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Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 242425, updated on 6-Oct-2024

Summary

Official Symbol
Gabbr2provided by MGI
Official Full Name
gamma-aminobutyric acid type B receptor subunit 2provided by MGI
Primary source
MGI:MGI:2386030
See related
Ensembl:ENSMUSG00000039809 AllianceGenome:MGI:2386030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gb2; Gm425; Gpr51; GABABR2
Summary
Predicted to enable G protein-coupled GABA receptor activity and protein heterodimerization activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway and neuron-glial cell signaling. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in cytoplasm and neuron projection. Is expressed in brain; lens; lens epithelium; lens fiber; and lens vesicle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 59 and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 32.0), cerebellum adult (RPKM 28.0) and 5 other tissues See more
Orthologs
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Genomic context

See Gabbr2 in Genome Data Viewer
Location:
4 B1; 4 25.18 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46662318..46991714, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46662318..46991714, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31850 Neighboring gene TBC1 domain family, member 2 Neighboring gene predicted gene, 42281 Neighboring gene STARR-seq mESC enhancer starr_10135 Neighboring gene predicted gene, 32208 Neighboring gene predicted gene, 32135 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47002653-47002836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47023500-47023609 Neighboring gene STARR-seq mESC enhancer starr_10138 Neighboring gene STARR-positive B cell enhancer mm9_chr4:47033511-47033812 Neighboring gene predicted gene 568 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled GABA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled GABA receptor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to G protein-coupled GABA receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled GABA receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron-glial cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, GABAergic NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of G protein-coupled GABA receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of G protein-coupled receptor heterodimeric complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of G protein-coupled receptor heterodimeric complex ISO
Inferred from Sequence Orthology
more info
 
part_of G protein-coupled receptor heterodimeric complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of GABA receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-aminobutyric acid type B receptor subunit 2
Names
gamma-aminobutyric acid (GABA) B receptor, 2
ortholog of human G protein-coupled receptor 51 GPR51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081141.2NP_001074610.1  gamma-aminobutyric acid type B receptor subunit 2 precursor

    See identical proteins and their annotated locations for NP_001074610.1

    Status: VALIDATED

    Source sequence(s)
    AL772399, AL831741, AL844224, BX005247, BX571848
    Consensus CDS
    CCDS38758.1
    UniProtKB/Swiss-Prot
    A2AL05, Q80T41
    Related
    ENSMUSP00000103378.3, ENSMUST00000107749.4
    Conserved Domains (4) summary
    PRK03992
    Location:785863
    PRK03992; proteasome-activating nucleotidase; Provisional
    cd15294
    Location:479748
    7tmC_GABA-B-R2; gamma-aminobutyric acid type B receptor subunit 2, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam18455
    Location:778816
    GBR2_CC; Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain
    cd06366
    Location:57459
    PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46662318..46991714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)