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Dnai3 dynein axonemal intermediate chain 3 [ Mus musculus (house mouse) ]

Gene ID: 242253, updated on 8-Dec-2022

Summary

Official Symbol
Dnai3provided by MGI
Official Full Name
dynein axonemal intermediate chain 3provided by MGI
Primary source
MGI:MGI:3045269
See related
Ensembl:ENSMUSG00000043020 AllianceGenome:MGI:3045269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ida7; IC140; Wdr63; 4931433A13Rik
Summary
Predicted to enable Arp2/3 complex binding activity; dynein heavy chain binding activity; and dynein light chain binding activity. Involved in positive regulation of osteoblast differentiation. Part of axonemal dynein complex. Is expressed in choroid plexus; lung epithelium; node; and sensory organ. Orthologous to human DNAI3 (dynein axonemal intermediate chain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 12.4), lung adult (RPKM 1.2) and 1 other tissue See more
Orthologs
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Genomic context

See Dnai3 in Genome Data Viewer
Location:
3; 3 H2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145746281..145813855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146040526..146108100, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene synapse defective 1, Rho GTPase, homolog 2 (C. elegans) Neighboring gene predicted gene, 40166 Neighboring gene predicted gene, 35409 Neighboring gene mucolipin 3 Neighboring gene predicted gene, 25627 Neighboring gene mucolipin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of axonemal dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dynein axonemal intermediate chain 3; WD repeat-containing protein 63
Names
WD repeat domain 63
dynein intermediate chain 3, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172864.3NP_766452.2  dynein axonemal intermediate chain 3

    See identical proteins and their annotated locations for NP_766452.2

    Status: VALIDATED

    Source sequence(s)
    AK029903, BX631982
    Consensus CDS
    CCDS17899.2
    UniProtKB/Swiss-Prot
    B2RY71
    UniProtKB/TrEMBL
    B2RY71, Q8C0T4
    Related
    ENSMUSP00000124475.2, ENSMUST00000160285.2
    Conserved Domains (1) summary
    COG2319
    Location:384532
    WD40; WD40 repeat [General function prediction only]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145746281..145813855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319579.3XP_017175068.1  WD repeat-containing protein 63 isoform X1

    UniProtKB/TrEMBL
    Q8C0T4
    Conserved Domains (1) summary
    COG2319
    Location:198346
    WD40; WD40 repeat [General function prediction only]

RNA

  1. XR_867216.3 RNA Sequence