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Alb albumin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24186, updated on 8-Dec-2022

Summary

Official Symbol
Albprovided by RGD
Official Full Name
albuminprovided by RGD
Primary source
RGD:2085
See related
Ensembl:ENSRNOG00000002911 AllianceGenome:RGD:2085
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Alb1; Albza
Summary
Enables several functions, including fatty acid binding activity; modified amino acid binding activity; and zinc ion binding activity. Involved in several processes, including positive regulation of circadian sleep/wake cycle, non-REM sleep; response to mercury ion; and response to platinum ion. Located in basement membrane and extracellular space. Used to study familial hyperlipidemia. Biomarker of Reye syndrome; obstructive jaundice; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; hepatobiliary system cancer (multiple); hyperthyroxinemia; middle cerebral artery infarction; and psoriasis. Orthologous to human ALB (albumin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 349119.2) See more
Orthologs
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Genomic context

See Alb in Genome Data Viewer
Location:
14p22
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17607397..17622814, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (19176275..19191793, complement)

Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene afamin Neighboring gene alpha-fetoprotein Neighboring gene ribosomal protein L8, pseudogene 4 Neighboring gene ankyrin repeat domain 17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables enterobactin binding ISO
Inferred from Sequence Orthology
more info
 
enables enterobactin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables exogenous protein binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables modified amino acid binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to oxygen binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to oxygen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
enables toxic substance binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in maintenance of mitochondrion location ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of mitochondrion location ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to mercury ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to platinum ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retina homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vasodilation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
albumin
Names
serum albumin
NP_599153.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134326.2NP_599153.2  albumin precursor

    See identical proteins and their annotated locations for NP_599153.2

    Status: PROVISIONAL

    Source sequence(s)
    BC085359
    UniProtKB/Swiss-Prot
    P02770
    UniProtKB/TrEMBL
    A0A0G2JSH5
    Related
    ENSRNOP00000003921.2, ENSRNOT00000003921.5
    Conserved Domains (1) summary
    smart00103
    Location:21204
    ALBUMIN; serum albumin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

    Range
    17607397..17622814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)