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Dmrta2 doublesex and mab-3 related transcription factor like family A2 [ Mus musculus (house mouse) ]

Gene ID: 242620, updated on 12-May-2024

Summary

Official Symbol
Dmrta2provided by MGI
Official Full Name
doublesex and mab-3 related transcription factor like family A2provided by MGI
Primary source
MGI:MGI:2653629
See related
Ensembl:ENSMUSG00000047143 AllianceGenome:MGI:2653629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dmrt5
Summary
Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within nervous system development and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human DMRTA2 (DMRT like family A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 8.1), CNS E14 (RPKM 5.1) and 9 other tissues See more
Orthologs
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Genomic context

See Dmrta2 in Genome Data Viewer
Location:
4 C7; 4 51.37 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109835222..109840896)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109977989..109983691)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 2C Neighboring gene Fas-associated factor 1 Neighboring gene STARR-seq mESC enhancer starr_11075 Neighboring gene STARR-seq mESC enhancer starr_11076 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_11077 Neighboring gene STARR-seq mESC enhancer starr_11078 Neighboring gene predicted gene, 33070 Neighboring gene ELAV like RNA binding protein 4 Neighboring gene predicted gene, 54251

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
doublesex- and mab-3-related transcription factor A2
Names
doublesex- and mab-3-related transcription factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172296.2NP_758500.2  doublesex- and mab-3-related transcription factor A2

    See identical proteins and their annotated locations for NP_758500.2

    Status: VALIDATED

    Source sequence(s)
    AI465212, AL627188, AY145837, CJ172393
    Consensus CDS
    CCDS18469.1
    UniProtKB/Swiss-Prot
    A2A9A2, Q8CFF8
    Related
    ENSMUSP00000060441.4, ENSMUST00000061187.4
    Conserved Domains (2) summary
    cd14418
    Location:308349
    CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
    pfam00751
    Location:65111
    DM; DM DNA binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    109835222..109840896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503093.5XP_006503156.1  doublesex- and mab-3-related transcription factor A2 isoform X1

    See identical proteins and their annotated locations for XP_006503156.1

    UniProtKB/Swiss-Prot
    A2A9A2, Q8CFF8
    Conserved Domains (2) summary
    cd14418
    Location:308349
    CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
    pfam00751
    Location:65111
    DM; DM DNA binding domain
  2. XM_006503094.5XP_006503157.1  doublesex- and mab-3-related transcription factor A2 isoform X1

    See identical proteins and their annotated locations for XP_006503157.1

    UniProtKB/Swiss-Prot
    A2A9A2, Q8CFF8
    Conserved Domains (2) summary
    cd14418
    Location:308349
    CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
    pfam00751
    Location:65111
    DM; DM DNA binding domain