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Atp8b4 ATPase, class I, type 8B, member 4 [ Mus musculus (house mouse) ]

Gene ID: 241633, updated on 11-Apr-2024

Summary

Official Symbol
Atp8b4provided by MGI
Official Full Name
ATPase, class I, type 8B, member 4provided by MGI
Primary source
MGI:MGI:1859664
See related
Ensembl:ENSMUSG00000060131 AllianceGenome:MGI:1859664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Im
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane and trans-Golgi network. Orthologous to human ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 2.3), liver E14 (RPKM 2.0) and 10 other tissues See more
Orthologs
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Genomic context

Location:
2 F1; 2 61.76 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126162893..126342589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126320973..126500669, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125977713-125977822 Neighboring gene DTW domain containing 1 Neighboring gene predicted gene, 54149 Neighboring gene STARR-seq mESC enhancer starr_05598 Neighboring gene STARR-seq mESC enhancer starr_05599 Neighboring gene STARR-seq mESC enhancer starr_05600 Neighboring gene STARR-positive B cell enhancer ABC_E2643 Neighboring gene STARR-seq mESC enhancer starr_05601 Neighboring gene STARR-seq mESC enhancer starr_05602 Neighboring gene STARR-seq mESC enhancer starr_05603 Neighboring gene STARR-positive B cell enhancer mm9_chr2:126188755-126189056 Neighboring gene Brca1 associated protein 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:126292531-126292684 Neighboring gene STARR-positive B cell enhancer ABC_E4495 Neighboring gene STARR-seq mESC enhancer starr_05604 Neighboring gene STARR-seq mESC enhancer starr_05605 Neighboring gene STARR-seq mESC enhancer starr_05606 Neighboring gene predicted gene, 26697 Neighboring gene solute carrier family 27 (fatty acid transporter), member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Clone Names

  • MGC161341, A530043E15

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
probable phospholipid-transporting ATPase IM
Names
ATPase 8B4, p type
ATPase B4, class I
NP_001074413.2
NP_001346904.1
XP_006499558.1
XP_006499561.1
XP_006499562.1
XP_006499563.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080944.3NP_001074413.2  probable phospholipid-transporting ATPase IM

    See identical proteins and their annotated locations for NP_001074413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK173307, AL929245, BC130260
    Consensus CDS
    CCDS50698.1
    UniProtKB/TrEMBL
    A2ANX3
    Related
    ENSMUSP00000047302.7, ENSMUST00000040149.13
    Conserved Domains (1) summary
    cd02073
    Location:31975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  2. NM_001359975.1NP_001346904.1  probable phospholipid-transporting ATPase IM

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL831764, AL929245
    Consensus CDS
    CCDS50698.1
    UniProtKB/TrEMBL
    A2ANX3
    Related
    ENSMUSP00000046444.6, ENSMUST00000040128.12
    Conserved Domains (1) summary
    cd02073
    Location:31975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126162893..126342589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499495.1XP_006499558.1  probable phospholipid-transporting ATPase IM isoform X1

    See identical proteins and their annotated locations for XP_006499558.1

    UniProtKB/TrEMBL
    A2ANX3
    Conserved Domains (1) summary
    cd02073
    Location:31975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  2. XM_006499500.4XP_006499563.1  probable phospholipid-transporting ATPase IM isoform X4

    UniProtKB/TrEMBL
    Q69Z59
    Conserved Domains (1) summary
    cd02073
    Location:31707
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  3. XM_006499498.5XP_006499561.1  probable phospholipid-transporting ATPase IM isoform X2

    UniProtKB/TrEMBL
    Q69Z59
    Conserved Domains (1) summary
    cd02073
    Location:31707
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  4. XM_006499499.5XP_006499562.1  probable phospholipid-transporting ATPase IM isoform X3

    UniProtKB/TrEMBL
    Q69Z59
    Conserved Domains (1) summary
    cd02073
    Location:31720
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C