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Atp8b4 ATPase, class I, type 8B, member 4 [ Mus musculus (house mouse) ]

Gene ID: 241633, updated on 24-Jan-2023

Summary

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Official Symbol
Atp8b4provided by MGI
Official Full Name
ATPase, class I, type 8B, member 4provided by MGI
Primary source
MGI:MGI:1859664
See related
Ensembl:ENSMUSG00000060131 AllianceGenome:MGI:1859664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Im
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane and trans-Golgi network. Orthologous to human ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 2.3), liver E14 (RPKM 2.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Atp8b4 in Genome Data Viewer
Location:
2; 2 F1
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126162893..126342589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126320973..126500669, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227, member B Neighboring gene DTW domain containing 1 Neighboring gene predicted gene, 54149 Neighboring gene Brca1 associated protein 1 pseudogene Neighboring gene predicted gene, 26697 Neighboring gene solute carrier family 27 (fatty acid transporter), member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • MGC161341, A530043E15

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
probable phospholipid-transporting ATPase IM
Names
ATPase 8B4, p type
ATPase B4, class I
NP_001074413.2
NP_001346904.1
XP_006499558.1
XP_006499561.1
XP_006499562.1
XP_006499563.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080944.3 → NP_001074413.2  probable phospholipid-transporting ATPase IM

    See identical proteins and their annotated locations for NP_001074413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK173307, AL929245, BC130260
    Consensus CDS
    CCDS50698.1
    UniProtKB/TrEMBL
    A1L3S5, A2ANX3, Q69Z59
    Related
    ENSMUSP00000047302.7, ENSMUST00000040149.13
    Conserved Domains (1) summary
    cd02073
    Location:31 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  2. NM_001359975.1 → NP_001346904.1  probable phospholipid-transporting ATPase IM

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL831764, AL929245
    Consensus CDS
    CCDS50698.1
    UniProtKB/TrEMBL
    A2ANX3
    Related
    ENSMUSP00000046444.6, ENSMUST00000040128.12
    Conserved Domains (1) summary
    cd02073
    Location:31 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126162893..126342589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499495.1 → XP_006499558.1  probable phospholipid-transporting ATPase IM isoform X1

    See identical proteins and their annotated locations for XP_006499558.1

    UniProtKB/TrEMBL
    A2ANX3
    Conserved Domains (1) summary
    cd02073
    Location:31 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  2. XM_006499500.4 → XP_006499563.1  probable phospholipid-transporting ATPase IM isoform X4

    Conserved Domains (1) summary
    cd02073
    Location:31 → 707
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  3. XM_006499498.5 → XP_006499561.1  probable phospholipid-transporting ATPase IM isoform X2

    Conserved Domains (1) summary
    cd02073
    Location:31 → 707
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  4. XM_006499499.5 → XP_006499562.1  probable phospholipid-transporting ATPase IM isoform X3

    Conserved Domains (1) summary
    cd02073
    Location:31 → 720
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
Nucleotide Protein Strain
Heading Accession and Version

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