Alb albumin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Albprovided by RGD
Official Full Name: albuminprovided by RGD
Primary source: RGD:2085
See related: Ensembl:ENSRNOG00000002911
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Alb1; Albza
Summary: may play a role in nitric oxide signaling; may mediate formation of S-nitrosothiols [RGD, Feb 2006]
Expression: Restricted expression toward (RPKM 349119.2) See more
Orthologs: human mouse all

Genomic context

Location:: 14p22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (19176275..19191793, complement)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	14	NC_005113.3 (19083045..19098563, complement)

Chromosome 14 - NC_005113.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Tubular Expression and Urinary Excretion of MMP-9 Protein Were Increased in Association with Albumin Overload in the Diabetic Kidneys.
Title: Endocytosis of Albumin Induces Matrix Metalloproteinase-9 by Activating the ERK Signaling Pathway in Renal Tubule Epithelial Cells.
albumin immunoreactivity was newly observed in microglia in the hippocampal CA1 region following 5 min of transient cerebral ischemia. These results indicate that transient ischemia-induced albumin expression in microglia might be associated with ischemia-induced 'delayed neuronal death' in the hippocampal CA1 pyramidal neurons.
Title: Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus.
significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn
Title: Mechanism of increased clearance of glycated albumin by proximal tubule cells.
Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3
Title: Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 In Vitro.
Megalin/cubilin and lysosome rupture is involved in albumin-triggered tubular injury and tubulointerstitial inflammation.
Title: Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.
Both insulin and high glucose concentrations enhance the permeability of podocytes to albumin by stimulating oxygen free radical production, primarily by NAD(P)H oxidase-4 (NOX4), and by activating protein kinase G, isoform Ialpha.
Title: Combined effect of insulin and high glucose concentration on albumin permeability in cultured rat podocytes.
Overall, rats with albumin deficiency display enhanced glucose tolerance, insulin secretion and gluconeogenic flux.
Title: Enhanced insulin secretion and glucose tolerance in rats exhibiting low plasma free fatty acid levels and hypertriglyceridaemia due to congenital albumin deficiency.
albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase
Title: Human albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase in in vitro and in vivo.
Data indicate that transcription of Alb is regulated by a complicated system of distant enhancers.
Title: Systematic targeted integration to study Albumin gene control elements.
This pioneering study determined a higher level of ischemia-modified albumin in a testicular torsion model.
Title: Investigation of the possibility of using ischemia-modified albumin in testicular torsion: an experimental study.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Pathways from BioSystems

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Bile acid and bile salt metabolism, organism-specific biosystem (from REACTOME)
Bile acid and bile salt metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
HDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
HDL-mediated lipid transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
Lipid digestion, mobilization, and transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
Lipoprotein metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Recycling of bile acids and salts, organism-specific biosystem (from REACTOME)
Recycling of bile acids and salts, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
SLC-mediated transmembrane transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Scavenging of heme from plasma, organism-specific biosystem (from REACTOME)
Scavenging of heme from plasma, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Thyroid hormone synthesis, organism-specific biosystem (from KEGG)
Thyroid hormone synthesis, organism-specific biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
Thyroid hormone synthesis, conserved biosystem (from KEGG)
Thyroid hormone synthesis, conserved biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport of organic anions, organism-specific biosystem (from REACTOME)
Transport of organic anions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport of vitamins, nucleosides, and related molecules, organism-specific biosystem (from REACTOME)
Transport of vitamins, nucleosides, and related molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Alb1 (e-PCR), detects polymorphism
- UniSTS:141069

D14Wox11 (e-PCR)
- UniSTS:118050

D14Arb4 (e-PCR), detects polymorphism
- UniSTS:226598

D14Wox10 (e-PCR)
- UniSTS:118107

PMC86057P4 (e-PCR)
- UniSTS:273516

UniSTS:465369 (e-PCR)
- UniSTS:465369

Alb (e-PCR), detects polymorphism
- UniSTS:465369

PMC275467P2 (e-PCR)
- UniSTS:272383

Homology

Homologs of the Alb gene: The Alb gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and frog.
Orthologs from Annotation Pipeline: 155 organisms have orthologs with human gene Alb
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
DNA binding	ISO Inferred from Sequence Orthology more info
DNA binding	ISS Inferred from Sequence or Structural Similarity more info
chaperone binding	IEA Inferred from Electronic Annotation more info
chaperone binding	ISO Inferred from Sequence Orthology more info
drug binding	IPI Inferred from Physical Interaction more info	PubMed
drug binding	ISO Inferred from Sequence Orthology more info
drug binding	ISS Inferred from Sequence or Structural Similarity more info
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
fatty acid binding	IEA Inferred from Electronic Annotation more info
fatty acid binding	ISO Inferred from Sequence Orthology more info
fatty acid binding	ISS Inferred from Sequence or Structural Similarity more info
identical protein binding	IEA Inferred from Electronic Annotation more info
identical protein binding	ISO Inferred from Sequence Orthology more info
oxygen binding	IEA Inferred from Electronic Annotation more info
contributes_to oxygen binding	ISO Inferred from Sequence Orthology more info
contributes_to oxygen binding	ISS Inferred from Sequence or Structural Similarity more info
pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
pyridoxal phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
toxic substance binding	IEA Inferred from Electronic Annotation more info
toxic substance binding	ISO Inferred from Sequence Orthology more info
toxic substance binding	ISS Inferred from Sequence or Structural Similarity more info
zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cellular response to starvation	IEA Inferred from Electronic Annotation more info
cellular response to starvation	ISO Inferred from Sequence Orthology more info
cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
hemolysis by symbiont of host erythrocytes	IEA Inferred from Electronic Annotation more info
hemolysis by symbiont of host erythrocytes	ISO Inferred from Sequence Orthology more info
hemolysis by symbiont of host erythrocytes	ISS Inferred from Sequence or Structural Similarity more info
maintenance of mitochondrion location	IEA Inferred from Electronic Annotation more info
maintenance of mitochondrion location	ISO Inferred from Sequence Orthology more info
maintenance of mitochondrion location	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of circadian sleep/wake cycle, non-REM sleep	IDA Inferred from Direct Assay more info	PubMed
response to mercury ion	IEP Inferred from Expression Pattern more info	PubMed
response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
response to platinum ion	IEP Inferred from Expression Pattern more info	PubMed
vasodilation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
Golgi apparatus	ISO Inferred from Sequence Orthology more info
basement membrane	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
extracellular exosome	IEA Inferred from Electronic Annotation more info
extracellular exosome	ISO Inferred from Sequence Orthology more info
extracellular region	ISO Inferred from Sequence Orthology more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
myelin sheath	IEA Inferred from Electronic Annotation more info
myelin sheath	ISO Inferred from Sequence Orthology more info
protein-containing complex	IEA Inferred from Electronic Annotation more info
protein-containing complex	ISO Inferred from Sequence Orthology more info
protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serum albumin

NP_599153.2

EC 6.1.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.