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Agtr2 angiotensin II receptor, type 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24182, updated on 22-Nov-2020

Summary

Official Symbol
Agtr2provided by RGD
Official Full Name
angiotensin II receptor, type 2provided by RGD
Primary source
RGD:2072
See related
Ensembl:ENSRNOG00000050006
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AT2R; AT2-R; AT<sub>2</sub>R
Summary
receptor for angiotensin II; vasodilator that regulates many actions in vascular smooth muscle cells and during development [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 176.0), Uterus (RPKM 25.3) and 3 other tissues See more
Orthologs

Genomic context

See Agtr2 in Genome Data Viewer
Location:
Xq34
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (119389480..119393845)
106 current Rn_Celera (GCF_000002265.2) X AC_000089.1 (111375374..111376465)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (119534483..119538667)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 W Neighboring gene similar to hormone-regulated proliferation-associated 20 kDa protein Neighboring gene uncharacterized LOC100911253 Neighboring gene similar to poly(rC) binding protein 2 Neighboring gene hypothetical LOC100363413 Neighboring gene similar to RIKEN cDNA 1110007M04

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein alpha-subunit binding TAS
Traceable Author Statement
more info
PubMed 
angiotensin type II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin type II receptor activity ISO
Inferred from Sequence Orthology
more info
 
angiotensin type II receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger ISO
Inferred from Sequence Orthology
more info
 
aldosterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
brain renin-angiotensin system ISO
Inferred from Sequence Orthology
more info
 
cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellar cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
exploration behavior ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
kidney morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
negative regulation of icosanoid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of norepinephrine secretion IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of blood vessel diameter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of blood vessel diameter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric glomerulus development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of renal sodium excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of metanephros size ISO
Inferred from Sequence Orthology
more info
 
regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
renin-angiotensin regulation of aldosterone production IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
type-2 angiotensin II receptor
Names
AT2
angiotensin II type 2 receptor
angiotensin receptor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012494.3NP_036626.1  type-2 angiotensin II receptor

    See identical proteins and their annotated locations for NP_036626.1

    Status: PROVISIONAL

    Source sequence(s)
    U01908
    UniProtKB/Swiss-Prot
    P35351
    UniProtKB/TrEMBL
    B1WBL8
    Conserved Domains (1) summary
    pfam00001
    Location:62318
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    119389480..119393845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257432.3XP_006257494.1  type-2 angiotensin II receptor isoform X1

    See identical proteins and their annotated locations for XP_006257494.1

    UniProtKB/Swiss-Prot
    P35351
    UniProtKB/TrEMBL
    B1WBL8
    Related
    ENSRNOP00000064709.1, ENSRNOT00000074269.1
    Conserved Domains (1) summary
    pfam00001
    Location:62318
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    111375374..111376465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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