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Cat catalase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24248, updated on 27-Nov-2024

Summary

Official Symbol
Catprovided by RGD
Official Full Name
catalaseprovided by RGD
Primary source
RGD:2279
See related
EnsemblRapid:ENSRNOG00000008364 AllianceGenome:RGD:2279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CS1; Cas1; Catl; Cs-1; Cat01
Summary
Enables catalase activity. Involved in several processes, including hydrogen peroxide catabolic process; response to L-ascorbic acid; and response to vitamin E. Located in extracellular space and peroxisomal matrix. Used to study brain ischemia; cholestasis; colitis; and lung disease (multiple). Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); auditory system disease (multiple); eye disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 3517.9), Kidney (RPKM 1744.6) and 6 other tissues See more
Orthologs
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Genomic context

See Cat in Genome Data Viewer
Location:
3q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (110297340..110329526, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (89842393..89874577, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (93379872..93412058, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ets homologous factor Neighboring gene uncharacterized LOC102548892 Neighboring gene E74 like ETS transcription factor 5 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC120101609 Neighboring gene ribosomal protein S10, pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables aminoacylase activity ISO
Inferred from Sequence Orthology
more info
 
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
enables catalase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables catalase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables catalase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalase activity TAS
Traceable Author Statement
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on peroxide as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in UV protection ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular detoxification of hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemoglobin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to UV IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to amitrole IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to auditory stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to inactivity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to light intensity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ozone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to phenylpropanoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of catalase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012520.2NP_036652.1  catalase

    See identical proteins and their annotated locations for NP_036652.1

    Status: VALIDATED

    Source sequence(s)
    BC081853, FM043772
    UniProtKB/Swiss-Prot
    P04762
    UniProtKB/TrEMBL
    A6HNR6
    Related
    ENSRNOP00000011230.4, ENSRNOT00000011230.7
    Conserved Domains (1) summary
    cd08156
    Location:68497
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    110297340..110329526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)