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Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24211, updated on 21-Jul-2020

Summary

Official Symbol
Atp1a1provided by RGD
Official Full Name
ATPase Na+/K+ transporting subunit alpha 1provided by RGD
Primary source
RGD:2167
See related
Ensembl:ENSRNOG00000030019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nkaa1b
Summary
mediates Na+ and K+ transport; may play a role in regulation of blood pressure [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Kidney (RPKM 7293.3), Heart (RPKM 1410.6) and 5 other tissues See more
Orthologs

Genomic context

See Atp1a1 in Genome Data Viewer
Location:
2q34
Exon count:
23
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (204003742..204032023, complement)
106 current Rn_Celera (GCF_000002265.2) 2 AC_000070.1 (181455492..181483650, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (223440514..223469880, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene immunoglobulin superfamily, member 3 Neighboring gene uncharacterized LOC103691652 Neighboring gene mab-21 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
potassium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion binding ISO
Inferred from Sequence Orthology
more info
 
sodium:potassium-exchanging ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sodium:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium:potassium-exchanging ATPase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to sodium:potassium-exchanging ATPase activity ISO
Inferred from Sequence Orthology
more info
 
steroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cardiac muscle contraction TAS
Traceable Author Statement
more info
PubMed 
cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
energy coupled proton transmembrane transport, against electrochemical gradient TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of transmembrane electrochemical gradient IC
Inferred by Curator
more info
PubMed 
membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucocorticoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
relaxation of cardiac muscle TAS
Traceable Author Statement
more info
PubMed 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to glycoside ISO
Inferred from Sequence Orthology
more info
 
NOT response to glycoside ISO
Inferred from Sequence Orthology
more info
 
sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
organelle membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
sodium:potassium-exchanging ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
sodium:potassium-exchanging ATPase complex ISO
Inferred from Sequence Orthology
more info
 
sperm flagellum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit alpha-1
Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATPase, Na+K+ transporting, alpha 1
Na(+)/K(+) ATPase alpha-1 subunit
sodium pump subunit alpha-1
NP_036636.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012504.1NP_036636.1  sodium/potassium-transporting ATPase subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_036636.1

    Status: VALIDATED

    Source sequence(s)
    M14511
    UniProtKB/Swiss-Prot
    P06685
    Related
    ENSRNOP00000045650.4, ENSRNOT00000040430.4
    Conserved Domains (6) summary
    smart00831
    Location:40114
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:606732
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:291023
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:134365
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:7991008
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:427521
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    204003742..204032023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    181455492..181483650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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