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Adrb2 adrenoceptor beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24176, updated on 22-May-2022

Summary

Official Symbol
Adrb2provided by RGD
Official Full Name
adrenoceptor beta 2provided by RGD
Primary source
RGD:2060
See related
AllianceGenome:RGD:2060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including G-protein alpha-subunit binding activity; beta2-adrenergic receptor activity; and signaling receptor binding activity. Involved in several processes, including chemical synaptic transmission; positive regulation of ion transport; and response to steroid hormone. Located in several cellular components, including caveola; neuronal cell body membrane; and sarcolemma. Is active in glutamatergic synapse. Used to study cardiomyopathy (multiple); congestive heart failure; kidney disease (multiple); and lung disease (multiple). Biomarker of several diseases, including acute kidney failure; artery disease (multiple); congestive heart failure; polycystic ovary syndrome; and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Adrb2 in Genome Data Viewer
Location:
18q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55642459..55644501, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57513792..57515834, complement)

Chromosome 18 - NC_051353.1Genomic Context describing neighboring genes Neighboring gene SH3 domain and tetratricopeptide repeats 2 Neighboring gene uncharacterized LOC120098151 Neighboring gene uncharacterized LOC102556293 Neighboring gene uncharacterized LOC108348797 Neighboring gene 5-hydroxytryptamine receptor 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables B2 bradykinin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables PDZ domain binding TAS
Traceable Author Statement
more info
PubMed 
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables beta2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta2-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables epinephrine binding TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables norepinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables norepinephrine binding ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor-receptor interaction IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in associative learning IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within bone resorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway by arrestin ISO
Inferred from Sequence Orthology
more info
 
involved_in diaphragm contraction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within diet induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in estrous cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within heat generation ISO
Inferred from Sequence Orthology
more info
 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP-dependent activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of heart contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mini excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of the force of heart contraction by epinephrine IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by norepinephrine-epinephrine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to catecholamine IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to cold ISO
Inferred from Sequence Orthology
more info
 
involved_in response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to monoamine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-2 adrenergic receptor
Names
Adrenergic beta 2- receptor surface
adrenergic receptor, beta 2
adrenergic, beta-2-, receptor, surface
adrenoceptor beta 2, surface
beta-2 adrenoceptor
beta-2 adrenoreceptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012492.2NP_036624.2  beta-2 adrenergic receptor

    See identical proteins and their annotated locations for NP_036624.2

    Status: VALIDATED

    Source sequence(s)
    BC086538
    UniProtKB/TrEMBL
    Q8VBU7
    Conserved Domains (2) summary
    pfam00001
    Location:50326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48340
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051353.1 Reference mRatBN7.2 Primary Assembly

    Range
    55642459..55644501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)