (1) summary
    cd00622
    Location:40350
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

RNA

  1. XR_004941899.1 RNA Sequence

  2. XR_001784145.3 RNA Sequence