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C3 complement C3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24232, updated on 17-Nov-2020

Summary

Official Symbol
C3provided by RGD
Official Full Name
complement C3provided by RGD
Primary source
RGD:2232
See related
Ensembl:ENSRNOG00000046834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
putative complement component C3; likely involved in innate immune response [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 17340.9) See more
Orthologs

Genomic context

Location:
9q12
Exon count:
41
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9721137..9747084)
106 current Rn_Celera (GCF_000002265.2) 9 AC_000077.1 (6407133..6432968)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (8728465..8754412)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene G protein-coupled receptor 108 Neighboring gene TNF superfamily member 14 Neighboring gene Cd70 molecule

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
C5L2 anaphylatoxin chemotactic receptor binding IEA
Inferred from Electronic Annotation
more info
 
C5L2 anaphylatoxin chemotactic receptor binding ISO
Inferred from Sequence Orthology
more info
 
C5L2 anaphylatoxin chemotactic receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway involved in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway involved in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
complement activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement activation IDA
Inferred from Direct Assay
more info
PubMed 
complement activation ISO
Inferred from Sequence Orthology
more info
 
complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
complement activation, classical pathway TAS
Traceable Author Statement
more info
PubMed 
complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
complement-dependent cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
complement-mediated synapse pruning IEA
Inferred from Electronic Annotation
more info
 
complement-mediated synapse pruning ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
neuron remodeling IEA
Inferred from Electronic Annotation
more info
 
neuron remodeling ISO
Inferred from Sequence Orthology
more info
 
oviduct epithelium development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of activation of membrane attack complex IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activation of membrane attack complex ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of developmental growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of lipid storage IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type IIa hypersensitivity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type IIa hypersensitivity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
regulation of triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to bacterium ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to magnesium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to paclitaxel IEP
Inferred from Expression Pattern
more info
PubMed 
response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
tolerance induction IEP
Inferred from Expression Pattern
more info
PubMed 
vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
vertebrate eye-specific patterning IEA
Inferred from Electronic Annotation
more info
 
vertebrate eye-specific patterning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement C3
Names
complement component 3
NP_058690.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016994.2NP_058690.2  complement C3 precursor

    See identical proteins and their annotated locations for NP_058690.2

    Status: VALIDATED

    Source sequence(s)
    AABR07066499, BI281644, CK366193, CO565011, CO569380, CO796620, CO800063, X52477
    UniProtKB/Swiss-Prot
    P01026
    UniProtKB/TrEMBL
    M0RBF1
    Related
    ENSRNOP00000066885.1, ENSRNOT00000073042.3
    Conserved Domains (8) summary
    cd00017
    Location:678747
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9961282
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cd03583
    Location:15131661
    NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
    pfam00207
    Location:770866
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129224
    A2M_N; MG2 domain
    pfam07677
    Location:13981493
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10511282
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:457603
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    9721137..9747084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    6407133..6432968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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