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Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24211, updated on 2-Jun-2019

Summary

Official Symbol
Atp1a1provided by RGD
Official Full Name
ATPase Na+/K+ transporting subunit alpha 1provided by RGD
Primary source
RGD:2167
See related
Ensembl:ENSRNOG00000030019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nkaa1b
Summary
mediates Na+ and K+ transport; may play a role in regulation of blood pressure [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Kidney (RPKM 7293.3), Heart (RPKM 1410.6) and 5 other tissues See more
Orthologs

Genomic context

See Atp1a1 in Genome Data Viewer
Location:
2q34
Exon count:
23
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (204003742..204032023, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (223440514..223469880, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene immunoglobulin superfamily, member 3 Neighboring gene uncharacterized LOC103691652 Neighboring gene mab-21 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Aldosterone-regulated sodium reabsorption, organism-specific biosystem (from KEGG)
    Aldosterone-regulated sodium reabsorption, organism-specific biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
  • Aldosterone-regulated sodium reabsorption, conserved biosystem (from KEGG)
    Aldosterone-regulated sodium reabsorption, conserved biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Carbohydrate digestion and absorption, organism-specific biosystem (from KEGG)
    Carbohydrate digestion and absorption, organism-specific biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
  • Carbohydrate digestion and absorption, conserved biosystem (from KEGG)
    Carbohydrate digestion and absorption, conserved biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Ion homeostasis, organism-specific biosystem (from REACTOME)
    Ion homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
    Ion transport by P-type ATPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mineral absorption, organism-specific biosystem (from KEGG)
    Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Mineral absorption, conserved biosystem (from KEGG)
    Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Proximal Tubule Transporters, organism-specific biosystem (from WikiPathways)
    Proximal Tubule Transporters, organism-specific biosystemThe proximal tubule of the nephron reabsorbs approximately two-thirds of the Na filtered through the glomerulus. Na extrusion from the cell by the basolateral Na/K-ATPase provides the gradient for ap...
  • Proximal tubule bicarbonate reclamation, organism-specific biosystem (from KEGG)
    Proximal tubule bicarbonate reclamation, organism-specific biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
  • Proximal tubule bicarbonate reclamation, conserved biosystem (from KEGG)
    Proximal tubule bicarbonate reclamation, conserved biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Thick Ascending Limb Transporters, organism-specific biosystem (from WikiPathways)
    Thick Ascending Limb Transporters, organism-specific biosystemThis pathway shows the main transporters in the thick ascending limb of the Loop of Henle
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Thyroid hormone synthesis, organism-specific biosystem (from KEGG)
    Thyroid hormone synthesis, organism-specific biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
  • Thyroid hormone synthesis, conserved biosystem (from KEGG)
    Thyroid hormone synthesis, conserved biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ATPase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylinositol 3-kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
potassium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
sodium:potassium-exchanging ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sodium:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium:potassium-exchanging ATPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
contributes_to sodium:potassium-exchanging ATPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
steroid hormone binding IEA
Inferred from Electronic Annotation
more info
 
steroid hormone binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle contraction TAS
Traceable Author Statement
more info
PubMed 
cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to steroid hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
energy coupled proton transmembrane transport, against electrochemical gradient TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of transmembrane electrochemical gradient IC
Inferred by Curator
more info
PubMed 
membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane repolarization IEA
Inferred from Electronic Annotation
more info
 
membrane repolarization ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of glucocorticoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glucocorticoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of striated muscle contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of striated muscle contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of the force of heart contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
relaxation of cardiac muscle TAS
Traceable Author Statement
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
PubMed 
response to glycoside IEA
Inferred from Electronic Annotation
more info
 
response to glycoside ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT response to glycoside ISO
Inferred from Sequence Orthology
more info
PubMed 
sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule ISO
Inferred from Sequence Orthology
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
PubMed 
sodium:potassium-exchanging ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
sodium:potassium-exchanging ATPase complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit alpha-1
Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATPase, Na+K+ transporting, alpha 1
Na(+)/K(+) ATPase alpha-1 subunit
sodium pump subunit alpha-1
NP_036636.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012504.1NP_036636.1  sodium/potassium-transporting ATPase subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_036636.1

    Status: VALIDATED

    Source sequence(s)
    M14511
    UniProtKB/Swiss-Prot
    P06685
    Related
    ENSRNOP00000045650.4, ENSRNOT00000040430.4
    Conserved Domains (6) summary
    smart00831
    Location:40114
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:606732
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:291023
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:134365
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:7991008
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:427521
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    204003742..204032023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    181455492..181483650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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