Pm20d2 peptidase M20 domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pm20d2provided by MGI
Official Full Name: peptidase M20 domain containing 2provided by MGI
Primary source: MGI:MGI:2685270
See related: Ensembl:ENSMUSG00000054659 AllianceGenome:MGI:2685270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm424; Acy1l2
Summary: Enables dipeptidase activity. Acts upstream of or within proteolysis and regulation of cellular protein metabolic process. Predicted to be located in nucleoplasm. Orthologous to human PM20D2 (peptidase M20 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in heart adult (RPKM 11.4), adrenal adult (RPKM 9.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 A5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (33170401..33189737, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (33170401..33189737, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PM20D2 hydrolyzed beta-alanyl-lysine, beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and gamma-aminobutyryl-ornithine as its best substrates.
Title: Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase.

Submit: New GeneRIF Correction

General gene information

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Homology

Homologs of the Pm20d2 gene: The Pm20d2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 338 organisms have orthologs with human gene Pm20d2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
NOT enables para-aminobenzoyl-glutamate hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT involved_in folic acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
NOT is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: xaa-Arg dipeptidase; peptidase M20 domain-containing protein 2

Names: aminoacylase 1-like 2; aminoacylase-1-like protein 2

NP_001030039.2

EC 3.4.13.4

XP_006537963.1

EC 3.4.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034867.2 → NP_001030039.2 xaa-Arg dipeptidase

See identical proteins and their annotated locations for NP_001030039.2

Status: PROVISIONAL

Source sequence(s)

AL670464

Consensus CDS

CCDS51136.1

UniProtKB/Swiss-Prot

A3KG59, Q3ULU7

Related

ENSMUSP00000095783.3, ENSMUST00000098181.9

Conserved Domains (2) summary

cd05672
Location:30 → 401

M20_ACY1L2_like; M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily

COG1473
Location:34 → 389

AbgB; Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

33170401..33189737 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537900.1 → XP_006537963.1 peptidase M20 domain-containing protein 2 isoform X1

Conserved Domains (1) summary

cd05672
Location:30 → 447

M20_ACY1L2-like; M20 Peptidase aminoacylase 1-like protein 2-like, amidohydrolase subfamily