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Acly ATP citrate lyase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24159, updated on 12-Jan-2022

Summary

Official Symbol
Aclyprovided by RGD
Official Full Name
ATP citrate lyaseprovided by RGD
Primary source
RGD:2018
See related
Ensembl:ENSRNOG00000016924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ACL; Clatp
Summary
Enables ATP citrate synthase activity. Involved in acetyl-CoA metabolic process; citrate metabolic process; and fatty acid biosynthetic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Adrenal (RPKM 1293.6), Liver (RPKM 1056.3) and 9 other tissues See more
Orthologs
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Genomic context

See Acly in Genome Data Viewer
Location:
10q31
Exon count:
30
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85412045..85464253, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88392248..88442845, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 10 Neighboring gene kelch-like family member 11 Neighboring gene transfer RNA serine (anticodon AGA) Neighboring gene outer dynein arm docking complex subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124629

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP citrate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP citrate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP citrate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP citrate synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in acetyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in acetyl-CoA biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in acetyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in citrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in citrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in citrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in oxaloacetate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-citrate synthase
Names
ATP-citrate (pro-S-)-lyase
citrate cleavage enzyme
NP_001104565.1
NP_058683.2
XP_038941092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111095.1NP_001104565.1  ATP-citrate synthase isoform 2

    See identical proteins and their annotated locations for NP_001104565.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC100618, CB800173, CR471829, DY473160, J05210
    UniProtKB/Swiss-Prot
    P16638
    UniProtKB/TrEMBL
    G3V9G4
    Related
    ENSRNOP00000046597.3, ENSRNOT00000043172.5
    Conserved Domains (6) summary
    cd06100
    Location:8461083
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1419
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:4791084
    PLN02522; ATP citrate (pro-S)-lyase
    pfam16114
    Location:247421
    Citrate_bind; ATP citrate lyase citrate-binding
    cl21454
    Location:487590
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl22543
    Location:650775
    Ligase_CoA; CoA-ligase
  2. NM_016987.2NP_058683.2  ATP-citrate synthase isoform 1

    See identical proteins and their annotated locations for NP_058683.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BC100618, CB800173, CR471829, DY473160, J05210
    UniProtKB/Swiss-Prot
    P16638
    UniProtKB/TrEMBL
    G3V888
    Related
    ENSRNOP00000023447.3, ENSRNOT00000023447.7
    Conserved Domains (2) summary
    PLN02522
    Location:4891094
    PLN02522; ATP citrate (pro-S)-lyase
    cl29684
    Location:1419
    Citrate_bind; ATP citrate lyase citrate-binding

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    85412045..85464253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085164.1XP_038941092.1  ATP-citrate synthase isoform X1

    Conserved Domains (2) summary
    PLN02522
    Location:4891094
    PLN02522; ATP citrate (pro-S)-lyase
    cl29684
    Location:1419
    Citrate_bind; ATP citrate lyase citrate-binding
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