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Calm1 calmodulin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24242, updated on 12-Aug-2018

Summary

Official Symbol
Calm1provided by RGD
Official Full Name
calmodulin 1provided by RGD
Primary source
RGD:2257
See related
Ensembl:ENSRNOG00000004060
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CaMI; Calm; Cam1
Summary
may mediate calcium-dependent modulation of KCNQ channels; exists in two alternative splice forms [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 6512.2), Muscle (RPKM 2287.3) and 9 other tissues See more
Orthologs

Genomic context

See Calm1 in Genome Data Viewer
Location:
6q32
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124217241..124225292)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (133444207..133452258)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene protein app1-like Neighboring gene NRDE-2, necessary for RNA interference, domain containing Neighboring gene uncharacterized LOC108351372 Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene ribosomal protein S6 kinase A5 Neighboring gene similar to transmembrane protein 11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
N-terminal myristoylation domain binding IEA
Inferred from Electronic Annotation
more info
 
N-terminal myristoylation domain binding ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase activator activity IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase activator activity ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase binding IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
calcium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
calcium channel inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium channel regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion channel binding IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase binding IDA
Inferred from Direct Assay
more info
PubMed 
nitric-oxide synthase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
titin binding IEA
Inferred from Electronic Annotation
more info
 
titin binding ISO
Inferred from Sequence Orthology
more info
 
type 3 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of calcium ion IEA
Inferred from Electronic Annotation
more info
 
detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization to mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ryanodine-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation by host of symbiont cAMP-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation by host of symbiont cAMP-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
regulation of high voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
regulation of ryanodine-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of store-operated calcium channel activity IC
Inferred by Curator
more info
PubMed 
regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to amphetamine IEP
Inferred from Expression Pattern
more info
PubMed 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
spindle pole body organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
calcium channel complex IEA
Inferred from Electronic Annotation
more info
 
calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
catalytic complex IEA
Inferred from Electronic Annotation
more info
 
catalytic complex ISO
Inferred from Sequence Orthology
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
sarcomere IEA
Inferred from Electronic Annotation
more info
 
sarcomere ISO
Inferred from Sequence Orthology
more info
 
spindle microtubule IEA
Inferred from Electronic Annotation
more info
 
spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
spindle pole ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calmodulin-1
Names
Calmodulin 1 (phosphorylase kinase, delta)
caM
calmodulin I
NP_114175.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031969.2NP_114175.1  calmodulin-1

    See identical proteins and their annotated locations for NP_114175.1

    Status: PROVISIONAL

    Source sequence(s)
    X13933
    UniProtKB/Swiss-Prot
    P0DP29, P0DP30, P0DP31
    Related
    ENSRNOP00000063822.1, ENSRNOT00000064679.2
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    124217241..124225292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    117015915..117023918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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