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Cftr CF transmembrane conductance regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 24255, updated on 12-Jan-2022

Summary

Official Symbol
Cftrprovided by RGD
Official Full Name
CF transmembrane conductance regulatorprovided by RGD
Primary source
RGD:2332
See related
Ensembl:ENSRNOG00000055103
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561193
Summary
Predicted to enable several functions, including PDZ domain binding activity; Sec61 translocon complex binding activity; and anion transmembrane transporter activity. Involved in several processes, including animal organ development; anion transport; and regulation of cell development. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and microvillus. Colocalizes with early endosome. Used to study congenital bilateral absence of vas deferens; cystic fibrosis; dental enamel hypoplasia; duodenal ulcer; and gastric ulcer. Biomarker of autosomal recessive polycystic kidney disease; cholestasis; and salpingitis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Testes (RPKM 31.8), Lung (RPKM 28.8) and 5 other tissues See more
Orthologs
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Genomic context

See Cftr in Genome Data Viewer
Location:
4q21
Exon count:
28
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (46561269..46728759)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (42693263..42860679)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 2 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene cortactin binding protein 2 Neighboring gene uncharacterized LOC120102241

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables Sec61 translocon complex binding IEA
Inferred from Electronic Annotation
more info
 
enables Sec61 translocon complex binding ISO
Inferred from Sequence Orthology
more info
 
enables bicarbonate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables bicarbonate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables bicarbonate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chloride channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables chloride channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride channel inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chloride transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly ATP-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables intracellularly ATP-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly ATP-gated chloride channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in amelogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in amelogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in bicarbonate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in bicarbonate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to anoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to forskolin IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to forskolin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in enamel mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular pH elevation IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular pH elevation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular pH elevation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane hyperpolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane hyperpolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in multicellular organismal water homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organismal water homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organismal water homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cyclic nucleotide-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cyclic nucleotide-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of enamel mineralization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of enamel mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of Sertoli cell barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of voltage-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amiloride IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm capacitation IEA
Inferred from Electronic Annotation
more info
 
involved_in sperm capacitation ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transepithelial chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transepithelial water transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transepithelial water transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial water transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle docking involved in exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in water transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cystic fibrosis transmembrane conductance regulator
Names
ATP-binding cassette sub-family C member 7
ATP-binding cassette transporter sub-family C member 7
cAMP-dependent chloride channel
channel conductance-controlling ATPase
cystic fibrosis transmembrane conductance regulator homolog
NP_113694.1
XP_006236159.1
XP_038962934.1
XP_038962935.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031506.1NP_113694.1  cystic fibrosis transmembrane conductance regulator

    See identical proteins and their annotated locations for NP_113694.1

    Status: PROVISIONAL

    Source sequence(s)
    DP000027
    UniProtKB/Swiss-Prot
    P34158
    Related
    ENSRNOP00000094868.1, ENSRNOT00000113457.1
    Conserved Domains (1) summary
    TIGR01271
    Location:11464
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    46561269..46728759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107006.1XP_038962934.1  cystic fibrosis transmembrane conductance regulator isoform X2

    Conserved Domains (1) summary
    TIGR01271
    Location:551483
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
  2. XM_006236097.4XP_006236159.1  cystic fibrosis transmembrane conductance regulator isoform X1

    Related
    ENSRNOP00000072565.1, ENSRNOT00000085043.2
    Conserved Domains (6) summary
    cd03291
    Location:444724
    ABCC_CFTR1; ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C
    TIGR01271
    Location:551518
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:9151196
    ABC_membrane; ABC transporter transmembrane region
    pfam14396
    Location:693898
    CFTR_R; Cystic fibrosis TM conductance regulator (CFTR), regulator domain
    cl00549
    Location:139357
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:12581518
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_039107007.1XP_038962935.1  cystic fibrosis transmembrane conductance regulator isoform X3

    Conserved Domains (1) summary
    TIGR01271
    Location:11464
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
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