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Aldoa aldolase, fructose-bisphosphate A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24189, updated on 22-Nov-2020

Summary

Official Symbol
Aldoaprovided by RGD
Official Full Name
aldolase, fructose-bisphosphate Aprovided by RGD
Primary source
RGD:2089
See related
Ensembl:ENSRNOG00000052802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aldo1; RNALDOG5
Summary
member of the aldolase enzyme family [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 41307.8), Heart (RPKM 6179.8) and 2 other tissues See more
Orthologs

Genomic context

See Aldoa in Genome Data Viewer
Location:
1q36
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198228387..198233988, complement)
106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (179057793..179062995, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (205208255..205213627, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene uncharacterized LOC103691235 Neighboring gene TLC domain containing 3B Neighboring gene similar to RIKEN cDNA 4930451I11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
fructose binding ISO
Inferred from Sequence Orthology
more info
 
fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose-bisphosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
 
fructose-bisphosphate aldolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
 
fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose 1,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
fructose metabolic process ISO
Inferred from Sequence Orthology
more info
 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process ISO
Inferred from Sequence Orthology
more info
 
glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
methylglyoxal biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
M band IEA
Inferred from Electronic Annotation
more info
 
Z disc ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
sperm fibrous sheath ISO
Inferred from Sequence Orthology
more info
 
sperm head ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fructose-bisphosphate aldolase A
Names
aldolase A, fructose-bisphosphate
muscle-type aldolase
NP_001170776.1
NP_001258465.1
NP_036627.1
XP_006230272.1
XP_006230273.1
XP_017444263.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177305.1NP_001170776.1  fructose-bisphosphate aldolase A

    See identical proteins and their annotated locations for NP_001170776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    CO383722, CO398643, M14420
    UniProtKB/Swiss-Prot
    P05065
    Related
    ENSRNOP00000069507.1, ENSRNOT00000087928.1
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  2. NM_001271536.1NP_001258465.1  fructose-bisphosphate aldolase A

    See identical proteins and their annotated locations for NP_001258465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AABR07005779, CB750468, CF975930, FQ228954, FQ229100
    UniProtKB/Swiss-Prot
    P05065
    Related
    ENSRNOP00000069540.1, ENSRNOT00000088473.1
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  3. NM_012495.2NP_036627.1  fructose-bisphosphate aldolase A

    See identical proteins and their annotated locations for NP_036627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AABR07005779, BC064440, CO383722
    UniProtKB/Swiss-Prot
    P05065
    Related
    ENSRNOP00000068764.1, ENSRNOT00000080988.1
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    198228387..198233988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230211.2XP_006230273.1  fructose-bisphosphate aldolase A isoform X2

    See identical proteins and their annotated locations for XP_006230273.1

    UniProtKB/Swiss-Prot
    P05065
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  2. XM_006230210.3XP_006230272.1  fructose-bisphosphate aldolase A isoform X1

    See identical proteins and their annotated locations for XP_006230272.1

    Conserved Domains (1) summary
    pfam00274
    Location:69418
    Glycolytic; Fructose-bisphosphate aldolase class-I
  3. XM_017588774.1XP_017444263.1  fructose-bisphosphate aldolase A isoform X1

    Conserved Domains (1) summary
    pfam00274
    Location:69418
    Glycolytic; Fructose-bisphosphate aldolase class-I

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    179057793..179062995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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