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Aldoa aldolase, fructose-bisphosphate A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24189, updated on 4-Nov-2022

Summary

Official Symbol
Aldoaprovided by RGD
Official Full Name
aldolase, fructose-bisphosphate Aprovided by RGD
Primary source
RGD:2089
See related
Ensembl:ENSRNOG00000052802 AllianceGenome:RGD:2089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aldo1; RNALDOG5
Summary
Predicted to enable several functions, including fructose binding activity; fructose-bisphosphate aldolase activity; and identical protein binding activity. Involved in several processes, including methylglyoxal biosynthetic process; response to estrogen; and response to lipopolysaccharide. Located in heterochromatin and mitochondrion. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 41307.8), Heart (RPKM 6179.8) and 2 other tissues See more
Orthologs
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Genomic context

See Aldoa in Genome Data Viewer
Location:
1q36
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181402275..181407476, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198228387..198233988, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene uncharacterized LOC103691235 Neighboring gene U6 spliceosomal RNA Neighboring gene TLC domain containing 3B Neighboring gene similar to human chromosome 16 open reading frame 92

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose-bisphosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fructose-bisphosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
 
enables fructose-bisphosphate aldolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical glycolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose 1,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in methylglyoxal biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in M band IEA
Inferred from Electronic Annotation
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sperm fibrous sheath ISO
Inferred from Sequence Orthology
more info
 
located_in sperm head ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fructose-bisphosphate aldolase A
Names
aldolase A, fructose-bisphosphate
muscle-type aldolase
NP_001170776.1
NP_001258465.1
NP_036627.1
XP_006230272.1
XP_038950008.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177305.1NP_001170776.1  fructose-bisphosphate aldolase A

    See identical proteins and their annotated locations for NP_001170776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    CO383722, CO398643, M14420
    UniProtKB/Swiss-Prot
    P05065, Q63038
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  2. NM_001271536.1NP_001258465.1  fructose-bisphosphate aldolase A

    See identical proteins and their annotated locations for NP_001258465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    CB750468, CF975930, FQ228954, FQ229100, JACYVU010000044
    UniProtKB/Swiss-Prot
    P05065, Q63038
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  3. NM_012495.2NP_036627.1  fructose-bisphosphate aldolase A

    See identical proteins and their annotated locations for NP_036627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    BC064440, CO383722, JACYVU010000044
    UniProtKB/Swiss-Prot
    P05065, Q63038
    Related
    ENSRNOP00000093578.1, ENSRNOT00000112001.1
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    181402275..181407476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230210.4XP_006230272.1  fructose-bisphosphate aldolase A isoform X1

    See identical proteins and their annotated locations for XP_006230272.1

    UniProtKB/TrEMBL
    A0A8L2R0P3
    Related
    ENSRNOP00000068764.2, ENSRNOT00000080988.2
    Conserved Domains (1) summary
    pfam00274
    Location:69418
    Glycolytic; Fructose-bisphosphate aldolase class-I
  2. XM_039094080.1XP_038950008.1  fructose-bisphosphate aldolase A isoform X1

    UniProtKB/TrEMBL
    A0A8L2R0P3
    Conserved Domains (1) summary
    pfam00274
    Location:69418
    Glycolytic; Fructose-bisphosphate aldolase class-I