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Akr1b1 aldo-keto reductase family 1 member B [ Rattus norvegicus (Norway rat) ]

Gene ID: 24192, updated on 12-Jan-2022

Summary

Official Symbol
Akr1b1provided by RGD
Official Full Name
aldo-keto reductase family 1 member Bprovided by RGD
Primary source
RGD:2092
See related
Ensembl:ENSRNOG00000009513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Alr; Aldr1; ALDRED; Akr1b3; Akr1b4; ALR-P-I; RATALDRED
Summary
Enables alditol:NADP+ 1-oxidoreductase activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including inner medullary collecting duct development; positive regulation of receptor signaling pathway via JAK-STAT; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Heart (RPKM 1001.4), Adrenal (RPKM 795.8) and 9 other tissues See more
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Genomic context

See Akr1b1 in Genome Data Viewer
Location:
4q22
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (62932033..62946126, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (61706866..61720959, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member B4 Neighboring gene hypothetical protein LOC689277 Neighboring gene aldo-keto reductase family 1, member B8 Neighboring gene aldo-keto reductase family 1 member B10 Neighboring gene aldo-keto reductase family 1, member B7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-threo-aldose 1-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables NADP-retinol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alditol:NADP+ 1-oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alditol:NADP+ 1-oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables allyl-alcohol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glyceraldehyde oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycerol dehydrogenase [NADP+] activity IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin H2 endoperoxidase reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables retinal dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular hyperosmotic salinity response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 
involved_in cellular response to methylglyoxal IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in inner medullary collecting duct development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within metanephric collecting duct development ISO
Inferred from Sequence Orthology
more info
 
involved_in monosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic cyclic compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within renal water homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to thyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to water deprivation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in retinoid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sorbitol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress-activated protein kinase signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schwann cell microvillus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mast cell granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in paranodal junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane bounded cell projection cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aldo-keto reductase family 1 member B1
Names
AR
Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
aldose reductase
NP_036630.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012498.1NP_036630.1  aldo-keto reductase family 1 member B1

    See identical proteins and their annotated locations for NP_036630.1

    Status: PROVISIONAL

    Source sequence(s)
    M60322
    UniProtKB/Swiss-Prot
    P07943
    Related
    ENSRNOP00000012879.3, ENSRNOT00000012879.4
    Conserved Domains (2) summary
    COG0656
    Location:1297
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:8289
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    62932033..62946126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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