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Aldoc aldolase, fructose-bisphosphate C [ Rattus norvegicus (Norway rat) ]

Gene ID: 24191, updated on 12-Jan-2022

Summary

Official Symbol
Aldocprovided by RGD
Official Full Name
aldolase, fructose-bisphosphate Cprovided by RGD
Primary source
RGD:2091
See related
Ensembl:ENSRNOG00000011452
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ALDCAA; F16dip7; RATALDCAA
Summary
Enables fructose-bisphosphate aldolase activity and identical protein binding activity. Involved in several processes, including aging; animal organ regeneration; and response to hypoxia. Located in axon and cytoplasm. Is active in postsynaptic cytosol. Biomarker of borna disease and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward (RPKM 3215.1) See more
Orthologs
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Genomic context

See Aldoc in Genome Data Viewer
Location:
10q25
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63217477..63221066)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65586504..65590093)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene putative 60S ribosomal protein L37a-like Neighboring gene ribosomal protein S6 kinase related Neighboring gene sperm associated antigen 5 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class S Neighboring gene unc-119 lipid binding chaperone

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose-bisphosphate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fructose-bisphosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fructose-bisphosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
 
enables fructose-bisphosphate aldolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IDA
Inferred from Direct Assay
more info
PubMed 
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose 1,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fructose 1,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 1,6-bisphosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fructose-bisphosphate aldolase C
Names
aldolase C, fructose-biphosphate
aldolase C, fructose-bisphosphate
brain-type aldolase
NP_036629.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012497.1NP_036629.1  fructose-bisphosphate aldolase C

    See identical proteins and their annotated locations for NP_036629.1

    Status: PROVISIONAL

    Source sequence(s)
    M63656
    UniProtKB/Swiss-Prot
    P09117
    Related
    ENSRNOP00000015535.4, ENSRNOT00000015535.9
    Conserved Domains (1) summary
    pfam00274
    Location:15363
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    63217477..63221066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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