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C3 complement C3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24232, updated on 10-Jul-2024

Summary

Official Symbol
C3provided by RGD
Official Full Name
complement C3provided by RGD
Primary source
RGD:2232
See related
EnsemblRapid:ENSRNOG00000046834 AllianceGenome:RGD:2232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables lipid binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; response to estradiol; and response to steroid hormone. Located in extracellular space. Used to study glomerulonephritis; membranous glomerulonephritis; obesity; pneumonia; and pre-eclampsia. Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); pneumocystosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 17340.9) See more
Orthologs
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Genomic context

Location:
9q11
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (2174412..2201339, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (2087437..2114366, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9721137..9747084)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 14 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene G protein-coupled receptor 108 Neighboring gene thyroid hormone receptor interactor 10

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C5L2 anaphylatoxin chemotactic receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables C5L2 anaphylatoxin chemotactic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables C5L2 anaphylatoxin chemotactic receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in complement activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within complement activation ISO
Inferred from Sequence Orthology
more info
 
involved_in complement activation ISO
Inferred from Sequence Orthology
more info
 
involved_in complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in complement activation, classical pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in complement receptor mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in complement receptor mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within complement-dependent cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in complement-mediated synapse pruning IEA
Inferred from Electronic Annotation
more info
 
involved_in complement-mediated synapse pruning ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in oviduct epithelium development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within oviduct epithelium development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of activation of membrane attack complex IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of activation of membrane attack complex ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of developmental growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of lipid storage IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type IIa hypersensitivity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to magnesium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in tolerance induction IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in vertebrate eye-specific patterning IEA
Inferred from Electronic Annotation
more info
 
involved_in vertebrate eye-specific patterning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement C3
Names
complement component 3
NP_058690.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016994.2NP_058690.2  complement C3 precursor

    See identical proteins and their annotated locations for NP_058690.2

    Status: VALIDATED

    Source sequence(s)
    BI281644, CK366193, CO565011, CO569380, CO796620, CO800063, JAXUCZ010000009, X52477
    UniProtKB/Swiss-Prot
    P01026, Q9ET19, Q9QV57, Q9QV58
    UniProtKB/TrEMBL
    A6KQR3, M0RBJ7
    Related
    ENSRNOP00000066934.2, ENSRNOT00000075494.3
    Conserved Domains (10) summary
    cd00017
    Location:678747
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9961282
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cd03583
    Location:15131661
    NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
    pfam00207
    Location:770866
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129224
    A2M_N; MG2 domain
    pfam07677
    Location:13981493
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:455604
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:355445
    MG4; Macroglobulin domain MG4
    pfam17790
    Location:26124
    MG1; Macroglobulin domain MG1
    pfam17791
    Location:226307
    MG3; Macroglobulin domain MG3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    2174412..2201339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)